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Gastroenterology Insights
Special Issues
Novelties in Colorectal Surgery and Proctology
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Novelties in Colorectal Surgery and Proctology

A special issue of Gastroenterology Insights (ISSN 2036-7422). This special issue belongs to the section "Gastrointestinal Disease".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2350

Special Issue Editors

Dr. Gaetano Gallo

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Guest Editor
Department of Surgery, Sapienza University of Rome, Rome, Italy
Interests: surgery; surgical oncology; laparoscopic surgery; gastrointestinal diseases; functional bowel disorders; pelvic floor disorders; coloproctology
Special Issues, Collections and Topics in MDPI journals
Dr. Marta Goglia

E-Mail Website
Guest Editor
Department of Translational Medicine and Oncology, Sapienza University of Rome, Rome, Italy
Interests: laparoscopic surgery; surgical oncology; coloproctology; pelvic reconstructive surgery; urogynecology
Dr. Paolo Aurello

E-Mail Website
Guest Editor
Department of Surgery, Sapienza University of Rome, Rome, Italy
Interests: surgical oncology; digestive surgery; gastrointestinal neoplasm; postoperative results; oligometastatic disease; long-term oncologic results

Special Issue Information

Dear Colleagues,

Colorectal surgery and proctology stand at the forefront of surgical innovation, with continuous advancements reshaping the landscape of patient care and surgical practice. This Special Issue is dedicated to exploring the latest novelties in this area, aiming to provide a comprehensive overview of the groundbreaking techniques, technologies, and approaches that are redefining the field.

So far, minimally invasive techniques, including laparoscopic and robotic-assisted surgeries, have gained prominence. These methods employ small incisions and specialized instruments, leading to reduced pain, shorter hospital stays, and faster recovery. In the field of functional surgery and proctology, great advances have been made both in diagnostic assessment and in surgical techniques in order to improve the quality of life of patients and ensure a faster return to daily life. Endoscopic surgical techniques in polyp detection and novel approaches to benign disorders such as inflammatory bowel diseases have emerged in recent times. Moreover, personalized treatment approaches have been developed, leveraging genomics for tailored strategies in colorectal cancer care. Today, genetic profiling enables targeted therapies, improving treatment efficacy and patient outcomes. Enhanced Recovery After Surgery (ERAS) protocols are optimizing patient care. Advanced imaging techniques, such as 3D reconstructions from MRI and CT scans, empower surgeons with comprehensive preoperative insights. Moreover, telemedicine has gained traction, enabling remote consultations and follow-ups, enhancing accessibility to care. Furthermore, innovative instruments like advanced staplers and energy devices refine surgical precision. Intraoperative fluorescence imaging, achieved by injecting fluorescent dye to assess blood flow and tissue viability, enhances surgical decision making, reducing complications. Additionally, artificial intelligence applied to preoperative and intraoperative colorectal surgery is giving promising preliminary results.

The aim of this Special Issue is therefore to collect the newest outbreaking innovations in colorectal surgery and proctology, refining techniques and prioritizing patient well-being.

Dr. Gaetano Gallo
Dr. Marta Goglia
Dr. Paolo Aurello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gastroenterology Insights is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence
  • image-guided surgery
  • 3D printing
  • 3D reconstruction
  • ERAS protocol
  • tailored surgery
  • surgical endoscopy
  • proctology
  • hemorrhoids
  • anal fistula
  • core set outcome measures
  • telemedicine
  • technical innovations

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Published Papers (2 papers)

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Research

13 pages, 3108 KiB  
Article
MicroRNA 133A Regulates Squalene Epoxidase Expression in Colorectal Cancer Cells to Control Cell Proliferation and Cholesterol Production
by Ji-Su Mo, Santosh Lamichhane, Grinsun Sharma and Soo-Cheon Chae
Gastroenterol. Insights 2025, 16(1), 5; https://doi.org/10.3390/gastroent16010005 - 9 Jan 2025
Viewed by 944
Abstract
Background/Objectives: Colorectal cancer (CRC) is one of the most common cancers worldwide, with high incidence and mortality rates. MicroRNAs are endogenous and non-coding RNAs that play a pivotal role in the development and progression of various cancers by targeting specific genes. Previously, we [...] Read more.
Background/Objectives: Colorectal cancer (CRC) is one of the most common cancers worldwide, with high incidence and mortality rates. MicroRNAs are endogenous and non-coding RNAs that play a pivotal role in the development and progression of various cancers by targeting specific genes. Previously, we identified MIR133A to be significantly decreased in human CRC tissues. This study aims to identify the relationship with SQLE, one of the candidate target genes of MIR133A, and study their interaction in CRC cells. Methods: Through the luciferase reporter assay, quantitative RT-PCR (qRT-PCR), and Western blot analysis. Results: We identified SQLE as a direct target gene of MIR133A. Using the MIR133A KI cell lines, which knocked-in MIR133A1 or MIR133A2 in CRC cell lines, and CRC cells transfected with siSQLE, we found that MIR133A regulated the proliferation and migration of CRC cells by modulating SQLE-mediated PIK3CA-AKT1 and CYP24A1 signaling. We also found that cholesterol production was regulated by MIR133A in CRC cells. Conclusions: Our results suggest that MIR133A is an important therapeutic target for colorectal cancer. Full article
(This article belongs to the Special Issue Novelties in Colorectal Surgery and Proctology)
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10 pages, 420 KiB  
Article
Screening Colonoscopy Uptake Among Adult Stroke Survivors: Findings from the 2022 BRFSS Data
by Benjamin E. Ansa, Alaina Head, Zola Johnson, Wonder King Selassie Hatekah, Beulah Ansa and Darryl Nettles
Gastroenterol. Insights 2025, 16(1), 2; https://doi.org/10.3390/gastroent16010002 - 6 Jan 2025
Viewed by 809
Abstract
Background/Objectives: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally. Screening for cancer helps to prevent comorbid conditions among individuals with chronic medical conditions, such as stroke. The gold standard for CRC screening is colonoscopy. Stroke is the fifth [...] Read more.
Background/Objectives: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally. Screening for cancer helps to prevent comorbid conditions among individuals with chronic medical conditions, such as stroke. The gold standard for CRC screening is colonoscopy. Stroke is the fifth leading cause of death in the United States and a leading cause of long-term disability. This study examined the prevalence of screening colonoscopy among individuals who reported ever having had a stroke (stroke survivors). Methods: The 2022 Behavioral Risk Factor Surveillance System (BRFSS) data were analyzed for the weighted prevalence and odds of screening colonoscopy uptake among adults aged 45 years and older, based on having had a stroke and socioeconomic status. Results: Almost 6% (n = 16,371) of the adults included in the analysis (N = 285,329) reported having had a stroke, and the weighted prevalence of screening colonoscopy for this group was 73.3% compared to 67.8% for those without stroke. Stroke survivors were 1.3 times more likely to have had a screening colonoscopy compared to those without a history of stroke. Higher odds of screening colonoscopy uptake were observed among stroke survivors that were older than 45–49 years old, with high school or greater than high school education. Stroke survivors that were multiracial and without health insurance coverage had lower odds of screening colonoscopy uptake compared to those that were white and had health insurance coverage, respectively. Conclusions: Though adult stroke survivors, compared to those without a stroke, are more likely to report having had a screening colonoscopy, differences in screening colonoscopy uptake were observed among subgroups of this population based on sociodemographic status. Tailored interventions are needed for increasing screening colonoscopy uptake among disadvantaged subgroups. Full article
(This article belongs to the Special Issue Novelties in Colorectal Surgery and Proctology)
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