Plasma Polymerized Films for Biological Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Plasma Coatings, Surfaces & Interfaces".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3087

Special Issue Editors


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Guest Editor
1. Research Institute of Clinical and Experimental Lymphology—Branch of the ICG SB RAS, 2 Timakova St., 630060 Novosibirsk, Russia
2. Aramco Innovations LLC, Moscow, Russia
Interests: plasma chemistry; surface characterization; thin films; nanomaterials; bio-application of plasma polymers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Research Institute of Clinical and Experimental Lymphology, 630060 Novosibirsk, Russia
Interests: cell biology; biochemistry; cancer; bio-nano-materials; platelet-rich plasma; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plasma deposition of thin polymer films is a growing field in which the bio-applications of these films are promising and useful implementations of such materials. The advantages of plasma-deposited polymer layers compared with conventional coatings are numerous: the technology is substrate independent, the environmentally friendly process is low temperature, and such polymer films are versatile. Although the use of plasma technologies for biological applications began more than 30 years ago, there are still many open questions related to the optimization of the process itself, surface chemistry, real application of these films for tissue engineering, etc. Today, plasma-deposited polymers have been successfully employed for the enhancement of cell adhesion, immobilization of biomolecules, modification of nanomaterials for drug loading, and many other applications. However, all such achievements have only been shown on a laboratory scale, and new scientific input is required in order to push plasma polymerized polymer films toward a higher level of technological readiness.

The aim of this Special Issue of Coatings is to highlight the progress made with respect to plasma polymerized films for biological applications, new bio-applications of plasma layers, new methods for plasma polymerized film characterization, and the development of the fundamental understanding of the interaction between the surface of plasma polymers with biomolecules and cells.

In particular, topics of interest include, but are not limited to, the following:

  • in vitro and in vivo analysis of plasma-coated polymers, nanomaterials, and metals;
  • Plasma polymerized films for biosensing;
  • Investigation of the influence of different surface chemistries on cell surface interaction;
  • Deposition of plasma polymers with pH-responsive properties;
  • Antimicrobial plasma polymerized films;
  • Plasma layers for tissue engineering and wound healing.

Dr. Anton M. Manakhov
Dr. Anastasiya Solovieva
Guest Editors

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Published Papers (1 paper)

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16 pages, 3954 KiB  
Article
Plasma-Assisted Deposition of Magnesium-Containing Coatings on Porous Scaffolds for Bone Tissue Engineering
by Vincenza Armenise, Roberto Gristina, Pietro Favia, Savino Cosmai, Francesco Fracassi and Eloisa Sardella
Coatings 2020, 10(4), 356; https://doi.org/10.3390/coatings10040356 - 5 Apr 2020
Cited by 11 | Viewed by 2604
Abstract
Magnesium plays a pivotal role in the formation, growth, and repair of bone tissue; therefore, magnesium-based materials can be considered promising candidates for bone tissue engineering. This study aims to functionalize the surfaces of three-dimensional (3D) porous poly-ε caprolactone (PCL) scaffolds with magnesium-containing [...] Read more.
Magnesium plays a pivotal role in the formation, growth, and repair of bone tissue; therefore, magnesium-based materials can be considered promising candidates for bone tissue engineering. This study aims to functionalize the surfaces of three-dimensional (3D) porous poly-ε caprolactone (PCL) scaffolds with magnesium-containing coatings using cold plasma-assisted deposition processes. For this purpose, the radiofrequency (RF) sputtering of a magnesium oxide target was carried out in a low-pressure plasma reactor using argon, water vapor, hydrogen, or mixtures of argon with one of the latter two options as the feed. Plasma processes produced significant differences in the chemical composition and wettability of the treated PCL samples, which are tightly related to the gas feed composition, as shown by X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA) analyses. Cytocompatibility assays performed with Saos-2 osteoblast cells showed that deposited magnesium-containing thin films favor cell proliferation and adhesion on 3D scaffold surfaces, as well as cell colonization inside them. These films appear to be very promising for bone tissue regeneration. Full article
(This article belongs to the Special Issue Plasma Polymerized Films for Biological Applications)
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