Circadian Rhythm Disorders in the Era of Circadian Medicine

Dear Colleagues,

Disorders of circadian rhythms, which result from a misalignment between an individual's internal clock and the required timing of daily activities, have traditionally been considered to primarily impact sleep, for example, in shift work or jet lag disorder. There is now strong evidence, however, showing that the alteration of a proper circadian organization (circadian health) either between the internal clocks and external time cues, or between multiple internal clocks, is involved in the pathophysiological models of a variety of conditions beyond classical sleep–wake disorders, including cardiometabolic conditions (diabetes, hypertension, obesity, cardiovascular disease), breast and prostate cancer, neurodegenerative disorders (Alzheimer's and Parkinson's diseases), and depression and mood disorders. When considering the current global health emergency caused by the ongoing pandemic, circadian science has shown that circadian mechanisms are implicated in the complex interaction between host and virus and in influenza-related lung inflammation, and that circadian disruption is associated with dysregulation of inflammatory and immune responses. Therefore, circadian health is rapidly establishing itself as a key factor for the success of preventive and treatment strategies in future personalized circadian medicine. Topics of this issue include but are not limited to the following:

• Pathophysiological mechanisms of circadian rhythm disorders (CRDs);
• Clinical management of CRDs, from diagnosis to treatment;
• Impact of CRDs on public health and society.

Dr. Corrado Garbazza, MD
Guest Editor

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• chronobiology
• circadian rhythm disorders
• chronotherapy
• light
• melatonin
• circadian medicine
• sleep medicine
• sleep–wake rhythm disorders