Using State-Of-The-Art Proteomics to Understand Infectious Diseases. Novel Clinical Diagnostics, Biomarkers and Drug Targets
A special issue of Diseases (ISSN 2079-9721). This special issue belongs to the section "Infectious Disease".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 4988
Special Issue Editors
Interests: Mass spectrometry imaging (MSI) is a label free technique used to visualize the spatial distribution of biomolecules such as peptides, proteins, lipids or other organic compounds by their molecular masses. In my current work, I develop and employ mass spectrometry imaging and proteomic methodologies to increase our understanding on musculoskeletal and inflammatory pathologies. My aim is to describe future diagnostic or prognostic biomarkers of these diseases
Interests: One of the major hurdles to the success of bacterial pathogens is the host immune response. It is known that bacteria are able to sense and respond to the host environment using different mechanisms. In my current work, using the robust Bordetella spp. murine model a natural host-pathogen infection, I am able to exploit the tools of mouse immunology and forward genetic approaches to test the principles of bacterial pathogenesis and inter-kingdom communication. My goal is to create novel vaccines and therapies to treat multi-drug-resistant bacteria based on the understanding of the mechanisms that bacteria utilize to manipulate host immune response
Special Issues, Collections and Topics in MDPI journals
Division of Infection Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden
Interests: Understanding the mechanisms of the interactions between host and pathogen, their binding and signalling effects, is the main step to develop clinical relevant insights and new immunotherapies to overcome the infectious diseases. Systems biology targets networks, cells, organs and organisms by integrating experimental data with computational and theoretical approaches comprising different disciplines such as, immunoproteomics, in order to obtain a quantitative understanding of complex biological systems in terms of their components and interactions, as well as predictive models for a better understanding of complex systems. My major research goal is to investigate the dynamics of molecular systems in the cellular environment using proteomic approaches. Secondly, discovering biomarkers for a fast-clinical diagnosis and novel drugs or therapies against infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infectious diseases continue to be the number one cause of mortality worldwide, and with the exponential increase in antibiotic resistance, we are facing an era in which the WHO expects around 10 million deaths per year by 2050. This situation creates an imperative need for rapid and precise diagnosis, allowing for quick and efficient treatment that can stop the spread of infectious agents. A challenge in medical microbiology is to develop and apply new experimental approaches that allow for the identification of the microbe as well as its susceptibility profile in a time-sensitive manner. A plethora of novel technologies is being adopted in the diagnostics laboratories to augment specificity and sensitivity and decrease morbidity and mortality. Genomics, transcriptomics, proteomics, and metabolomics are new tools applied to an old problem but reveal that the opportunities to apply novel technologies in the diagnostic field are limitless. Faster and more accurate clinical diagnosis helps to improve health and provide targeted therapies that can be tailored to an individual patient and a specific pathogen.
This Special Issue will focus on translational mass spectrometry-based approaches applied to infectious diseases.
Dr. Berta Cillero-Pastor
Dr. Monica Cartelle Gestal
Dr. Eva Torres-Sangiao
Guest Editors
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Keywords
- Infectious disease
- Tropical diseases
- Microbiology diagnosis
- Mass spectrometry
- Mass spectrometry imaging
- Antimicrobial resistance
- Biomarkers
- Host-pathogen interactions
- Antimicrobial and antiviral therapies
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