Advances in Functional Cocrystals
A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Crystal Engineering".
Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 6966
Special Issue Editors
Interests: crystal engineering; supramolecular chemistry; crystallisation; X-ray diffraction; pharmaceutical technology; cocrystals; polymorphs; hydrates; salts; amorphous materials; pre-formulation; physicochemical stability; drug formulation
Interests: pharmaceuticals; encapsulation; structure-property relationships; crystal engineering; polymorphism; drug formulations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The field of cocrystals is rapidly growing in solid-state science, comprising crystal engineers, pharmaceutical researchers, chemists, chemical engineers, computational researchers from academia and industry. Cocrystals, being the multicomponent solids incorporating two or more solids in a crystal lattice, show great promise in modulating physicochemical properties of the constituents. Last few decades have witnessed an enormous advancement in the design and synthesis of cocrystals which paved the way for novel drug products and improved functional materials.
The current special issue makes an attempt to showcase recent developments in the functional cocrystals and current research interests within the broad theme of cocrystals. The focus of the issue covers, but not limited to, control of physicochemical attributes henceforth bioavailability, stability and manufacturability of active pharmaceutical ingredient into solid dosage form via pharmaceutical cocrystals, polymorphism in cocrystals, behaviour of cocrystals in solution media, cocrystal formulations and scale up of cocrystals from laboratory to large-scale production. Recent studies show that, beside pharmaceuticals, cocrystallization can also be used to modify the properties of nutraceuticals, agrochemicals and specialty chemicals, explosives, and optical properties of materials such as thermochromism, modulated fluorescence and photolithography. Tailored modulation of magnetic and electronic properties of materials by cocrystallization is an emerging area of research in the recent times. In addition to experimental approaches with cocrystals, there has been considerable success with rational design and computational prediction of cocrystals supported by over million crystal structures and statistical information that can be retrieved from Cambridge Structural Database.
The current Special Issue on “Advances in Functional Cocrystals” serves as an excellent international platform to report results that highlight design and synthesis of cocrystals and their potential applications in wide-range of research fields. We invite contributions from scientists working in all disciplines related to the development of cocrystals. We hope that readers will find this issue both interesting and stimulating.
Dr. Venu Vangala
Dr. Srinivasulu Aitipamula
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- crystal engineering and supramolecular chemistry
- cocrystals, pharmaceutical cocrystals, functional cocrystals
- supramolecular synthesis, homo and heterosynthons
- salts, polymorphs, hydrates, solvates, eutectics, coamorphous compounds
- pharmaceuticals/ drug development/ solid dosage form
- nutraceuticals/agrochemicals/optical/ magnetic/explosive materials
- x-ray diffraction (single crystal x-ray diffraction, powder x-ray diffraction)
- thermal, spectroscopy and advanced analytical characterizations
- structure-property relationships
- physicochemical properties, micromeritics, biopharmaceutical properties
- solubility, dissolution rate
- permeability, pharmacokinetic and pharmacodynamic properties
- physical stability, hygroscopicity, chemical stability and photostability
- mechanical properties, tabletability, compressibility
- mechanical grinding, neat and liquid assisted grinding
- solution and solvent-free crystallizations
- cambridge structural database
- crystal structure prediction
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