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Gels
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Gel-Based Novel Wound Dressing
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Gel-Based Novel Wound Dressing

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 6641

Special Issue Editors

Dr. Anna Drabczyk

E-Mail Website
Guest Editor
CBRTP SA - Research and Development Center of Technology for Industry, Ludwika Waryńskiego 3A St., 00-645 Warsaw, Poland
Interests: functional nanomaterials; materials characterization; microstructural analysis; thinfilm fabrication; surface analysis; biomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Sonia Kudłacik-Kramarczyk

E-Mail Website
Guest Editor
Department of Materials Science, Faculty of Materials Engineering and Physics, Cracow University of Technology, 31-864 Krakow, Poland
Interests: innovative biomaterials; nanomaterials for biomedical applications; drug delivery systems, wound dressings
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The task of the dressing materials so far was mainly to provide a protective barrier against the external environment. Currently, the expectations for these materials are much higher. It is desirable to design dressings that will also be able to absorb the wound exudate, prevent bacterial infections, and even support the wound regeneration processes via releasing into the wound various substances with therapeutic properties. Many studies are currently being performed on gel-based wound dressings so as to develop materials demonstrating the mentioned previously properties aiming at designing systems most conducive to wound healing.

Thus the main aim of this Special Issue is to present the synthesis methodology, and the detailed studies on gel-based wound dressings. The works focusing on such dressings modified additionally with various substances enhancing the materials with properties beneficial in terms of the wound healing process are highly welcome.

Dr. Anna Drabczyk
Dr. Sonia Kudłacik-Kramarczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel dressings
  • biological characterization
  • sorption properties
  • drug release
  • mechanical characteristics
  • antimicrobial activity
  • rheological properties

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Published Papers (5 papers)

