Mitochondrial Biology Regulation in Health and Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 802
Special Issue Editors
Interests: cAMP; AMPK; mitochondria; autophagy; heart failure; aging
Special Issues, Collections and Topics in MDPI journals
Interests: apoptosis; autophagy, mitochondria, proteins/lipids interactions in cell death signaling and experimental toxicology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
A mitochondrion is probably the most fascinating organelle contributing besides energy production in almost all aspects of cellular life. Regulation of cellular redox balance and thermogenesis, control of gene expression and metabolic pathways, and contribution to the various cell signaling pathways are just a few ways that mitochondria affect cell life. Hence, mitochondrial homeostasis is a key requirement for cell and organismal health. Dysregulations of mitochondrial dynamics, motility, communication with other organelles, mitogenesis, or mitophagy lead to severe diseases like cancer, neurodegenerative and cardiovascular diseases, diabetes, and inflammation. Numerous extra- and intramitochondrial signaling pathways provide essential transcriptional or post-translational control of mitochondrial function. Interestingly, mitochondria possess several of their own signaling pathways, i.e., separated from cytosolic, regulating post-translational mitochondrial protein modification, e.g., intra-mitochondrial cAMP/cGMP signaling, Sirt3.
This Special Issue aims to bring together a collection of original research and review articles highlighting all aspects of mitochondrial biology regulation, including, among others, OXPHOS activity, ROS formation, apoptosis, mitochondrial life cycle, dynamics, and communication with the nucleus and other organelles.
A special interest of the Issue is the presentation of new mechanisms leading to the disturbance of mitochondrial biology under stress conditions and in diseases.
The Special Issue welcomes high-quality studies applying cell and animal models. Clinical studies, if relevant, as well as computational modeling are also welcome.
Dr. Yury Ladilov
Dr. Patrice X. Petit
Guest Editors
Manuscript Submission Information
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Keywords
- cardiolipin
- mitochondrial biogenesis
- mitochondrial DNA
- mitochondrial dynamics
- mitochondrial gene expression
- mitochondrial signaling
- mitochondrial membrane transporters
- mitochondrial permeability transition
- mitochondrial sirtuins
- mitochondrial cAMP
- TCA
- aging
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