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Brain Health
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Brain Health

A special issue of Clinical and Translational Neuroscience (ISSN 2514-183X).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 8134

Special Issue Editors

Prof. Dr. Claudio Bassetti

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Guest Editor
Department of Neurology, Inselspital University Hospital of Bern, Bern, Switzerland
Interests: general neurology; sleep-wake medicine; coma/disorders of consciousness; stroke medicine; Parkinson's movement disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Lukas Sveikata

E-Mail Website
Co-Guest Editor
Department of Neurology, University Hospital of Geneva and University of Geneva, Geneva, Switzerland
Interests: cerebral small vessel diseases; cerebral amyloid angiopathy; vascular cognitive impairment and dementia; Alzheimer’s disease
Prof. Dr. Susanne Wegener

E-Mail Website
Co-Guest Editor
Department of Neurology, University of Zurich, Zurich, Switzerland
Interests: MRI data of deep neural networks in acute stroke
Prof. Dr. Indrit Bègue

E-Mail Website
Co-Guest Editor
Department of Psychiatry, Université de Genève, Geneva, Switzerland
Interests: apathy; cognitive deficits; schizophrenia; transcranial magnetic stimulation; translational psychiatry

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a Special Issue entitled “Brain Health” in the MDPI journal Clinical and Translational Neuroscience.

Our brain plays a crucial role in all aspects of our lives; it is essential for cognitive, motor, and sensory functions, as well as our experiences, emotions, and behavior. In addition, it influences vascular, endocrine, and immunological processes in our body. Ultimately, the brain and its health are essential for our individual (physical, mental, social, and spiritual) wellbeing, for unlocking our potential (in terms of knowledge, skills, and creativity) as individuals, and for the sustainable development of a fair, well-functioning, and productive society.

According to the World Health Organization (WHO) and recent peer-reviewed publications, more than one in three people is affected by a neurological disorder (ND), and at least one in three is affected by a mental (psychiatric) disorder (MD). Brain disorders surpass cardiovascular disorders and cancer combined in terms of disability, mortality, and costs.

The “Brain Health” Special Issue is dedicated to not only advancing basic and translational knowledge, but also to fostering international collaborations and initiatives to promote brain health and science-based prevention of brain disorders throughout the life course for all people worldwide.

We eagerly await your submissions to contribute to this crucial conversation about brain health.

Warm regards,

Prof. Dr. Claudio Bassetti
Dr. Lukas Sveikata
Prof. Dr. Susanne Wegener
Prof. Dr. Indrit Bègue
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical and Translational Neuroscience is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain health
  • cognitive functions
  • physical, mental, social, and spiritual wellbeing motor and sensory functions
  • neurological disorder
  • mental (psychiatric) disorder

