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Innovative Treatments for Post-traumatic Stress Disorder (PTSD)
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Innovative Treatments for Post-traumatic Stress Disorder (PTSD)

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 28 February 2025 | Viewed by 8827

Special Issue Editor

Prof. Dr. Wissam El-Hage

E-Mail Website
Guest Editor
Regional Trauma Center, UMR 1253 iBrain, Clinical Investigation Center CIC1415, CHRU de Tours, Université de Tours, INSERM, Tours, France
Interests: PTSD; treatment-resistant depression; PNES
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Post-traumatic stress disorder (PTSD) is a trauma-related mental health condition triggered by experiencing or witnessing a frightening or distressing event. PTSD is prevalent in high-income countries (up to 10% of lifetime prevalence), is twice more common in females than in males, and co-occurs with other psychiatric disorders and physical conditions. Symptoms may include flashbacks, nightmares, avoidance, severe anxiety, negative changes in thinking and mood, and changes in physical and emotional reactions with considerable functional impairment. In recent decades, effective evidence-based treatments for PTSD have been developed. In spite of these encouraging developments, finding effective, relevant, and personalized treatments for patients with PTSD, including  all types of trauma and post-traumatic morbidities, remains challenging. 

We are pleased to invite you to contribute to this Special Issue, ‘Innovative treatments for post-traumatic stress disorder (PTSD)’, which welcomes original research articles and reviews that either (i) describe successful prevention strategies and/or early interventions, (ii) promote effective programs to increase resilience to war-related or civilian-related trauma, (iii) describe innovative therapeutic strategies, (iv) evaluate the effectiveness of conventional or innovative psychotherapeutic treatments, or (v) evaluate the effectiveness of pharmacotherapeutic treatments and strategies for PTSD. 

The goal of this Special Issue is to foster innovation and the more widespread use of evidence-based approaches, and to share insights obtained from field experience, inter-cultural views, and academic knowledge, in order to enhance access to care for PTSD. 

I look forward to receiving your contributions.

You may choose our Joint Special Issue in Brain Sciences.

Prof. Dr. Wissam El-Hage
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • trauma
  • PTSD
  • therapy
  • prevention
  • innovation
  • resilience
  • policies

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Published Papers (4 papers)

