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Gels
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Liposomal and Ethosomal Gels: From Design to Application (2nd Edition)
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Liposomal and Ethosomal Gels: From Design to Application (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 4652

Special Issue Editors

Dr. Maddalena Sguizzato

E-Mail Website
Guest Editor
Department of Chemical, Pharmaceutical and Agricultural Sciences (DoCPAS), University of Ferrara, 44121 Ferrara, Italy
Interests: nanotechnology; topical administration; lipid-based delivery systems; vesicular nanosystems; hydrogels; semisolid formulations; encapsulation; physical chemistry; polymeric matrices
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Rita Cortesi

E-Mail Website
Guest Editor
Department of Chemical, Pharmaceutical and Agricultural Sciences (DoCPAS), University of Ferrara, 44121 Ferrara, Italy
Interests: nanomedicine; liposomes and lipid-based nanosystems; vesicles; microparticles; biomaterials; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to all authors, reviewers, and readers for their responses to the first edition of our Special Issue on “Liposomal and Ethosomal Gels: From Design to Application”. You can access these articles for free via the following link:

Liposomal and Ethosomal Gels: From Design to Application

In the last several decades, lipid-based nanosystems have received a great deal of attention in the field of drug delivery thanks to their “green” properties, related to their biodegradable and non-toxic components, and their easy manufacturing and handling. Among them, vesicular systems such as liposomes, niosomes, and ethosomes are some of the most attractive candidates for improving the topical administration of drugs such as small molecules, peptides, proteins, and bacteriophages thanks to their similarity with the lipids composing the epidermis. Indeed, they have found application in different pathologies, mostly in cutaneous diseases. With the aim of implementing the use of liposomes, niosomes, and ethosomes for skin and mucosae applications, these vesicles need to be thickened. Their inclusion into gelled matrixes based on natural or synthetic polymers or biomaterials represents a promising tool to enhance their adhesive properties and to overcome their viscosity.

This Special Issue aims to summarize the latest advancements in the production, characterization, stability, and application of vesicular systems in gelled formulations. We encourage you to submit research as well as review articles that focus on the use of gel-based liposomes or ethosomes in the fields of medicine, pharmaeutics, or cosmetics.

Dr. Maddalena Sguizzato
Prof. Dr. Rita Cortesi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liposomes
  • niosomes
  • ethosomes
  • hydrogels
  • topical application
  • vesicular gels
  • formulation
  • characterization

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Related Special Issue

Published Papers (3 papers)