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Research

21 pages, 5560 KiB  
Article
Hypoxia Preconditioned Serum Hydrogel (HPS-H) Accelerates Dermal Regeneration in a Porcine Wound Model
by Jun Jiang, Tanita Man, Manuela Kirsch, Samuel Knoedler, Kirstin Andersen, Judith Reiser, Julia Werner, Benjamin Trautz, Xiaobin Cong, Selma Forster, Sarah Alageel, Ulf Dornseifer, Arndt F. Schilling, Hans-Günther Machens, Haydar Kükrek and Philipp Moog
Gels 2024, 10(11), 748; https://doi.org/10.3390/gels10110748 - 17 Nov 2024
Viewed by 384
Abstract
Harnessing the body’s intrinsic resources for wound healing is becoming a rapidly advancing field in regenerative medicine research. This study investigates the effects of the topical application of a novel porcine Hypoxia Preconditioned Serum Hydrogel (HPS-H) on wound healing using a minipig model [...] Read more.
Harnessing the body’s intrinsic resources for wound healing is becoming a rapidly advancing field in regenerative medicine research. This study investigates the effects of the topical application of a novel porcine Hypoxia Preconditioned Serum Hydrogel (HPS-H) on wound healing using a minipig model over a 21-day period. Porcine HPS exhibited up to 2.8× elevated levels of key angiogenic growth factors (VEGF-A, PDGF-BB, and bFGF) and demonstrated a superior angiogenic effect in a tube formation assay with human umbilical endothelial cells (HUVECs) in comparison to porcine normal serum (NS). Incorporating HPS into a hydrogel carrier matrix (HPS-H) facilitated the sustained release of growth factors for up to 5 days. In the in vivo experiment, wounds treated with HPS-H were compared to those treated with normal serum hydrogel (NS-H), hydrogel only (H), and no treatment (NT). At day 10 post-wounding, the HPS-H group was observed to promote up to 1.7× faster wound closure as a result of accelerated epithelialization and wound contraction. Hyperspectral imaging revealed up to 12.9% higher superficial tissue oxygenation and deep perfusion in HPS-H-treated wounds at day 10. The immunohistochemical staining of wound biopsies detected increased formation of blood vessels (CD31), lymphatic vessels (LYVE-1), and myofibroblasts (alpha-SMA) in the HPS-H group. These findings suggest that the topical application of HPS-H can significantly accelerate dermal wound healing in an autologous porcine model. Full article
(This article belongs to the Special Issue Gel-Based Novel Wound Dressing)
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17 pages, 3150 KiB  
Article
Potentiality of Antibacterial Gels for the Prophylactic Coating of Hernia Repair Prosthetic Materials
by Bárbara Pérez-Köhler, Selma Benito-Martínez, Celia Rivas-Santos, Verónica Gómez-Gil, Francisca García-Moreno and Gemma Pascual
Gels 2024, 10(11), 687; https://doi.org/10.3390/gels10110687 - 24 Oct 2024
Viewed by 631
Abstract
Prosthetic mesh infection constitutes one of the major postsurgical complications following abdominal hernia repair. Antibacterial coatings represent a prophylactic strategy to reduce the risk of infection. This study assessed the in vitro response of two antibacterial gels made of 1% carboxymethylcellulose (CMC) functionalized [...] Read more.
Prosthetic mesh infection constitutes one of the major postsurgical complications following abdominal hernia repair. Antibacterial coatings represent a prophylactic strategy to reduce the risk of infection. This study assessed the in vitro response of two antibacterial gels made of 1% carboxymethylcellulose (CMC) functionalized with an antiseptic (chlorhexidine, CHX) or an antibiotic (rifampicin, RIF), developed for the coating of polypropylene (PP) meshes for hernia repair. Fragments of a lightweight PP mesh (1 cm2) presoaked in the unloaded or drug-loaded CMC (0.05% CHX; 0.13 mg/mL RIF) were challenged with 106 CFU/mL Staphylococcus aureus (Sa) and methicillin-resistant S. aureus (MRSA). Agar diffusion tests, sonication, turbidimetry, crystal violet staining, scanning electron microscopy and cell viability assays (fibroblasts, mesothelial cells) were performed to evaluate the response of the gels. Both compounds—especially the RIF-loaded gel—exerted a biocidal effect against gram-positive bacteria, developing wide inhibition halos, precluding adhesion to the mesh surface, and hampering bacterial survival in culture. The antibiotic gel proved innocuous, while lower viability was found in cells exposed to the antiseptic (p < 0.05). Together with their fast, affordable, convenient processing and easy application, the results suggest the potential effectiveness of these drug-loaded CMC gels in providing meshes with an antibacterial coating exhibiting great biocide performance. Full article
(This article belongs to the Special Issue Gel-Based Novel Wound Dressing)
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16 pages, 4640 KiB  
Article
In Vivo Evaluation of Wound Healing Efficacy of Gel-Based Dressings Loaded with Pycnogenol™ and Ceratothoa oestroides Extracts
by Andreas Vitsos, Dimitra Ieronymaki, Maria Kostaki, Chara Almpani, Christina Barda, Stefanos Kikionis, Ioannis Sfiniadakis, Paraskevas Dallas and Michail Christou Rallis
Gels 2024, 10(4), 233; https://doi.org/10.3390/gels10040233 - 28 Mar 2024
Cited by 2 | Viewed by 1334
Abstract
Ceratothoa oestroides and French maritime pine bark (Pycnogenol™) extracts are considered promising therapeutic agents in wound healing. This study explores the healing efficacy of composite dressings containing these extracts, aiming to enhance their stability and effectiveness, utilizing a low-temperature vacuum method for producing [...] Read more.
