Advances in the 3D Bioprinting of Hydrogels

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 2013

Special Issue Editor


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Guest Editor
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China
Interests: hydrogels; immunomodulatory biomaterials; tissue engineering; regenerative medicine; 3D bioprinting; granular hydrogels

Special Issue Information

Dear Colleagues,

The 3D bioprinting of hydrogels has gained significant attention in recent years due to its potential in revolutionizing organ replacement and drug discovery. Despite the challenges in achieving fully functionalized tissue constructs, recent advances in new bioinks and novel printing methods have brought us closer to this goal. These advancements have significantly enhanced printability, fidelity, and bio-functionality. As a result, there is a growing interest in utilizing 3D bioprinting for manufacturing drug screening platforms and in vivo replacements for damaged tissues.

In this Special Issue of Gels, we aim to provide a platform for showcasing and discussing the latest developments in the rapidly evolving field of 3D bioprinting. This Special Issue will cover a broad range of topics, including (but not limited to) the following:

  • Emerging chemistries;
  • Hydrogel bioink design;
  • Novel bioprinting methods;
  • Biofunctions in printed constructs;
  • Applications of 3D bioprinted constructs.

We invite researchers and experts to contribute their original research articles and reviews to this Special Issue, facilitating the dissemination of valuable knowledge and fostering the progress of 3D bioprinting towards functionalized tissue constructs.

Dr. Shangjing Xin
Guest Editor

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Keywords

  • hydrogels
  • biomaterials
  • 3D bioprinting
  • tissue engineering
  • vascularization
  • cell–material interaction
  • regenerative medicine
  • biofabrication
  • organ-on-a-chip
  • extrusion bioprinting
  • digital light processing

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Published Papers (1 paper)

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Research

11 pages, 2764 KiB  
Article
Hydrogel Extrusion Speed Measurements for the Optimization of Bioprinting Parameters
by Stelian Arjoca, Florina Bojin, Monica Neagu, Andreea Păunescu, Adrian Neagu and Virgil Păunescu
Gels 2024, 10(2), 103; https://doi.org/10.3390/gels10020103 - 27 Jan 2024
Cited by 1 | Viewed by 1620
Abstract
Three-dimensional (3D) bioprinting is the use of computer-controlled transfer processes for assembling bioinks (cell clusters or materials loaded with cells) into structures of prescribed 3D organization. The correct bioprinting parameters ensure a fast and accurate bioink deposition without exposing the cells to harsh [...] Read more.
Three-dimensional (3D) bioprinting is the use of computer-controlled transfer processes for assembling bioinks (cell clusters or materials loaded with cells) into structures of prescribed 3D organization. The correct bioprinting parameters ensure a fast and accurate bioink deposition without exposing the cells to harsh conditions. This study seeks to optimize pneumatic extrusion-based bioprinting based on hydrogel flow rate and extrusion speed measurements. We measured the rate of the hydrogel flow through a cylindrical nozzle and used non-Newtonian hydrodynamics to fit the results. From the videos of free-hanging hydrogel strands delivered from a stationary print head, we inferred the extrusion speed, defined as the speed of advancement of newly formed strands. Then, we relied on volume conservation to evaluate the extrudate swell ratio. The theoretical analysis enabled us to compute the extrusion speed for pressures not tested experimentally as well as the printing speed needed to deposit hydrogel filaments of a given diameter. Finally, the proposed methodology was tested experimentally by analyzing the morphology of triple-layered square-grid hydrogel constructs printed at various applied pressures while the printing speeds matched the corresponding extrusion speeds. Taken together, the results of this study suggest that preliminary measurements and theoretical analyses can simplify the search for the optimal bioprinting parameters. Full article
(This article belongs to the Special Issue Advances in the 3D Bioprinting of Hydrogels)
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