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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9 pages, 206 KiB  
Review
Brain Health in Neuroradiology
by Karl-Olof Lövblad, Isabel Wanke, Daniele Botta, Felix T. Kurz, Roland Wiest, Daniel Rüfenacht and Luca Remonda
Clin. Transl. Neurosci. 2025, 9(1), 1; https://doi.org/10.3390/ctn9010001 - 31 Dec 2024
Viewed by 680
Abstract
Neuroradiology, as a modern branch of the neurosciences and radiological sciences, has an impact on global health, particularly on brain health. On the one hand, neuroradiology directly impacts diseases of the nervous system, such as stroke and inflammatory diseases, by providing an all-in-one [...] Read more.
Neuroradiology, as a modern branch of the neurosciences and radiological sciences, has an impact on global health, particularly on brain health. On the one hand, neuroradiology directly impacts diseases of the nervous system, such as stroke and inflammatory diseases, by providing an all-in-one package combining imaging, diagnosis, treatment, and follow-up. This has been impacted by the continuous evolution over the last decades of both diagnostic and interventional tools in parallel: this was the case in stroke, where the endovascular treatment was followed closely by developments in fast MRI techniques and multi-slice CT imaging. Additionally, inflammatory diseases of the brain, as well as tumors of the central nervous system, can be imaged and localized in order to set in place both an early diagnosis and initiate treatment. Neurodegenerative diseases such as Alzheimer’s disease, in which treatment options are appearing on the horizon, also benefit from the use of modern neuroimaging techniques. On the other hand, neuroradiology plays an important role in the prevention and prediction of brain diseases and helps in building up the so-called digital twin, often from birth till late in life. Additionally, the practice of neuroradiology itself is evolving to not only improve patient health but also the health of the practitioners of neuroradiology themselves. By improving the overall work environment also, neuroradiologists will be working under better conditions and will suffer less fatigue and burn-out, thereby providing better service to patients and population. By using less radiation for diagnostic tests and shifting to techniques that rely more and more on either magnetic resonance or ultra-sound techniques, the radiation load on the population and on the neuroradiologists will decrease. Furthermore, using less contrast, such as gadolinium, has been shown to result in fewer deposits in the brains of patients, as well as less pollution at the ocean level, thus contributing to general well-being. Additionally, the implementation and use of artificial intelligence at many levels of the diagnostic and treatment chain will be beneficial to patients and physicians. In this paper, we discuss the place and potential not just of the techniques but of neuroradiology and the neuroradiologist as promoters of brain health and thus global health. Full article
(This article belongs to the Special Issue Brain Health)
15 pages, 1374 KiB  
Review
Sleep Health
by Albrecht P. A. Vorster, Eus J. W. van Someren, Allan I. Pack, Reto Huber, Markus H. Schmidt and Claudio L. A. Bassetti
Clin. Transl. Neurosci. 2024, 8(1), 8; https://doi.org/10.3390/ctn8010008 - 24 Jan 2024
Cited by 2 | Viewed by 4791
Abstract
Together with (physical and mental) exercise, diet, and social activities, sleep is a key health behavior that occupies one third of our lives, yet remains neglected. In the first part of this review, we present the current knowledge on how sleep promotes body, [...] Read more.
Together with (physical and mental) exercise, diet, and social activities, sleep is a key health behavior that occupies one third of our lives, yet remains neglected. In the first part of this review, we present the current knowledge on how sleep promotes body, brain, mental, occupational, and social health as well as creativity, productivity, and well-being. In the second part, we discuss how good sleep and screening for sleep–wake disorders may improve health and reduce the burden of brain, mental, cardiovascular, metabolic disorders and cancer. We also review the literature on measurements of sleep health and present the Bernese Sleep Health Questionnaire, a new and simple tool to assess sleep health and screen for sleep–wake circadian disorders in clinical practice. Full article
(This article belongs to the Special Issue Brain Health)
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10 pages, 666 KiB  
Systematic Review
Long-Term Return to Work After Mild and Moderate Traumatic Brain Injury: A Systematic Literature Review
by Emilia Westarp, Tim Jonas Hallenberger, Karl-Olof Lövblad, Thomas Mokrusch, Claudio Bassetti and Raphael Guzman
Clin. Transl. Neurosci. 2024, 8(4), 31; https://doi.org/10.3390/ctn8040031 - 20 Dec 2024
Viewed by 540
Abstract
Background: Traumatic brain injury (TBI) is referred to as a “silent epidemic” due to its limited awareness in the general public. Nevertheless, it can cause chronic, lifelong physical and cognitive impairments with severe impact on quality of life, resulting in high healthcare costs [...] Read more.
Background: Traumatic brain injury (TBI) is referred to as a “silent epidemic” due to its limited awareness in the general public. Nevertheless, it can cause chronic, lifelong physical and cognitive impairments with severe impact on quality of life, resulting in high healthcare costs and loss of employment. To evaluate the outcome after mild and moderate TBI, “return to work (RTW)” is a relevant parameter, reflecting the socio-economic consequences of TBI. Our study aims to summarize RTW-rates to raise awareness on the impact of non-severe TBI. Methods: We performed a systematic literature review screening the databases Medline, Embase and Web of Science for studies reporting RTW in mild to moderate TBI. Studies that reported on RTW after mild or moderate TBI (defined by GCS > 9) in adults, with a minimum follow-up of six months were included. Risk of bias was assessed using the QUIPS tool. Results: We included 13 studies with a total 22,550 patients. The overall RTW rate after at least six months, varies between 37% and 98%. Full RTW is reported in six of the included 13 studies and varies between 12% and 67%. In six studies (46%) the RTW-rate by the end of follow-up was ≤60%, with four studies being from high-income countries. Conclusion: Mild and moderate TBI have a high impact on employment rates with diverging rates for RTW even between high-income countries. Increasing the societal awareness of this silent epidemic is of utmost importance and is one of the missions of the Swiss Brain Health Plan. Full article
(This article belongs to the Special Issue Brain Health)
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8 pages, 1424 KiB  
Case Report
Frequently Suspected, Rarely Confirmed: The Complex Diagnostic Journey of Adult-Onset MELAS—Clinical Evaluation and Cost Implications
by Sebastian Finkener, Arkady Ovchinnikov, Ronald Bauer, Michael Diepers and Markus Gschwind
Clin. Transl. Neurosci. 2024, 8(4), 30; https://doi.org/10.3390/ctn8040030 - 30 Nov 2024
Viewed by 870
Abstract
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a rare mitochondrial disorder primarily presenting in pediatric patients, with onset after 40 years being exceptionally rare (1–6%). Here, we report a complex diagnostic journey of a 47-year-old male presenting with new-onset seizures, hemiparesis, [...] Read more.
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a rare mitochondrial disorder primarily presenting in pediatric patients, with onset after 40 years being exceptionally rare (1–6%). Here, we report a complex diagnostic journey of a 47-year-old male presenting with new-onset seizures, hemiparesis, and neurocognitive deficits. Initial work-up, including MRI, CSF analysis, and extensive antibody screening, yielded inconclusive results, prompting differential considerations such as autoimmune encephalitis and neoplastic conditions. Finally muscle biopsy findings, coupled with genetic confirmation of the m.3243A>G mutation in the MT-TL1 gene, ultimately established the diagnosis of MELAS. This case depicts the atypical presentation of adult-onset MELAS without initial lactic acidemia, diabetes, or hearing impairment. The prolonged diagnostic process underscores the challenges of identifying rare diseases under today’s financial and administrative constraints. Still ee emphasize the importance of comprehensive diagnostics in rare cases to advance generall understanding and improve future patient outcomes, also amidst resource limitations. Full article
(This article belongs to the Special Issue Brain Health)
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