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Gels
Special Issues
Novel Gels for Topical Applications
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Novel Gels for Topical Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 2498

Special Issue Editors

Dr. Mohamadmahdi Samandari

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Connecticut Health Center L7073, Farmington, CT 06030, USA
Interests: tissue engineering; biomaterials; drug delivery; microfluidics; biofabrication; biomedical devices
Special Issues, Collections and Topics in MDPI journals
Dr. Ali Tamayol

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Connecticut Health Center L6085, 263 Farmington Ave., Farmington, CT 06030, USA
Interests: tissue engineering; regenerative medicine; biomanufacturing; wound care; 3D printing
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Adnan Memic

E-Mail Website
Guest Editor
Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Interests: biomaterials; tissue engineering; nanotechnology

Special Issue Information

Dear Colleagues,

We are preparing a Special Issue on “Novel Gels for Topical Applications” to be published in Gels. Polymeric biomaterials and specifically gels have been extensively used in biomedical applications. Particularly, gels have been administrated topically for tissue regeneration (wound healing), drug delivery, and biomarker sensing. The inherent porous structure of gels recapitulates the extracellular matrix architecture, enables mass transport for drug delivery and body fluid sampling, and encourages cellular activity when used as a scaffold for tissue regeneration. Recently, gel-based biomaterials and their fabrication strategies have been engineered to enable facile and immediate preparation and implantation, improved tissue integration and regeneration with patient-specific properties, controlled immune reaction, and spatiotemporally adjusted drug delivery and biomarker sensing.

The current Special Issue is focused on recent advancements in the topical application of gels for biomedical applications. Specifically, we aim to cover novel gels and their fabrication process for wound healing, drug delivery, and biomarker sensing. The topics include but are not limited to “novel hemostatic gel-based bandages”, “patient-specific gels for wound healing”, “immunomodulatory gel dressings”, “gel-enabled targeted and/or stimuli-responsive drug delivery”, “microneedle patches for regeneration, drug delivery, and sensing”, and “in situ fabrication strategies to produce gel-based dressings for drug delivery and tissue regeneration”.

Dr. Mohamadmahdi Samandari
Dr. Ali Tamayol
Prof. Dr. Adnan Memic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • topically administrated gels
  • in situ formed gel dressings
  • smart gel dressings
  • gel-based microneedle arrays
  • topical gels for wound healing

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Published Papers (2 papers)

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16 pages, 7947 KiB  
Article
Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of Melatonin Gel Formulations
by Juan J. Torrado, Brayan J. Anaya, Aytug Kara, Baris Ongoren, Sofía Esteban-Ruiz, Almudena Laguna, Alicia Guillén, Miguel G. Saro and Dolores R. Serrano
Gels 2024, 10(9), 595; https://doi.org/10.3390/gels10090595 - 16 Sep 2024
Viewed by 1289
Abstract
Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, in stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® successfully produced physicochemical stable topical [...] Read more.
Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, in stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® successfully produced physicochemical stable topical formulations. In this work, the impact of the ratio of the oily phase—comprising olive oil and isopropyl myristate from 0 to 20%—was investigated to understand the internal microstructure effect on skin permeability, rheological properties, and stability. The formulations exhibited pseudoplastic behavior, with a significant positive correlation (p-value < 0.1) between the oily phase ratio, viscosity, spreadability, skin adhesiveness, and permeability. Formulations without the oil phase exhibited greater skin permeability. However, higher oily phase content enhanced viscosity, spreadability, and skin adhesion. Given that melatonin primarily degrades through oxidation, incorporating antioxidant excipients in semisolid formulations is crucial for maintaining its chemical stability. A quality by design (QbD) approach was used to assess the impact of four excipients—(a) DL-α-tocopheryl acetate (0.05%), (b) ascorbic acid (0.1%), (c) ethylene diamine tetraacetic acid (0.1%), and (d) sodium metabisulphite (0.5%)—on melatonin’s stability. Our findings indicate that maintaining the physical stability of the formulation with a 20% oil phase is more critical for protecting melatonin from oxidation than merely adding antioxidant excipients. Full article
(This article belongs to the Special Issue Novel Gels for Topical Applications)
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Review

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29 pages, 4274 KiB  
Review
Role of Ionizing Radiation Techniques in Polymeric Hydrogel Synthesis for Tissue Engineering Applications
by Ion Călina, Maria Demeter, Anca Scărișoreanu, Awn Abbas and Muhammad Asim Raza
Gels 2025, 11(1), 47; https://doi.org/10.3390/gels11010047 - 8 Jan 2025
Viewed by 585
Abstract
Hydrogels are widely utilized in industrial and scientific applications owing to their ability to immobilize active molecules, cells, and nanoparticles. This capability has led to their growing use in various biomedical fields, including cell culture and transplantation, drug delivery, and tissue engineering. Among [...] Read more.
Hydrogels are widely utilized in industrial and scientific applications owing to their ability to immobilize active molecules, cells, and nanoparticles. This capability has led to their growing use in various biomedical fields, including cell culture and transplantation, drug delivery, and tissue engineering. Among the available synthesis techniques, ionizing-radiation-induced fabrication stands out as an environmentally friendly method for hydrogel preparation. In alignment with the current requirements for cleaner technologies, developing hydrogels using gamma and electron beam irradiation technologies represents a promising and innovative approach for their biomedical applications. A key advantage of these methods is their ability to synthesize homogeneous three-dimensional networks in a single step, without the need for chemical initiators or catalysts. Additionally, the fabrication process is controllable by adjusting the radiation dose and dose rate. Full article
(This article belongs to the Special Issue Novel Gels for Topical Applications)
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