Lysosomal Dysfunction in Neurodegeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 364
Special Issue Editors
Interests: sphingolipids; lysosomes; plasma membrane; neurodegeneration
Interests: sphingolipids; neurodegenerative disorders; GM1 ganglioside; lysosomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With this Special Issue “Lysosomal Dysfunction in Neurodegeneration”, we aim to collect original research and review articles which help to dissect the role of lysosomal impairment in the onset of neurodegeneration.
As all you know, neurodegenerative disorders represent a heterogeneous class of pathologies spread with a growing incidence, especially among the world’s most industrialized areas. Despite the progress in understanding the triggers of neuronal death in almost all neurodegenerative diseases, the precise mechanisms of these pathways are not well established to date and considerable evidence suggests a multifactorial etiology, involving genetic and environmental factors. However, growing evidence implicates the role of lysosomal dysfunction in the onset of neurodegeneration. Indeed, it is known that these organelles are not only involved in degrading and recycling of cellular waste, but are also key players in cellular signaling and energetic metabolism. In particular, the main evidence concerning the importance of these organelles in neuronal functions derives from the study on the neurodegeneration process which occurs in lysosomal storage disorders, a topic that we consider important to be addressed in this Special Issue. In addition, lysosomal impairment and the formation of intracellular inclusions, which have been described in normal brain aging and the pathogenesis of neurodegenerative disorders, such as Parkinson’s disease, frontotemporal dementia, Alzheimer disease, and Huntington disease, is another aspect that will be considered.
Dr. Massimo Aureli
Dr. Giulia Lunghi
Guest Editors
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Keywords
- neurodegenerative diseases
- lysosomes
- lysosomal impairment
- lysosomal storage diseases
- GBA
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