Innovation in Mitochondrial Therapeutics: Pharmaceuticals, Phytochemicals and Nutritional Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: closed (15 February 2019) | Viewed by 517
Special Issue Editor
Interests: bioenergetics; targeting mitochondria in cancer; mitochondrial modulation and medicine; REDOX signaling; metabolic reprogramming
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are launching a Special Issue on mitochondrial drugs given the strong interest in the therapeutic modulation of organelle functions in a large number of human diseases. The pharmaceutical and biotechnology sectors have discovered new compounds able to modulate respiratory chain function and intermediate metabolism with impact on various cell features ranging from migration, differentiation, immune-reactivity or aging. There is a tremendous unmet need for the discovery of medicine acting on the mitochondrion and recent efforts brought new and repurposed molecules to the clinical trial stage. The time has come to give an overview on mitochondrial drug research and to discuss strength and weaknesses, efficacy and toxicity, mechanism of action and resistance, linked with the different approaches. Mitochondrial drugs have implications for the treatment of cancer, rare diseases, metabolic diseases, neurodegenerative disorders and infections so that research at the frontier of these disciplines has emerged in the recent years. In this Special Issue we foster the participation of specialists from both academia and industry to strengthen the translatability of mitochondrial drug discovery.
Dr. Rodrigue Rossignol
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- energy metabolism
- drug
- tool compound
- drug screening
- drug discovery
- drug repurposing
- clinical trial
- preclinical studies
- toxicity
- mode of action
- bioenergetics
- age-related diseases
- rare diseases
- metabolic diseases
- chemoresistance
- Immunology
- oxidative stress
- aging
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