Large-Scale Multi-Omic Approaches and Atlas-Based Profiling for Cellular, Molecular, and Functional Specificity, Heterogeneity, and Diversity in the Endocannabinoid System
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 15 February 2025 | Viewed by 1565
Special Issue Editors
Interests: large-scale single-cell omics; cluster analysis (UMAP, TSNE, PCA, etc.); imaging mass spectrometry; single-molecule visualization (JA); the endocannabinoid system; development; plasticity; epilepsy; neurotransmission; calcium signaling (MA)
Special Issues, Collections and Topics in MDPI journals
Interests: large-scale single-cell omics; cluster analysis (UMAP, TSNE, PCA, etc.); imaging mass spectrometry; single-molecule visualization (JA); the endocannabinoid system; development; plasticity; epilepsy; neurotransmission; calcium signaling (MA)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The endocannabinoid system includes cannabinoid receptors, endocannabinoids (eCBs), and synthesizing and degrading enzymes. This is a widely recognized lipid messenger system involved in many aspects of our lives including development, learning and memory, and diseases. The identification of the localization and diverse functions of eCBs and cognate receptors has advanced our understanding of how this bioactive lipid system regulates our bodies and minds. Although it is a fundamental step to investigate each element of the eCB system with the cell morphology under defined biological and medical conditions, it is desirable if we could integrate spot-targeted knowledge into an atlas- or repository-type data set, as it can open up new vistas for discovering underexplored molecules and functions in the eCB system in health and diseases.
In this Special Issue, we discuss large-scale multi-omic data generation and data processing with dimensionality reduction, data visualization, and cluster analysis in order to understand molecular lineage and construct multi-layered maps of cell-type-specific markers for ligands, receptors, and related enzymes. Cellular and molecular specificity, heterogeneity, and diversity of each element of the eCB system will be discussed in reference to their functions in a wide range of organisms ranging from cell lines to vertebrates, including humans. We hope a collection of excellent papers found in this Special Issue will contribute to the advancement of lipidomic, proteomic, and transcriptomic investigations of the eCB system and offer an enjoyable forum to develop new ideas in data mining and processing as well as to understand the entire eCB system with fuller perspectives.
Dr. Jun Aoki
Dr. Masako Isokawa
Guest Editors
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Keywords
- lipidomics
- proteomics
- transcriptomics
- cluster analysis
- massive parallel screening
- molecular markers
- brain circuits
- development
- neural plasticity
- synapse
- appetite and feeding behavior
- addiction
- pain
- epilepsy
- neurological disorders
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