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Gels
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Advances in Biomedical Hydrogels (2nd Edition)
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Advances in Biomedical Hydrogels (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (25 November 2024) | Viewed by 1616

Special Issue Editors

Dr. Keke Wu

E-Mail Website
Guest Editor
Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Interests: tissue engineering; drug delivery; blood purification/adsorption; wearable flexible sensing
Special Issues, Collections and Topics in MDPI journals
Dr. Haishan Shi

E-Mail Website
Guest Editor
School of Stomatology, Jinan University, Guangzhou 510632, China
Interests: tissue engineering; dental materials; drug delivery; multifunctional composite
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to announce the launch of this Special Issue of Gels, “Advances in Biomedical Hydrogels (2nd Edition)”, which is dedicated to recent developments in biomedical hydrogels. As a new kind of biomedical material with excellent biocompatibility, hydrogels have aroused the increasing interest of researchers from the fields of biomedicine and tissue engineering due to their applications in tissue repair, drug delivery, dental materials, blood purification, and wearable sensors. To ensure the wider application of hydrogels in the biomedical field, the design and fabrication of functional hydrogels are of great necessity.

This Special Issue focuses on the modification and biomedical applications of hydrogels. Relevant topics include, but are not limited to, tissue repair, drug delivery, dental materials, blood purification, and wearable sensors. We believe that the topic of this Special Issue can promote new research and new discoveries in the biomedical field of hydrogels. We look forward to receiving your contributions.

Dr. Keke Wu
Dr. Haishan Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • tissue repair
  • drug delivery
  • blood purification
  • wearable sensors

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Published Papers (1 paper)

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Research

19 pages, 8957 KiB  
Article
Formation of Stable Vascular Networks by 3D Coaxial Printing and Schiff-Based Reaction
by Jingxin Shan, Zhiyuan Kong and Xiaohong Wang
Gels 2024, 10(6), 366; https://doi.org/10.3390/gels10060366 - 25 May 2024
Viewed by 1228
Abstract
Vascularized organs hold potential for various applications, such as organ transplantation, drug screening, and pathological model establishment. Nevertheless, the in vitro construction of such organs encounters many challenges, including the incorporation of intricate vascular networks, the regulation of blood vessel connectivity, and the [...] Read more.
Vascularized organs hold potential for various applications, such as organ transplantation, drug screening, and pathological model establishment. Nevertheless, the in vitro construction of such organs encounters many challenges, including the incorporation of intricate vascular networks, the regulation of blood vessel connectivity, and the degree of endothelialization within the inner cavities. Natural polymeric hydrogels, such as gelatin and alginate, have been widely used in three-dimensional (3D) bioprinting since 2005. However, a significant disparity exists between the mechanical properties of the hydrogel materials and those of human soft tissues, necessitating the enhancement of their mechanical properties through modifications or crosslinking. In this study, we aim to enhance the structural stability of gelatin–alginate hydrogels by crosslinking gelatin molecules with oxidized pullulan (i.e., a polysaccharide) and alginate molecules with calcium chloride (CaCl2). A continuous small-diameter vascular network with an average outer diameter of 1 mm and an endothelialized inner surface is constructed by printing the cell-laden hydrogels as bioinks using a coaxial 3D bioprinter. The findings demonstrate that the single oxidized pullulan crosslinked gelatin and oxidized pullulan/CaCl2 double-crosslinked gelatin–alginate hydrogels both exhibit a superior structural stability compared to their origins and CaCl2 solely crosslinked gelatin–alginate hydrogels. Moreover, the innovative gelatin and gelatin–alginate hydrogels, which have excellent biocompatibilities and very low prices compared with other hydrogels, can be used directly for tissue/organ construction, tissue/organ repairment, and cell/drug transportation. Full article
(This article belongs to the Special Issue Advances in Biomedical Hydrogels (2nd Edition))
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