Polymorphism in Pharmaceutical Compounds

A special issue of Crystals (ISSN 2073-4352).

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4583

Special Issue Editor


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Guest Editor
Department of Chemistry, Ben-Gurion University of the Negev, Be'er Sheva, Israel
Interests: polymorphs; crystalliation; morphology engineering; organic biological optically functional crystals

Special Issue Information

Dear Colleagues,

Polymorphism is the ability of solids to be able to exist in two or more crystalline forms with different arrangements in the crystal lattice. Polymorphic forms of a drug differ in the physicochemical properties such as dissolution and solubility, chemical and physical stability, flowability and hygroscopicity and, hence, differ in various important drug outcomes, such as drug efficacy, bioavailability, and even toxicity. Polymorphic studies are important as a particular polymorph can be responsible for a particular property which might not be exhibited by any other form. In this Special Issue, we would like to invite the authors who can write their results, or review in the direction research scope such as polymorphism, applications in pharmaceuticals drugs and challenges, manufacturing of drugs. Hence we like to have researchers contribution in this scope.

Dr. Geetha Bolla
Guest Editor

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Keywords

  • Polymorphs
  • pharma drugs
  • crystallization
  • physicochemical property

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Published Papers (1 paper)

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Review

13 pages, 2404 KiB  
Review
Structural Characterization of Pharmaceutical Cocrystals with the Use of Laboratory X-ray Powder Diffraction Patterns
by Vladimir V. Chernyshev
Crystals 2023, 13(4), 640; https://doi.org/10.3390/cryst13040640 - 9 Apr 2023
Cited by 4 | Viewed by 3230
Abstract
X-ray powder diffraction is a vital analytical tool that is used in pharmaceutical science. It is increasingly used to establish the crystal structure of a new pharmaceutical substance, in particular, cocrystal or its polymorphic forms. This review begins with a brief discussion of [...] Read more.
X-ray powder diffraction is a vital analytical tool that is used in pharmaceutical science. It is increasingly used to establish the crystal structure of a new pharmaceutical substance, in particular, cocrystal or its polymorphic forms. This review begins with a brief discussion of the reliability of the structural parameters retrieved from powder patterns. Recent examples of the successful determination of crystal structures of pharmaceutical cocrystals and salts from powder diffraction data are discussed. These examples show the increased capabilities of laboratory X-ray powder diffractometers and modern software in solving actual problems of pharmaceutical science. Full article
(This article belongs to the Special Issue Polymorphism in Pharmaceutical Compounds)
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