Hydrogels, Microgels and Nanogels Emerging Platforms for Drug Delivery, Antibacterial Properties and Tissue Engineering

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1815

Special Issue Editors


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Guest Editor
Institute of Chemical Research of Catalonia (ICIQ-CERCA), Avinguda dels Països Catalans, 43007 Tarragona, Spain
Interests: hydrogels; polypeptides; drug delivery; antibacterial properties; ring opening polymerization; polyesters

E-Mail Website
Guest Editor
Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: peptide synthesis; non-proteinogenic amino acids; self-assembly; drug delivery; medical imaging; theranostic platforms
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Special Issue Information

Dear Colleagues,

This Special Issue on “Hydrogels, Microgels and Nanogels Emerging Platforms for Drug Delivery, Antibacterial Properties and Tissue Engineering” is dedicated to recent achievements in gel materials that can revolutionize the potential of these networks to be used for advanced bio applications. In this respect, a broad range of subjects and advancements about chemistry, physics, rheology, material properties and applications of hydrogels, microgels and nanogels can be presented and discussed highlighting their importance in these fields.

The use of state-of-the-art materials that can offer a plethora of advantages has opened avenues the last years about their exploitation in applications improving the life expectancy and quality of life, dealing with modern problems of bacterial resistance, drug efficiency and restoring or replacing biological tissues. The contribution of gels is crucial, due to their unique properties of swelling, cross-linking, viscoelasticity, as well as, responsiveness to external stimuli. Additionally, the utilization of a big family of compounds, like synthetic polymers, polysaccharides and proteins has led to gels with high biocompatibility and/or biodegradation. Furthermore, the progress in the research about gel materials has intensified the collaboration between scientists with different background, since gels constitute a science subject that attracts the interest of researchers from many areas, studying and understanding them from many aspects.

This Special Issue will contain representative examples, illustrating new opportunities and developments. Its goal is the burst of interest about these materials that will lead to further discoveries.

Dr. Dimitrios Skoulas
Dr. Paula M. T. Ferreira
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • microgels
  • nanogels
  • drug delivery
  • antibacterial properties
  • tissue engineering

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Published Papers (2 papers)

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Research

20 pages, 7024 KiB  
Article
Dual-Action Gemcitabine Delivery: Chitosan–Magnetite–Zeolite Capsules for Targeted Cancer Therapy and Antibacterial Defense
by Yuly Andrea Guarín-González, Gerardo Cabello-Guzmán, José Reyes-Gasga, Yanko Moreno-Navarro, Luis Vergara-González, Antonia Martin-Martín, Rodrigo López-Muñoz, Galo Cárdenas-Triviño and Luis F. Barraza
Gels 2024, 10(10), 672; https://doi.org/10.3390/gels10100672 - 21 Oct 2024
Viewed by 853
Abstract
Cancer and infectious diseases are two of the world’s major public health problems. Gemcitabine (GEM) is an effective chemotherapeutic agent against several types of cancer. In this study, we developed macrocapsules incorporating GEM into a chitosan matrix blended with magnetite and zeolite by [...] Read more.
Cancer and infectious diseases are two of the world’s major public health problems. Gemcitabine (GEM) is an effective chemotherapeutic agent against several types of cancer. In this study, we developed macrocapsules incorporating GEM into a chitosan matrix blended with magnetite and zeolite by ionic gelation. Physicochemical characterization was performed using HRTEM-ED, XRD, FESEM–EDS, FT-IR, TGA, encapsulation efficiency (%E.E.), and release profiles at pHs 7.4 and 5.0. Cell viability tests against A549 and H1299 cell lines, and microbiological properties against staphylococcal strains were performed. Our results revealed the successful production of hemispherical capsules with an average diameter of 1.22 mm, a rough surface, and characteristic FT-IR material interaction bands. The macrocapsules showed a high GEM encapsulation efficiency of over 86% and controlled release over 24 h. Cell viability assays revealed that similar cytotoxic effects to free GEM were achieved with a 45-fold lower GEM concentration, suggesting reduced dosing requirements and potentially fewer side effects. Additionally, the macrocapsules demonstrated potent antimicrobial activity, reducing Staphylococcus epidermidis growth by over 90%. These results highlight the macrocapsules dual role as a chemotherapeutic and antimicrobial agent, offering a promising strategy for treating lung cancer in patients at risk of infectious diseases or who are immunosuppressed. Full article
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13 pages, 3132 KiB  
Article
Shear-Thinning Extrudable Hydrogels Based on Star Polypeptides with Antimicrobial Properties
by Dimitrios Skoulas, Muireann Fallon, Katelyn J. Genoud, Fergal J. O’Brien, Deirdre Fitzgerald Hughes and Andreas Heise
Gels 2024, 10(10), 652; https://doi.org/10.3390/gels10100652 - 11 Oct 2024
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Abstract
Hydrogels with low toxicity, antimicrobial potency and shear-thinning behavior are promising materials to combat the modern challenges of increased infections. Here, we report on 8-arm star block copolypeptides based on poly(L-lysine), poly(L-tyrosine) and poly(S-benzyl-L-cysteine) blocks. Three star block copolypeptides were synthesized with poly(S-benzyl-L-cysteine) [...] Read more.
Hydrogels with low toxicity, antimicrobial potency and shear-thinning behavior are promising materials to combat the modern challenges of increased infections. Here, we report on 8-arm star block copolypeptides based on poly(L-lysine), poly(L-tyrosine) and poly(S-benzyl-L-cysteine) blocks. Three star block copolypeptides were synthesized with poly(S-benzyl-L-cysteine) always forming the outer block. The inner block comprised either two individual blocks of poly(L-lysine) and poly(L-tyrosine) or a statistical block copolypeptide from both amino acids. The star block copolypeptides were synthesized by the Ring Opening Polymerization (ROP) of the protected amino acid N-carboxyanhydrides (NCAs), keeping the overall ratio of monomers constant. All star block copolypeptides formed hydrogels and Scanning Electron Microscopy (SEM) confirmed a porous morphology. The investigation of their viscoelastic characteristics, water uptake and syringe extrudability revealed superior properties of the star polypeptide with a statistical inner block of L-lysine and L-tyrosine. Further testing of this sample confirmed no cytotoxicity and demonstrated antimicrobial activity of 1.5-log and 2.6-log reduction in colony-forming units, CFU/mL, against colony-forming reference laboratory strains of Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, respectively. The results underline the importance of controlling structural arrangements in polypeptides to optimize their physical and biological properties. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Injectable photocrosslinkable polysaccharide hydrogels for stem cell delivery and tissue regeneration


Author: Xiaojie Lin, Jacob Beizel, Yang Zhou, Avik Som, Miqin Zhang
Affiliation: UW

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