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Research

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18 pages, 4485 KiB  
Article
Novel Liposome–Gel Formulations Containing a Next Generation Postbiotic: Characterization, Rheological, Stability, Release Kinetic, and In Vitro Antimicrobial Activity Studies
by Halise Betül Gökçe and İsmail Aslan
Gels 2024, 10(11), 746; https://doi.org/10.3390/gels10110746 - 15 Nov 2024
Viewed by 308
Abstract
In recent years, in addition to the positive effects of probiotics and prebiotics on health, increasing research has shown that postbiotics also have significant potential in the health field. Postbiotics are bioactive components produced by probiotic bacteria during fermentation and may exhibit antimicrobial [...] Read more.
In recent years, in addition to the positive effects of probiotics and prebiotics on health, increasing research has shown that postbiotics also have significant potential in the health field. Postbiotics are bioactive components produced by probiotic bacteria during fermentation and may exhibit antimicrobial activity. This study investigated the antimicrobial effects of liposomal postbiotics formulated in gel. Various postbiotic-containing liposomal systems have been developed and optimized to prepare formulations. Optimized liposomes and liposomal postbiotic-containing gel forms were examined in terms of particle size, polydispersity index, zeta potential, structural properties, encapsulation efficiency, permeability, release profiles, and stability. Finally, the antimicrobial activities of the postbiotics and the optimum gel formulation LG1 were evaluated on Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Enterococcus hirae, and Candida albicans strains using disk diffusion and microdilution methods. The optimum liposome formulation L1 was determined to have a particle size of 185.32 ± 0.80 nm, a polydispersity index of 0.206 ± 0.012, a zeta potential of 35.0 ± 0.5 mV, and an encapsulation efficiency of 17.52%. Its permeability was determined as 51.52% at the end of 6 h. In vitro release studies showed that the drug release profile was in accordance with first-order kinetics and suitable for controlled release. The findings show that formulated postbiotics have similar antimicrobial activity to free postbiotics. These results suggest that liposomal gel formulations support the antimicrobial effects of postbiotics while providing advantages of use. In conclusion, the findings contribute to a better understanding of the antimicrobial potential of postbiotics and lipogelosomal postbiotics and optimize their use in pharmaceutical applications. Full article
(This article belongs to the Special Issue Liposomal and Ethosomal Gels: From Design to Application (2nd Edition))
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19 pages, 3814 KiB  
Article
The Exploitation of Sodium Deoxycholate-Stabilized Nano-Vesicular Gel for Ameliorating the Antipsychotic Efficiency of Sulpiride
by Marwa H. Abdallah, Mona M. Shahien, Alia Alshammari, Somaia Ibrahim, Enas Haridy Ahmed, Hanan Abdelmawgoud Atia and Hemat A. Elariny
Gels 2024, 10(4), 239; https://doi.org/10.3390/gels10040239 - 31 Mar 2024
Cited by 4 | Viewed by 1454
Abstract
The present study explored the effectiveness of bile-salt-based nano-vesicular carriers (bilosomes) for delivering anti-psychotic medication, Sulpiride (Su), via the skin. A response surface methodology (RSM), using a 33 Box–Behnken design (BBD) in particular, was employed to develop and optimize drug-loaded bilosomal vesicles. [...] Read more.
The present study explored the effectiveness of bile-salt-based nano-vesicular carriers (bilosomes) for delivering anti-psychotic medication, Sulpiride (Su), via the skin. A response surface methodology (RSM), using a 33 Box–Behnken design (BBD) in particular, was employed to develop and optimize drug-loaded bilosomal vesicles. The optimized bilosomes were assessed based on their vesicle size, entrapment efficiency (% EE), and the amount of Sulpiride released. The Sulpiride-loaded bilosomal gel was generated by incorporating the optimized Su-BLs into a hydroxypropyl methylcellulose polymer. The obtained gel was examined for its physical properties, ex vivo permeability, and in vivo pharmacokinetic performance. The optimum Su-BLs exhibited a vesicle size of 211.26 ± 10.84 nm, an encapsulation efficiency of 80.08 ± 1.88% and a drug loading capacity of 26.69 ± 0.63%. Furthermore, the use of bilosomal vesicles effectively prolonged the release of Su over a period of twelve hours. In addition, the bilosomal gel loaded with Su exhibited a three-fold increase in the rate at which Su transferred through the skin, in comparison to oral-free Sulpiride. The relative bioavailability of Su-BL gel was almost four times as high as that of the plain Su suspension and approximately two times as high as that of the Su gel. Overall, bilosomes could potentially serve as an effective technique for delivering drugs through the skin, specifically enhancing the anti-psychotic effects of Sulpiride by increasing its ability to penetrate the skin and its systemic bioavailability, with few adverse effects. Full article
(This article belongs to the Special Issue Liposomal and Ethosomal Gels: From Design to Application (2nd Edition))
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Review

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26 pages, 4074 KiB  
Review
Liposome–Hydrogel Composites for Controlled Drug Delivery Applications
by Roya Binaymotlagh, Farid Hajareh Haghighi, Laura Chronopoulou and Cleofe Palocci
Gels 2024, 10(4), 284; https://doi.org/10.3390/gels10040284 - 22 Apr 2024
Cited by 5 | Viewed by 2431
Abstract
Various controlled delivery systems (CDSs) have been developed to overcome the shortcomings of traditional drug formulations (tablets, capsules, syrups, ointments, etc.). Among innovative CDSs, hydrogels and liposomes have shown great promise for clinical applications thanks to their cost-effectiveness, well-known chemistry and synthetic feasibility, [...] Read more.
Various controlled delivery systems (CDSs) have been developed to overcome the shortcomings of traditional drug formulations (tablets, capsules, syrups, ointments, etc.). Among innovative CDSs, hydrogels and liposomes have shown great promise for clinical applications thanks to their cost-effectiveness, well-known chemistry and synthetic feasibility, biodegradability, biocompatibility and responsiveness to external stimuli. To date, several liposomal- and hydrogel-based products have been approved to treat cancer, as well as fungal and viral infections, hence the integration of liposomes into hydrogels has attracted increasing attention because of the benefit from both of them into a single platform, resulting in a multifunctional drug formulation, which is essential to develop efficient CDSs. This short review aims to present an updated report on the advancements of liposome–hydrogel systems for drug delivery purposes. Full article
(This article belongs to the Special Issue Liposomal and Ethosomal Gels: From Design to Application (2nd Edition))
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