Molecular Mechanisms in Multiple Sclerosis
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 750
Special Issue Editor
2. Laboratory of Histology and Embryology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: neuroscience; multiple sclerosis; experimental autoimmune encephalomyelitis; intrathecal transplantation; stem cell differentiation; immunohistopathology; in situ hybridization; electron microscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Multiple sclerosis (MS) is an inflammation-based, chronic demyelinating disease of the central nervous system (CNS), with myelin degeneration and axonopathy being the major neuropathological hallmarks. Since the etiology of MS is still unknown and symptoms exhibit high heterogeneity among the individuals diagnosed, there exists a need to establish new biomarkers and to prioritize the development of research in animal models of MS, particularly at the molecular level.
Despite their limitations, CD4+-driven experimental autoimmune encephalomyelitis (EAE), Theiler׳s murine encephalomyelitis virus (TMEV) infection, and chemically induced demyelination (cuprizone, lysolecithin), individually reflect immunological pathogenesis, axonal impairment, and remyelination processes in MS. Furthermore, EAE can be outstandingly insightful in molecular research of potential experimental treatments, alongside immunogenetics and histopathology.
I hereby invite authors to submit original research or review articles on the molecular mechanisms underlying the pathogenesis of MS or its experimental models in the context of this Special Issue, entitled “Molecular research in multiple sclerosis”. Every submission will undergo meticulous, delay-free scrutiny, in accordance with the standards of the journal.
Dr. Paschalis Theotokis
Guest Editor
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Keywords
- multiple sclerosis
- inflammatory demyelination
- molecular mechanisms
- oligodendrocyte apoptosis
- neurite outgrowth inhibition
- immune regulation
- microglia and macrophages
- experimental autoimmune encephalomyelitis
- therapeutic intervention
- remyelination
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