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Epidermal and Dermal Skin Substitutes in Burn Care
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Epidermal and Dermal Skin Substitutes in Burn Care

A special issue of European Burn Journal (ISSN 2673-1991).

Deadline for manuscript submissions: closed (1 November 2023) | Viewed by 4783

Special Issue Editors

Dr. Nicco Krezdorn

E-Mail Website
Guest Editor
Clinic for Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany
Interests: ischemia and reperfusion; limb perfusion; limb amputation, replantation and transplantation; vascularized composite allograft—plastic graft
Dr. Marc Jeschke

E-Mail Website
Guest Editor
1. Hamilton Health Sciences Research Insitute, Hamilton, ON, Canada
2. Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, Canada
Interests: burn; trauma; stress response; inflammation; hypermetabolism, including insulin resistance; cell regeneration; gene transfer; stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the area of “Epidermal and Dermal Skin Substitutes” in the treatment of burn injuries.

Advancements and new technologies in a variety of fields, from engineering to 3D printing, have allowed for the development of novel biomedical templates that can serve as temporary or permanent skin substitutes. The improved replacement of skin not only allows for improved functional outcomes but also significantly impacts the aesthetics and psychological outcomes of burn patients. Since the skin is the largest and most affected organ in burns, continuous research on “restitutio ad integrum” and its translation into the clinic is vital to improve outcomes for patients.

Our goal is to assemble an overview of what is currently already possible in the clinic and what will be possible in the future. We welcome submissions related to all matters of skin substitutes, be they biological, alloplastic, xenoplastic, autologous, cultivated, 3D-printed, epidermal, dermal or combined, the integration or replacement of dermal appendages, and innovations in treatment as well as cutting edge technology in burn patients. Experimental and research articles, up-to-date reviews, and commentaries are all welcome.

Dr. Nicco Krezdorn
Dr. Marc Jeschke
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Burn Journal is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 971 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin substitute
  • skin replacement
  • dermal replacement
  • dermal template
  • dermal matrix
  • epidermal template
  • epidermal matrix
  • dermal appendage
  • stem cells
  • three-dimensional printing
  • resorbable matrix
  • resorbable templates
  • temporary templates
  • permanent templates

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Published Papers (2 papers)

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13 pages, 3363 KiB  
Article
High Expansion Auxetic Skin Graft Simulants for Severe Burn Injury Mitigation
by Vivek Gupta, Gurpreet Singh and Arnab Chanda
Eur. Burn J. 2023, 4(1), 108-120; https://doi.org/10.3390/ebj4010011 - 11 Mar 2023
Cited by 3 | Viewed by 2210
Abstract
Burn injuries are commonly treated with split-thickness skin grafting. However, low expansions offered by spilt-thickness skin grafting inhibit the treatment of large and severe burn injuries when limited donor skin is available. To overcome this gap, in this work, it was attempted to [...] Read more.
Burn injuries are commonly treated with split-thickness skin grafting. However, low expansions offered by spilt-thickness skin grafting inhibit the treatment of large and severe burn injuries when limited donor skin is available. To overcome this gap, in this work, it was attempted to study the expansion potential of skin grafts with novel auxetic incisions with rotating rectangle (RR), honeycomb (HC), alternating slit (AS), H-shaped (HS), Y-shaped (YS), and I-shaped (IS) unit cells, through development of skin graft simulants. Clinically relevant biaxial load testing was conducted to estimate the stress–strain response, void area, and meshing ratio. Moreover, hyperelastic constitutive models were employed to characterize the non-linear biomechanical behavior of the skin graft simulants. The maximum void area increase was observed in the HS skin graft simulant, indicating low skin cover. Overall, the IS auxetic skin graft design exhibited meshing ratio higher than traditional grafts (>3:1), low void area and stresses, which can be beneficial for large skin cover and burn wound healing. With further optimization and clinical tests, the auxetic skin graft designs may find a place with the graft manufacturers for fabrication of grafts with better surgical outcomes for severe burn injuries. Full article
(This article belongs to the Special Issue Epidermal and Dermal Skin Substitutes in Burn Care)
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15 pages, 2724 KiB  
Systematic Review
Efficacy and Complications Associated with Acellular Dermal Substitute Use in the Treatment of Acute Burns: A Systematic Review and Meta-Analysis
by Isobel Press, Naiem Moiemen and Zubair Ahmed
Eur. Burn J. 2023, 4(4), 548-562; https://doi.org/10.3390/ebj4040036 - 23 Oct 2023
Cited by 1 | Viewed by 1637
Abstract
Over several decades, skin substitutes have become an essential tool in acute burn surgery, particularly in major burns, where scarce donor tissues can limit the availability of autografts. This systematic review aimed to assess the efficacy, complication rates, and long-term outcomes of acellular [...] Read more.
Over several decades, skin substitutes have become an essential tool in acute burn surgery, particularly in major burns, where scarce donor tissues can limit the availability of autografts. This systematic review aimed to assess the efficacy, complication rates, and long-term outcomes of acellular dermal substitutes in acute burns and compare these to conventional skin grafting methods of coverage. A search of PubMed, Web of Science, and CENTRAL for appropriate randomized controlled trials (RCTs), non-randomized trials, and observational studies was conducted. Following screening, nine RCTs and seven observational studies fulfilled our inclusion and exclusion criteria. Our primary outcomes, which were graft take and incidence of infection, found no significant difference between the substitute and control procedures in a meta-analysis (p = 0.37 and p = 0.87, respectively). For our secondary outcomes, the studies were analyzed via narrative synthesis, which reported variable rates of graft loss and duration of acute hospital stay, from which definitive conclusions could not be drawn due to the heterogeneity in reporting. Despite a high risk of bias in the included studies, the evidence reviewed suggests that the treatment of an acute burn with a substitute may improve scar quality when compared to conventional grafting. This review therefore suggests that acellular dermal substitutes offer a viable method for staging the closure of deep partial- and full-thickness acute burns, although more robust RCTs with less heterogeneity are needed to support these conclusions. Full article
(This article belongs to the Special Issue Epidermal and Dermal Skin Substitutes in Burn Care)
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