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Gastrointestinal Disorders
Special Issues
Current Developments in Esophageal Pathology
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Current Developments in Esophageal Pathology

A special issue of Gastrointestinal Disorders (ISSN 2624-5647).

Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 11015

Special Issue Editor

Dr. Rupert Langer

E-Mail Website
Guest Editor
Institute of Pathology, University of Bern, 3012 Bern, Switzerland
Interests: esophagus; stomach; gastric cancer; esophageal cancer; histology; adenocarcinoma; pathology; molecular pathology

Special Issue Information

Dear Colleagues,

Pathology provides an essential contribution to the management of esophageal diseases. New developments in the clinical management of esophageal disorders influence daily pathology diagnostics, and novel molecular findings are pushing forward research projects.

This Special Issue will cover current developments in pathological aspects of neoplastic and non-neoplastic diseases of the esophagus and the gastroesophageal junction. It will comprise all kinds of pathology-related topics ranging from inflammatory changes to cancer. Contributions regarding histology, cytology, and molecular pathology, covering all fields from basic research to clinical diagnostics, are welcomed.

Assoc. Prof. Rupert Langer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gastrointestinal Disorders is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Esophagus
  • Gastroesophageal junction
  • Esophagitis
  • Esophageal cancer
  • Esophageal adenocarcinoma
  • Esophageal squamous cell carcinoma
  • Pathology
  • Cytology
  • Molecular pathology

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Published Papers (1 paper)

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Research

7 pages, 226 KiB  
Article
Cannabis Use in Patients Presenting to a Gastroenterology Clinic: Associations with Symptoms, Endoscopy Findings, and Esophageal Manometry
by Meet Parikh, Shelini Sookal and Asyia Ahmad
Gastrointest. Disord. 2019, 1(3), 301-307; https://doi.org/10.3390/gidisord1030025 - 1 Jul 2019
Cited by 6 | Viewed by 10373
Abstract
Recreational cannabis use is increasing with its legalization in many states. Animal studies suggest cannabis can reduce transient lower esophageal sphincter relaxations (TLESRS), reflux and vomiting, while human studies report conflicting findings. There are currently no large studies investigating gastrointestinal symptoms in patients [...] Read more.
Recreational cannabis use is increasing with its legalization in many states. Animal studies suggest cannabis can reduce transient lower esophageal sphincter relaxations (TLESRS), reflux and vomiting, while human studies report conflicting findings. There are currently no large studies investigating gastrointestinal symptoms in patients with chronic cannabis use. This was a retrospective case-control study including patients who presented to an outpatient Gastroenterology office, with documented cannabis use. Their main presenting complaint, demographics, frequency and duration of cannabis use, endoscopic and high-resolution esophageal manometry (HREM) with impedance findings were recorded. Cannabis users were more likely to complain of abdominal pain (25% vs. 8%, p < 0.0001), heartburn (15% vs. 9%, p < 0.0001), and nausea & vomiting (7% vs. 1%, p < 0.0001). They were also more likely to have findings of esophagitis (8% vs. 3%, p = 0.0002), non-erosive gastritis (30% vs. 15%, p = 0.0001) and erosive gastritis (14% vs. 3%, p < 0.0001) on upper endoscopy. Cannabis users were more likely to have impaired esophageal bolus clearance (43% vs. 17%, p = 0.04) and a hypertensive lower esophageal sphincter (LES) (29% vs. 7%, p = 0.04). This study is the largest to date evaluating GI complaints of patients with chronic recreational cannabis use. Our results suggest that cannabis use may potentiate or fail to alleviate a variety of GI symptoms which goes against current knowledge. Full article
(This article belongs to the Special Issue Current Developments in Esophageal Pathology)
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