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Children
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Management of Chronic Pain in Adolescents and Children: 2nd Edition
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Management of Chronic Pain in Adolescents and Children: 2nd Edition

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neurology & Neurodevelopmental Disorders".

Deadline for manuscript submissions: 10 July 2025 | Viewed by 3157

Special Issue Editor

Dr. Laura Papetti

E-Mail Website
Guest Editor
Department of Neuroscience, Pediatric Headache Center, Bambino Gesù Children Hospital in Rome, Piazza di Sant’Onofrio 4, 00165 Rome, Italy
Interests: headache; paediatric neurology; migraine; pain
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic pain conditions in paediatric patients include several disorders, such as headache, low back pain, hypermobility, chronic fatigue, abdominal pain, fibromyalgia, and complex regional pain syndrome. The experience of pain is likely to be distressing for both the child and their family when it is not well understood.

The management of diseases associated with chronic pain is often a challenge for clinicians treating children, as many of the pharmacological treatments available in this regard are based on adult data. Moreover, pharmacological treatments are not always applicable and are not effective in all patients. We have little evidence on direct experiences with children. The purpose of this Special Issue is to collect data and direct experiences of doctors and researchers who treat chronic pain in childhood. In particular, attention is given to studies on more recent and innovative pharmacological and non-pharmacological treatments. Contributions on the global management of the patient and their families and on the impact that chronic pain can have on their quality of life are also very important.

Considering the success and popularity of the Special Issue “Management of Chronic Pain in Adolescents and Children” previously published in the journal Children (https://www.mdpi.com/journal/children/special_issues/Management_Chronic_Pain_Adolescents_Children), we are now releasing a Second Issue, aiming to gather original research papers and review articles focused on pain in children.

Dr. Laura Papetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • communication
  • pain
  • pre-operative
  • surgery
  • post-discharge
  • hospitalization
  • procedural pain
  • neurobiology
  • treatment
  • child/children
  • adolescent
  • parents
  • chronic
  • fatigue

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Published Papers (2 papers)

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Research

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12 pages, 282 KiB  
Article
Comorbidities of Rural Children and Adolescents with Migraine and without Migraine
by Suzy Mascaro Walter, Zheng Dai and Kesheng Wang
Children 2023, 10(7), 1133; https://doi.org/10.3390/children10071133 - 29 Jun 2023
Cited by 2 | Viewed by 1474
Abstract
(1) Background: Migraine is associated with comorbidities that are common in the general rural pediatric population. The purpose of this study is to evaluate the differences in the occurrence of comorbidities between rural children and adolescents with and without migraine. (2) Methods: A [...] Read more.
(1) Background: Migraine is associated with comorbidities that are common in the general rural pediatric population. The purpose of this study is to evaluate the differences in the occurrence of comorbidities between rural children and adolescents with and without migraine. (2) Methods: A cross-sectional, secondary data analysis using electronic medical records of 1296 patients (53.8% females, aged 12.4 ± 3.2) was completed. Mann–Whitney U test was used to detect the difference in the number of comorbidities between the two groups. Chi-square test was used to identify the differences in the number of comorbidities, which were classified as low (0–1 comorbidities), medium (2–3 comorbidities), and high (4 or plus comorbidities) degree of comorbidities. (3) Results: Significant differences were found between those children and adolescents with migraine vs. those without for depression (p < 0.0001), anxiety (p < 0.0001), and Ehlers–Danlos Syndrome (EDS; p = 0.0309). A marginally significant difference was found between those children and adolescents with migraine (47.2%; n = 306) vs. those without (42.1%; n = 273) for unhealthy weight (p = 0.0652). Approximately 40% of the migraineurs had 2–3 comorbidities, whereas 32% of the non-migraineurs had 2–3 comorbidities (p = 0.0003). (4) Conclusions: Findings demonstrate the importance of identifying comorbidities associated with rural pediatric migraine in order to develop effective treatment strategies that optimize patient outcomes. Full article
(This article belongs to the Special Issue Management of Chronic Pain in Adolescents and Children: 2nd Edition)

Review

Jump to: Research

14 pages, 344 KiB  
Review
Treatment of Frequent or Chronic Primary Headaches in Children and Adolescents: Focus on Acupuncture
by Ilaria Bonemazzi, Magherita Nosadini, Maria Federica Pelizza, Chiara Paolin, Elena Cavaliere, Stefano Sartori and Irene Toldo
Children 2023, 10(10), 1626; https://doi.org/10.3390/children10101626 - 29 Sep 2023
Viewed by 1287
Abstract
Background: Acupuncture is a spreading and promising intervention, which has proven to be very useful in the treatment and prevention of chronic pain, in particular chronic headaches, in adults; the literature about the treatment of pediatric chronic headaches is scarce. In addition, few [...] Read more.
Background: Acupuncture is a spreading and promising intervention, which has proven to be very useful in the treatment and prevention of chronic pain, in particular chronic headaches, in adults; the literature about the treatment of pediatric chronic headaches is scarce. In addition, few guidelines advise its use in children. The aim of this review is to collect all relevant studies with available data about the use, effect, and tolerability of acupuncture as a treatment for pediatric primary headaches. Methods: This is a narrative review based on eight studies selected from 135 papers including pediatric cases treated with acupuncture for headache. Results: Despite the differences in tools, procedures, and application sites, acupuncture demonstrated a positive effect on both the frequency and intensity of headaches and was well tolerated. There are no studies considering the long-term efficacy of acupuncture. Conclusion: Further additional studies are needed on acupuncture in children and adolescents, with larger series and standardized procedures, in order to better assess efficacy, tolerability, and long-term prognosis and to define guidelines for the use of this promising and safe treatment. It is particularly relevant to identify safe and well-tolerated treatment options in pediatric patients affected by recurrent and debilitating headaches. Full article
(This article belongs to the Special Issue Management of Chronic Pain in Adolescents and Children: 2nd Edition)
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