Long-Term Respiratory Consequences of Prematurity and Early-Life Exposures

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Pulmonary and Sleep Medicine".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 2379

Special Issue Editors


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Guest Editor
Pediatric Respiratory Unit, Department of Pediatrics, University of Patras, 26504 Patras, Greece
Interests: respiratory physiology; lung development; asthma; cariopulmonary exercise testing
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Pediatric Respiratory Unit, Department of Pediatrics, University of Patras, 26504 Patras, Greece
Interests: respiratory physiology; lung development; viral respiratory infections; asthma, smoking

Special Issue Information

Dear Colleagues,

Adverse early-life events may have respiratory consequences that bleed into childhood, adolescence, or even adulthood. Preterm-born children often experience long-term respiratory morbidity, including recurrent wheezing, asthma, lung-function abnormalities, and reduced exercise capacity. Furthermore, early-life exposures, such as perinatal antibiotics, viral infections, nutritional factors, environmental pollutants, and tobacco smoke, can significantly contribute to the development and progression of various respiratory disorders.

This Special Issue aims to highlight the latest discoveries with regards to the Long-Term Respiratory Consequences of Prematurity and Early-Life Exposures. We invite submissions of original research articles, reviews, systematic reviews, meta-analyses, and perspectives exploring various aspects of this field. Potential topics of interest include, but are not limited to, (1) the epidemiology of long-term respiratory morbidity in preterm-born individuals, (2) mechanisms underlying the respiratory morbidity of premature infants in later life, (3) the impact of early-life exposures on respiratory health and disease susceptibility, (4) socioeconomic and other environmental factors that may affect long-term respiratory outcomes in such populations, (5) biomarkers and diagnostic tools for the early detection and monitoring of individuals at risk, and (6) possible interventions to improve the long-term respiratory outcomes of preterm-born infants.

Dr. Sotirios Fouzas
Prof. Dr. Michael Anthracopoulos
Guest Editors

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Keywords

  • prematurity
  • bronchopulmonary dysplasia
  • wheezing
  • asthma
  • exercise capacity
  • respiratory morbidity
  • viral infections
  • lung function
  • environmental exposures
  • tobacco smoke

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Published Papers (1 paper)

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Research

10 pages, 444 KiB  
Article
Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing
by Gavriela Feketea, Emilia Vassilopoulou, Oana Andreescu, Elena Camelia Berghea, Raluca Maria Pop, Octavia Sabin, Mihnea Zdrenghea and Ioana Corina Bocsan
Children 2024, 11(2), 219; https://doi.org/10.3390/children11020219 - 8 Feb 2024
Cited by 1 | Viewed by 2033
Abstract
Introduction and aim: A direct causal relationship between vitamin D (vit D) deficiency and recurrent wheezing has not been proven. The present study investigated the role of vit D in enhancing the risk of asthma or recurrent wheezing by modifying the intensity of [...] Read more.
Introduction and aim: A direct causal relationship between vitamin D (vit D) deficiency and recurrent wheezing has not been proven. The present study investigated the role of vit D in enhancing the risk of asthma or recurrent wheezing by modifying the intensity of the inflammatory process. Material and method: Forty children with wheezing presenting at the emergency service and sixteen healthy control subjects were included in the study. Children with wheezing were either in the first episode (20) or with recurrent wheezing (20). Children with chronic diseases, and other conditions that present with acute wheezing or that might influence the vit D level, were excluded. Blood samples were taken at presentation and 3–6 months later, to evaluate the serum levels of total IgE, vit D, IL-10 and IL-31. Statistical analysis was performed using the SPSS 25 program, with a significance level of p < 0.05. Results and conclusion. The vit D level was lower in patients with recurrent wheezing compared with those with a single episode and with the control group, and this increased with time. IL-10 was significantly higher in children with wheezing than in the control group, with the highest values in those with an acute episode of wheezing. IL-31 was higher in children with recurrent wheezing than in those with a first episode only at the initial point, while at the final time point it was lower. Low levels of vit D appear to be detected more frequently in recurrent wheezing than in simple wheezing. Immune modulation, as measured by Th2 status reflected by IL-10 and IL-31 levels, appears to depend on the wheezing phenotype and on the general health status. Full article
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