Ceratothoa oestroides and French maritime pine bark (Pycnogenol™) extracts are considered promising therapeutic agents in wound healing. This study explores the healing efficacy of composite dressings containing these extracts, aiming to enhance their stability and effectiveness, utilizing a low-temperature vacuum method for producing Sodium Alginate—Maltodextrin gel dressings. Surgical wounds were inflicted on SKH-hr2 hairless mice. Dressings were loaded with Pycnogenol™ and/or C. oestroides extracts and assessed for their efficacy. Wound healing was primarily evaluated by clinical and histopathological evaluation and secondarily by Antera 3D camera and biophysical measurements. Dressings were stable and did not compromise the therapeutic properties of C. oestroides extract. All interventions were compared to the C. oestroides ointment as a reference product. Most of the wounds treated with the reference formulation and the C. oestrodes dressing had already closed by the 15th day, with histological scores of 7 and 6.5, respectively. In contrast, wounds treated with Pycnogenol™, either alone or in combination with C. oestroides, did not close by the end of the experiment (16th day), with histological scores reaching 15 in both cases. Furthermore, treatment with 5% Pycnogenol™ dressing appeared to induce skin thickening and increase body temperature. The study underscores the wound healing potential of C. oestroides extracts and highlights the need for further research to optimize Pycnogenol™ dosing in topical applications. Full article
(This article belongs to the Special Issue Gel-Based Novel Wound Dressing)
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20 pages, 3726 KiB  
Article
The Influence of Gamma Radiation on Different Gelatin Nanofibers and Gelatins
by Carmen Gaidau, Maria Râpă, Gabriela Ionita, Ioana Rodica Stanculescu, Traian Zaharescu, Rodica-Roxana Constantinescu, Andrada Lazea-Stoyanova and Maria Stanca
Gels 2024, 10(4), 226; https://doi.org/10.3390/gels10040226 - 26 Mar 2024
Cited by 2 | Viewed by 1610
Abstract
Gelatin nanofibers are known as wound-healing biomaterials due to their high biocompatible, biodegradable, and non-antigenic properties compared to synthetic-polymer-fabricated nanofibers. The influence of gamma radiation doses on the structure of gelatin nanofiber dressings compared to gelatin of their origin is little known, although [...] Read more.
Gelatin nanofibers are known as wound-healing biomaterials due to their high biocompatible, biodegradable, and non-antigenic properties compared to synthetic-polymer-fabricated nanofibers. The influence of gamma radiation doses on the structure of gelatin nanofiber dressings compared to gelatin of their origin is little known, although it is very important for the production of stable bioactive products. Different-origin gelatins were extracted from bovine and donkey hides, rabbit skins, and fish scales and used for fabrication of nanofibers through electrospinning of gelatin solutions in acetic acid. Nanofibers with sizes ranging from 73.50 nm to 230.46 nm were successfully prepared, thus showing the potential of different-origin gelatin by-products valorization as a lower-cost alternative to native collagen. The gelatin nanofibers together with their origin gelatins were treated with 10, 20, and 25 kGy gamma radiation doses and investigated for their structural stability through chemiluminescence and FTIR spectroscopy. Chemiluminescence analysis showed a stable behavior of gelatin nanofibers and gelatins up to 200 °C and increased chemiluminescent emission intensities for nanofibers treated with gamma radiation, at temperatures above 200 °C, compared to irradiated gelatins and non-irradiated nanofibers and gelatins. The electron paramagnetic (EPR) signals of DMPO adduct allowed for the identification of long-life HO● radicals only for bovine and donkey gelatin nanofibers treated with a 20 kGy gamma radiation dose. Microbial contamination with aerobic microorganisms, yeasts, filamentous fungi, Staphylococcus aureus, Escherichia coli, and Candida albicans of gelatin nanofibers treated with 10 kGy gamma radiation was under the limits required for pharmaceutical and topic formulations. Minor shifts of FTIR bands were observed at irradiation, indicating the preservation of secondary structure and stable properties of different-origin gelatin nanofibers. Full article
(This article belongs to the Special Issue Gel-Based Novel Wound Dressing)
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23 pages, 8626 KiB  
Article
Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics
by Sanjeevani Deshkar, Purva Yeole, Jayashri Mahore, Ankita Shinde and Prabhanjan Giram
Gels 2023, 9(11), 851; https://doi.org/10.3390/gels9110851 - 27 Oct 2023
Cited by 3 | Viewed by 2030
Abstract
Worldwide, 40 to 50% of women suffer from reproductive tract infections. Most of these infections are mixed infections, are recurrent and difficult to treat with antimicrobials or antifungals alone. For symptomatic relief of infections, oral antimicrobial therapy must be combined with topical therapy. [...] Read more.
Worldwide, 40 to 50% of women suffer from reproductive tract infections. Most of these infections are mixed infections, are recurrent and difficult to treat with antimicrobials or antifungals alone. For symptomatic relief of infections, oral antimicrobial therapy must be combined with topical therapy. The purpose of this work is to optimize and develop a polyelectrolyte complex (PEC) of chitosan/anion for the formulation of posaconazole- and probiotic-loaded vaginal hydrogel inserts with prolonged release and significant mucoadhesion. PECs were prepared using chitosan as cationic and carrageenan, pectin and polycarbophil as anionic polymers via a lyophilization technique. PEC formation was confirmed by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry, by observing changes in its surface, physical and thermal properties. The probiotic, Lactobacillus casei, was added to the PEC during the lyophilization process and the effect on the probiotic viability was studied. The PECs were further compressed along with posaconazole to form hydrogel inserts and optimized using a 32 full-factorial design. The hydrogel inserts were assessed for swelling behavior, drug release, in vitro mucoadhesion and in vitro antifungal activity. The chitosan–pectin hydrogel insert demonstrated excellent mucoadhesion (1.25 N), sustained drug release (88.2 ± 2.4% in 8 h) and a swelling index of 154.7%. The efficacy of hydrogel inserts was evaluated using in vitro study with a co-culture of Lactobacillus casei and Candida albicans. This study revealed an increase in Lactobacilli casei count and a significant drop in the viable count of Candida albicans (4-log reduction in 24 h), indicating the effectiveness of hydrogel inserts in alleviating the fungal infection. Overall, our study demonstrated the potential of the hydrogel insert for preventing vaginal infection and restoring normal vaginal microbiota. Full article
(This article belongs to the Special Issue Gel-Based Novel Wound Dressing)
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