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Functional Surfaces for Biomedical Applications
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Functional Surfaces for Biomedical Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: closed (25 July 2021) | Viewed by 27189

Special Issue Editors

Dr. Shigeng Song

E-Mail Website1 Website2
Guest Editor
Institute of Thin Films, Sensors & Imaging, School of Engineering and Computing, University of the West of Scotland, Paisley PA1 2BE, UK
Interests: deposition process; device simulation and modelling; optical interference filters; photovoltaics; SERS based on sculptured nano thin films; flexible electronics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Waqar Ahmed

E-Mail Website
Guest Editor
School of Mathematics and Physics, University of Lincoln, Lincoln LN6 7TS, UK
Interests: nanomedicine and thin film coatings
Prof. Dr. Desmond Gibson

E-Mail Website1 Website2
Guest Editor
School of Computing, Engineering and Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK
Interests: optical thin film and coatings, including medical device applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is currently a growing need to implant medical devices into the human body for achieving improved healthcare conditions. The areas of application include artificial heart valves, catheters, stents, guidewires, hip joints, intraocular lens, dental implants, biosensors, etc. Most of the current biomaterial implants are not completely biocompatible, haemocompatible, or non-cytotoxic. Many potential implant materials have to be investigated for cellular, protein, and human DNA interactions. The implants can trigger a number of inflammatory responses, thrombogenic reactions, and life-threatening coating failures. This situation has led to the need to apply hemocompatible and biocompatible coatings to improve the performance of biomedical implant materials. This Special Issue of Coatings is now inviting authors to contribute articles and topical reviews reporting on recent leading edge research findings of coatings for medical and biochemical applications in areas that include, but are not necessarily limited to, the topics listed below:

  • Materials and technologies for preparing coatings for medical implants, antimicrobial coatings, coatings for medical textiles and other related applications.
  • Recent progress in overcoming the major challenges in the use of coatings for implantable medical devices: Cellular and blood interactions.
  • Recent progress in managing toxicity issues that arise when coatings are used in medical implants and related applications.
  • The performance of implant coatings in orthopedic applications, such as in coatings for hip, knee and joint implants subjected to friction and wear.
  • The development of coatings for use in protecting medical devices from corrosion, degradation or ion release when used in applications that include minimally-invasive keyhole surgery and other medical applications.
  • Coatings for dental applications.
  • Coatings for surface functionalized drug eluting stents.
  • Coatings for medical sensing applications.

Prof. Dr. Shigeng Song
Prof. Dr. Waqar Ahmed
Prof. Dr. Des Gibson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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20 pages, 5030 KiB  
Article
Physicochemical and Mechanical Properties of Blow Spun Nanofibrous Prostheses Modified with Acrylic Acid and REDV Peptide
by Beata A. Butruk-Raszeja, Aleksandra Kuźmińska, Michał Wojasiński and Zuzanna Piotrowska
Coatings 2020, 10(11), 1110; https://doi.org/10.3390/coatings10111110 - 19 Nov 2020
Cited by 5 | Viewed by 2826
Abstract
The paper presents a method of modifying the inner surface of nanofibrous vascular prostheses. The modification process involves two steps: introducing a hydrophilic linker, followed by a peptide containing the arginine-glutamic acid-aspartic acid-valine (REDV) sequence. The influence of the process parameters (reaction time, [...] Read more.
The paper presents a method of modifying the inner surface of nanofibrous vascular prostheses. The modification process involves two steps: introducing a hydrophilic linker, followed by a peptide containing the arginine-glutamic acid-aspartic acid-valine (REDV) sequence. The influence of the process parameters (reaction time, temperature, initiator concentration) on morphology and the distribution of fiber diameters were examined. For selected optimal parameters, the prostheses were modified in the flow system. Modifications along the entire length of the prosthesis were confirmed—the inlet and the outlet areas showed no significant (p > 0.05) differences in the value of the contact angle and the analyzed morphological parameters. The basic physicochemical and mechanical properties of modified prostheses were analyzed. The study showed that REDV-modified prosthesis has an average fiber diameter of 318 ± 99 nm, the average pore size of 3.0 ± 1.6 μm, the porosity of 48.4 ± 8.6% and Young’s modulus of 4.0 ± 0.4 MPa. The internal diameter of prostheses remains unchained and amounts to 3 mm. Such modified prostheses can reduce the risk of blood coagulation by increasing the surface’s wettability and, most of all, by introducing endothelial cell-selective peptide. As an effect, the proposed surfaces could recruit endothelial progenitor cells directly from the bloodstream and promote the endothelium formation after implantation. Full article
(This article belongs to the Special Issue Functional Surfaces for Biomedical Applications)
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15 pages, 3832 KiB  
Article
Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold
by Ju Xue, Ashley Farris, Yunfei Wang, Weiyan Yeh, Cristina Romany, James K. Guest, Warren L. Grayson, Anthony S. Hall and Timothy P. Weihs
Coatings 2020, 10(8), 715; https://doi.org/10.3390/coatings10080715 - 23 Jul 2020
Cited by 14 | Viewed by 4346
Abstract
In this study, we demonstrate that a uniform coating of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) can be electrochemically deposited onto metallic 3D-woven bone scaffolds to enhance their bioactivity. The HAp coatings were deposited onto metallic scaffolds using [...] Read more.
In this study, we demonstrate that a uniform coating of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) can be electrochemically deposited onto metallic 3D-woven bone scaffolds to enhance their bioactivity. The HAp coatings were deposited onto metallic scaffolds using an electrolyte containing Ca(NO3)2·4H2O, NH4H2PO4, and NaNO3. The deposition potential was varied to maximize the uniformity and adhesion of the coating. Using X-ray diffraction (XRD), Raman spectroscopy, and energy-dispersive spectroscopy (EDS), we found crystallized HAp on the 3D-woven lattice under all deposition potentials, while the −1.5 V mercury sulfate reference electrode potential provided the best local uniformity with a satisfactory deposition rate. The coatings generated under this optimized condition were approximately 5 µm thick and uniform throughout the internal and external sections of the woven lattice. We seeded and cultured both coated and uncoated scaffolds with human adipose-derived stromal/stem cells (ASCs) for 12 h and 4 days. We observed that the HAp coating increased the initial cell seeding efficiency by approximately 20%. Furthermore, after 4 days of culture, ASCs cultured on HAp-coated stainless-steel scaffolds increased by 32% compared to only 17% on the uncoated scaffold. Together, these results suggest that the HAp coating improves cellular adhesion. Full article
(This article belongs to the Special Issue Functional Surfaces for Biomedical Applications)
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23 pages, 7526 KiB  
Article
Influence of Material Composition on Structure, Surface Properties and Biological Activity of Nanocrystalline Coatings Based on Cu and Ti
by Damian Wojcieszak, Malgorzata Osekowska, Danuta Kaczmarek, Bogumila Szponar, Michal Mazur, Piotr Mazur and Agata Obstarczyk
Coatings 2020, 10(4), 343; https://doi.org/10.3390/coatings10040343 - 2 Apr 2020
Cited by 7 | Viewed by 3596
Abstract
In this paper, the influence of material composition on structure and surface properties of bioactive coatings based on Cu and Ti is described. Nanocrystalline coatings were prepared by innovative pulsed DC magnetron sputtering. For their preparation, a multi-magnetron system was used in order [...] Read more.
In this paper, the influence of material composition on structure and surface properties of bioactive coatings based on Cu and Ti is described. Nanocrystalline coatings were prepared by innovative pulsed DC magnetron sputtering. For their preparation, a multi-magnetron system was used in order to obtain films with various copper content. The main goal of our work was the complex analysis of biological activity of Cu-Ti films in comparison with their material composition and surface state. Antimicrobial activity (for E. coli and S. aureus), as well as the impact on cell viability (L929 line), were investigated. The physicochemical properties were examined with the aid of X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic absorption spectroscopy. It was found that all prepared films were nanocrystalline and bactericidal, but their cytotoxicity was related to the Cu-content in the film. Complex analysis of the bioactivity was developed in relation to the copper ion migration process. Moreover, manufacturing of antibacterial films with stimulating action on L929 cell line was possible. Full article
(This article belongs to the Special Issue Functional Surfaces for Biomedical Applications)
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Review

