Recent Research on Medical Hydrogels

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 924

Special Issue Editors


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Guest Editor
Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Iasi, 700028 Iasi, Romania
Interests: electrospinning; polymers; hydrogels; wound healing; nanotechnology
Smart Polymeric Biomaterials—Biomaterials and Tissue Engineering @ Campus Group T Leuven, KU Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium
Interests: smart polymers; electrospinning; wound dressings; tendon repair; alginate; biomaterials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Polymer, Mechanical & Design, Technological University of the Shannon, Athlone, Co. Westmeath, Ireland
Interests: polymers; hydrogels; organic chemistry; drug delivery; smart materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This issue aims to display recent advances in hydrogel-related research, as well as its important contributions to healthcare applications. Hydrogels are medically regarded as a supportive matrix and, due to their distinctive properties, can be used under various forms, such as gels, sheets, or scaffolds, and can display their purposes after being injected, processed into scaffolds, administered orally, or topically. Further, research topics include the synthesis and characterization of the hydrogels, as well as their different medical uses such as wound dressings for various types of wounds, diagnosis applications (sensors, functional coatings), tissue engineering, and regenerative medicine. An important aspect when developing a new hydrogel material is to improve biocompatibility, biodegradability, and mechanical properties. On the other hand, hydrogels may be used, for example, as 3D scaffolds for cell culture and tissue regeneration by incorporating bioactive molecules or cells into the hydrogel matrix or by obtaining the hydrogels from decellularized extracellular matrices. Another advantage of hydrogels is that they can be designed as drug delivery systems suitable for controlled and targeted release. Also, they may be chosen in formulation studies to improve drug absorption because of their mucoadhesive and bioadhesive properties. Moreover, recent research also focused on the role of hydrogels in personalized disease modelling which can be achieved by mimicking physiological conditions of specific diseases.

Dr. Ionescu Oana-Maria
Dr. Arn Mignon
Prof. Dr. Clement Higginbotham
Guest Editors

Manuscript Submission Information

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Keywords

  • hydrogels
  • polymers
  • wound healing
  • tissue engineering
  • biomedical applications

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Published Papers (1 paper)

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Research

16 pages, 2213 KiB  
Article
Activated Charcoal-Alginate Platform for Simultaneous Local Delivery of Bioactive Agents: At the Nexus of Antimicrobial and Cytotoxic Activity of Zn2+ Ions
by Andrea Osmokrovic, Ivan Jancic, Zeljko Zizak, Marina Milenkovic and Bojana Obradovic
Gels 2024, 10(11), 724; https://doi.org/10.3390/gels10110724 - 8 Nov 2024
Viewed by 454
Abstract
Antimicrobial resistance (AMR) is a global public health threat that affects cancer patients more than the general population. In this work, a composite system based on Zn-alginate hydrogel and activated charcoal (AC) particles that, upon contact with physiological fluids, simultaneously releases bioactive agents [...] Read more.
Antimicrobial resistance (AMR) is a global public health threat that affects cancer patients more than the general population. In this work, a composite system based on Zn-alginate hydrogel and activated charcoal (AC) particles that, upon contact with physiological fluids, simultaneously releases bioactive agents (Zn2+ and AC particles impregnated with povidone–iodine) was designed to locally address specific problems characteristic for malignant wounds (MWs). This composite was comprehensively investigated in vitro regarding its morphology (field-emission scanning electron microscopy), Zn2+ release (flame atomic absorption spectrometry), iodine adsorption and desorption from AC particles (energy dispersive X-ray analysis and UV–visible spectroscopy) as well as its antimicrobial and antitumor activity. With respect to the ongoing AMR crises, antimicrobial activity was tested against a wide range of wild multi-drug resistant bacterial and yeast strains, all isolated from patient wounds. Since Zn2+ ions proved to be selectors of resistant strains of bacteria, the synergistic activity of AC particles and adsorbed iodine was shown to be crucial for excellent antibacterial activity. On the other hand, the synergy of AC particles and Zn2+ ions showed an equally strong antifungal effect. In addition, antimicrobial concentrations of Zn2+ ions showed cytotoxic activity against two cancer cell lines derived from cancers affecting skin either as metastatic cancer (breast cancer MDA-MB-453 cell line) or primary cancer of the skin (malignant melanoma Fem-X cell line), which enables Zn2+ ions to be further investigated as potent local agents targeting malignant cells. Full article
(This article belongs to the Special Issue Recent Research on Medical Hydrogels)
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