Translational Cancer Genomics by Next Generation Sequencing and Molecular-Barcoding Technique
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (22 November 2020) | Viewed by 7968
Special Issue Editors
Interests: lung cancer; sequencing; immunotherapy; thoracic surgery; liquid biopsy; microbiome; genome analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the past decade, there have been incredible advances that have improved clinical management of cancer and the disease outcome in the field of molecular oncology. Despite this, the drug therapy cure rate at the advanced stage for many types of cancers remains inadequately high, and development of further innovative therapeutic strategies is currently desired. Recent advances in sequencing technology, notably the introduction of next-generation sequencing and molecular barcoding techniques, have enabled rapid, efficient, low-cost, and precise sequencing. Furthermore, extensive application of these latest technologies to basic cancer research has facilitated the in-depth molecular characterization of cancer from various perspectives (oncogenesis, tumor phylogeny, progression, metastasis, treatment response, etc.) with higher precision than before.
This Special Issue aims to publish original research papers and review articles related to advances in basic research on cancer genomics that are very close to the stage of clinical application. A particular focus will be given to research using sequencing data expected to contribute to the development of novel cancer diagnostics and treatment techniques (including gene therapies) as well as new medical devices and drugs, such as studies on circulating tumor DNA, fusion gene, intratumor heterogeneity, tumor mutation burden, and the microbiome. Furthermore, papers discussing cancer cell responses to immunotherapy based on sequence data will also be considered.
Dr. Taichiro Goto
Dr. Yosuke Hirotsu
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- intratumor heterogeneity
- tumor mutation burden
- gene mutation
- immune checkpoint
- biomarker
- circulating tumor DNA
- microbiome
- fusion gene
- sequencing
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