Genetics and Genomics of Blood Disorders
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 33755
Special Issue Editors
Interests: genetics of hematologic diseases; acute leukemias; minimal residual disease (MRD); next generation sequencing (NGS)
Special Issue Information
Dear Colleagues,
Blood disorders comprise a large number of oncologic and non-oncologic diseases affecting all hematologic cell lineages. Some genetic alterations have been known as the cause of these diseases for many decades. Conversely, other specific genetic features have been linked to these diseases only recently.
Technological advances have had a huge impact on the discovery of new genomic features and are useful in defining the sequential acquisition of genetic alteration during disease evolution. Furthermore, the effort to correlate genetic abnormalities and patients’ outcomes is helping us to understand the impact of such alterations on disease evolution.
Many different types of DNA damage, such as translocations, deletions, duplications, and mutations, are known to be causative of pathology when affecting genes coding for proteins involved in basic cell pathways, as well as in specific hematologic functions. Less information is available for such alterations when they occur in regulatory regions of the genome, e.g., in the huge amount of so-called “non-coding DNA”. Much is known; however, much more is yet to be known.
This Special Issue in Genes on “Genetics and Genomics of Blood Disorders” will provide an overview of the known genetic features of different hematologic diseases and recent observation in this expanding field.
Dr. Orietta Spinelli
Dr. Silvia Salmoiraghi
Guest Editors
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Keywords
- hematologic disease
- gene mutations
- genomic alterations
- next generation sequencing (NGS)
- molecular alterations
- minimal residual disease (MRD)
- disease evolution
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