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Research

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19 pages, 697 KiB  
Article
The Relationship of the Psychological Resilience and Stress Coping Level of Health Personnel Working in Hospitals After Kahramanmaraş-Based Earthquakes with Traumatic Stress
by Mehmet Koca, Serdar Deniz and Feyza İnceoğlu
Healthcare 2025, 13(3), 301; https://doi.org/10.3390/healthcare13030301 - 2 Feb 2025
Viewed by 181
Abstract
Objectives: In this study, we aimed to examine the indirect and direct effects of the stress experienced by health workers after an earthquake on their psychological resilience. Methods: This study was conducted using the Structural Equation Model on 315 employees serving in hospitals [...] Read more.
Objectives: In this study, we aimed to examine the indirect and direct effects of the stress experienced by health workers after an earthquake on their psychological resilience. Methods: This study was conducted using the Structural Equation Model on 315 employees serving in hospitals in Kahramanmaraş, Gaziantep, Şanlıurfa, Diyarbakır, Adana, Adıyaman, Osmaniye, Hatay, Kilis, Malatya, and Elazığ (11 provinces) that were most affected by the earthquake. Results: The study group consisted of 58.4% (n = 184) women and 41.6% (n = 131) men. The mean score on the Psychological Resilience Scale was 71.74, the mean score on the Coping with Stress Scale was 87.17, the mean score on the Traumatic Stress Symptom Scale was 44.04, and the mean score on the Disability Scale was 3.75. Psychological resilience had a statistically significant negative effect on traumatic stress symptoms (β1 = −0.26; p = 0.001 < 0.05). There was a statistically significant positive relationship between coping with stress and psychological resilience (β1 = 0.52; p = 0.001 < 0.05). Conclusions: It was concluded that an increase in an individual’s psychological resilience will increase the level of coping with stress, and the traumatic stress symptoms of individuals with an increased level of coping with stress will decrease. Full article
(This article belongs to the Special Issue Innovative Treatments for Post-traumatic Stress Disorder (PTSD))
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17 pages, 490 KiB  
Article
EMDR–Teens–cPTSD: Efficacy of Eye Movement Desensitization and Reprocessing in Adolescents with Complex PTSD Secondary to Childhood Abuse: A Case Series
by Julie Rolling, Morgane Fath, Thomas Zanfonato, Amaury Durpoix, Amaury C. Mengin and Carmen M. Schröder
Healthcare 2024, 12(19), 1993; https://doi.org/10.3390/healthcare12191993 - 6 Oct 2024
Viewed by 2196
Abstract
Background: Mental healthcare for children and adolescents with a history of childhood abuse constitutes a major public health issue. Indeed, abuse exposes children to severe and complex post-traumatic stress disorder (cPTSD) but also to neurodevelopmental and psychological repercussions impacting the developmental trajectory. [...] Read more.
Background: Mental healthcare for children and adolescents with a history of childhood abuse constitutes a major public health issue. Indeed, abuse exposes children to severe and complex post-traumatic stress disorder (cPTSD) but also to neurodevelopmental and psychological repercussions impacting the developmental trajectory. Trauma-focused care is essential to avoid the chronicization of symptoms and disorders. Objective: The aim of this prospective case series study was to investigate the efficacy of eye movement desensitization and reprocessing (EMDR) on complex post-traumatic symptoms and associated psychiatric disorders in adolescents with a history of abuse. Method: Twenty-two adolescents, aged 12 to 17, who had been abused during childhood were included. All adolescents met ICD-11 criteria for complex PTSD. Subjective measures of PTSD and associated psychiatric disorders were taken before (T0) and after 3 months of EMDR therapy (T1). Results: The average PTSD symptom score on the CPTS-RI significantly decreased from 40.2 to 34.4 after EMDR, indicating improvement in post-traumatic symptoms. A significant decrease in the average depression score (CDI from 18.2 at T0 to 10.6 at T1), anxiety score (R–CMAS from 21.3 at T0 to 13.3 at T1), emotional regulation score (ALS from 29 at T0 to 10.8 at T1), insomnia score (ISI from 18.5 at T0 to T1 of 9.2 at T1), and harmful use of alcohol and drugs score (ADOSPA from 2.3 at T0 to 0.3 at T1) was observed after EMDR therapy, as well as an increase in quality of life (CBCL 4–16 score from 57.9 at T0 to 77.4 at T1). Conclusions: The results of this study are encouraging and suggest that EMDR may be effective in the symptom management reducing post-traumatic symptoms and certain comorbid disorders frequently seen in adolescents who have experienced childhood abuse. Further research is needed on adolescent populations suffering from cPTSD (e.g., randomized controlled trials with control groups and other therapies or evaluating the action of the different phases of the study). Full article
(This article belongs to the Special Issue Innovative Treatments for Post-traumatic Stress Disorder (PTSD))
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12 pages, 1586 KiB  
Article
Clinical Efficiency and Acceptability of EMDR and MOSAIC Therapy for PTSD
by Deborah Flatot-Blin, Arnaud Rey, Flavie Derynck, Olivier Fossard and Stephanie Khalfa
Healthcare 2023, 11(15), 2226; https://doi.org/10.3390/healthcare11152226 - 7 Aug 2023
Cited by 2 | Viewed by 3880
Abstract
Eye movement desensitization and reprocessing (EMDR) therapy is one of the therapies recommended by the World Health Organization (2013) to treat posttraumatic stress disorder (PTSD). Although efficient, repeated exposure to the traumatic memory may reduce its acceptability to patients. The therapy “eye movement [...] Read more.
Eye movement desensitization and reprocessing (EMDR) therapy is one of the therapies recommended by the World Health Organization (2013) to treat posttraumatic stress disorder (PTSD). Although efficient, repeated exposure to the traumatic memory may reduce its acceptability to patients. The therapy “eye movement and alternate stimulation for brain integration” (MOSAIC in French) was developed to improve acceptability and reduce pain by drawing on the patient’s internal resources. MOSAIC therapy focuses on the body sensations that the patient wants to experience and avoids having to relive the traumatic memories. This observational study aimed to compare the clinical efficiency of EMDR and MOSAIC therapy for PTSD and to measure the well-being generated by both therapies. Twenty-six PTSD patients (17 females and 9 males, mean age 37.01 years, SD = 13.06) received treatment by psychiatrists and/or psychologists trained with EMDR or MOSAIC therapy. Both patient groups achieved a significant decrease in PTSD symptoms as measured with the PCL-5. However, fewer sessions were required with the MOSAIC therapy than with EMDR therapy. As expected, the level of well-being experienced by the patient during the therapy, assessed using the Lickert scale, was higher with MOSAIC than with EMDR therapy from the first session. These findings provide the first evidence of the efficacy of MOSAIC therapy treatment, which now needs to be corroborated in a larger randomized clinical trial. Full article
(This article belongs to the Special Issue Innovative Treatments for Post-traumatic Stress Disorder (PTSD))
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13 pages, 614 KiB  
Study Protocol
July 14th 2016 Nice Terrorist Attack Court Trial: A Protocol on Sleep Quality and Somatic Symptoms as Markers of Risk for Traumatic Reactivation in Adolescents Exposed to This Attack
by Radia Zeghari, Morgane Gindt, Jokthan Guivarch, Philippe Auby, Philippe Robert, Julie Rolling, Carmen Schröder, Petri Valo, Florence Askenazy and Arnaud Fernandez
Healthcare 2023, 11(22), 2953; https://doi.org/10.3390/healthcare11222953 - 12 Nov 2023
Cited by 2 | Viewed by 1454
Abstract
The court trial of the 14th of July 2016 terrorist attack in Nice (France) opened in September 2022 and ended in December 2022. Engaging in court proceedings, whether as a victim or a witness, can lead to a significant risk of traumatic reactivation [...] Read more.
The court trial of the 14th of July 2016 terrorist attack in Nice (France) opened in September 2022 and ended in December 2022. Engaging in court proceedings, whether as a victim or a witness, can lead to a significant risk of traumatic reactivation (i.e., the re-emergence of post-traumatic stress symptoms). The present protocol aimed to improve knowledge of the pathophysiology of traumatic reactivation due to the media coverage of the trial by assessing sleep disturbances and somatic symptoms that could reappear if there is a traumatic reactivation. Method and Analysis: This is a monocentric longitudinal study, with recruitment solely planned at the Nice Pediatric Psychotrauma Center (NPPC). We intended to include 100 adolescents aged 12 to 17 years who were directly or indirectly exposed to the attack and included in the “14-7” program). Assessments began one month before the trial, in August 2022, and were scheduled once a month until the end of the trial. A smartwatch recorded sleep activity. Somatic and PTSD symptoms and sleep were assessed through validated questionnaires. The main analyses comprised the variance and regression analyses of predictors of clinical evolution over time. Ethics and Dissemination: The National Ethics Committee “NORD OUEST III” approved the “14-7” program protocol (number 2017-A02212-51). The specific amendment for this research was approved in April 2022 by the same national ethical committee. Inclusions started in August 2022. Full article
(This article belongs to the Special Issue Innovative Treatments for Post-traumatic Stress Disorder (PTSD))
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