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19 pages, 1391 KiB  
Review
Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization
by Laurine Martocq and Timothy E. L. Douglas
Coatings 2021, 11(8), 983; https://doi.org/10.3390/coatings11080983 - 18 Aug 2021
Cited by 16 | Viewed by 4352
Abstract
Biomaterial surface modification represents an important approach to obtain a better integration of the material in surrounding tissues. Different techniques are focused on improving cell support as well as avoiding efficiently the development of infections, such as by modifying the biomaterial surface with [...] Read more.
Biomaterial surface modification represents an important approach to obtain a better integration of the material in surrounding tissues. Different techniques are focused on improving cell support as well as avoiding efficiently the development of infections, such as by modifying the biomaterial surface with amine groups (–NH2). Previous studies showed that –NH2 groups could promote cell adhesion and proliferation. Moreover, these chemical functionalities may be used to facilitate the attachment of molecules such as proteins or to endow antimicrobial properties. This mini-review gives an overview of different techniques which have been used to obtain amine-rich coatings such as plasma methods and adsorption of biomolecules. In fact, different plasma treatment methods are commonly used with ammonia gas or by polymerization of precursors such as allylamine, as well as coatings of proteins (for example, collagen) or polymers containing –NH2 groups (for example, polyethyleneimine). Moreover, this mini-review will present the methods used to characterize such coatings and, in particular, quantify the –NH2 groups present on the surface by using dyes or chemical derivatization methods. Full article
(This article belongs to the Special Issue Functional Surfaces for Biomedical Applications)
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23 pages, 13673 KiB  
Review
Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications
by Wei Liu, Shifeng Liu and Liqiang Wang
Coatings 2019, 9(4), 249; https://doi.org/10.3390/coatings9040249 - 15 Apr 2019
Cited by 126 | Viewed by 10982
Abstract
With the increasing demand for bone implant therapy, titanium alloy has been widely used in the biomedical field. However, various potential applications of titanium alloy implants are easily hampered by their biological inertia. In fact, the interaction of the implant with tissue is [...] Read more.
With the increasing demand for bone implant therapy, titanium alloy has been widely used in the biomedical field. However, various potential applications of titanium alloy implants are easily hampered by their biological inertia. In fact, the interaction of the implant with tissue is critical to the success of the implant. Thus, the implant surface is modified before implantation frequently, which can not only improve the mechanical properties of the implant, but also polish up bioactivity and osseoconductivity on a cellular level. This paper aims at reviewing titanium surface modification techniques for biomedical applications. Additionally, several other significant aspects are described in detail in this article, for example, micromorphology, microstructure evolution that determines mechanical properties, as well as a number of issues concerning about practical application of biomedical implants. Full article
(This article belongs to the Special Issue Functional Surfaces for Biomedical Applications)
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