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2nd Edition: Neuroprotection and Treatment in Intensive Care and Perioperative Medicine

Special Issue Editor


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Guest Editor
2nd Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, 20-081 Lublin, Poland
Interests: perioperative medicine; intensive care medicine; pharmacology; fluid therapy; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first Special Issue on Neuroprotection and Treatment in Intensive Care and Perioperative Medicine was a great success. We received a handful of exciting papers focusing on this crucial topic, and we are now ready to continue our project. In this second Special Issue in the International Journal of Environmental Research and Public Health, we would like to focus on: 

  • Postoperative delirium, with particular attention to interventions aiming at reducing its incidence.
  • Neuroprotective compounds and their role in the ICU and the perioperative setting.
  • Cognitive impairment and dementia following ischemic stroke and cardiac arrest.
  • Role of neuroprotection in patients suffering from traumatic brain injury.
  • New findings on the mechanisms of neuroprotection in the preclinical setting.

Dr. Mirosław Czuczwar
Guest Editor

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Keywords

  • perioperative medicine
  • neuroprotection
  • ICU
  • traumatic brain injury
  • anesthesia
  • stroke
  • sudden cardiac arrest

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Related Special Issue

Published Papers (1 paper)

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Research

14 pages, 1958 KiB  
Article
Dexmedetomidine Increases MMP-12 and MBP Concentrations after Coronary Artery Bypass Graft Surgery with Extracorporeal Circulation Anaesthesia without Impacting Cognitive Function: A Randomised Control Trial
by Michał Kowalczyk, Anna Panasiuk-Kowalczyk, Adam Stadnik, Małgorzata Guz, Marek Cybulski, Witold Jeleniewicz, Andrzej Stepulak and Magdalena Kwiatosz-Muc
Int. J. Environ. Res. Public Health 2022, 19(24), 16512; https://doi.org/10.3390/ijerph192416512 - 8 Dec 2022
Cited by 3 | Viewed by 1804
Abstract
Postoperative neurological deficits remain a concern for patients undergoing cardiac surgeries. Even minor injuries can lead to neurocognitive decline (i.e., postoperative cognitive dysfunction). Dexmedetomidine may be beneficial given its reported neuroprotective effect. We aimed to investigate the effects of dexmedetomidine on brain injury [...] Read more.
Postoperative neurological deficits remain a concern for patients undergoing cardiac surgeries. Even minor injuries can lead to neurocognitive decline (i.e., postoperative cognitive dysfunction). Dexmedetomidine may be beneficial given its reported neuroprotective effect. We aimed to investigate the effects of dexmedetomidine on brain injury during cardiac surgery anaesthesia. This prospective observational study analysed data for 46 patients who underwent coronary artery bypass graft surgery with extracorporeal circulation between August 2018 and March 2019. The patients were divided into two groups: control (CON) with typical anaesthesia and dexmedetomidine (DEX) with dexmedetomidine infusion. Concentrations of the biomarkers matrix metalloproteinase-12 (MMP-12) and myelin basic protein (MBP) were measured preoperatively and at 24 and 72 h postoperatively. Cognitive evaluations were performed preoperatively, at discharge, and 3 months after discharge using Addenbrooke’s Cognitive Examination version III (ACE-III). The primary endpoint was the ACE-III score at discharge. Increased MMP-12 and MBP concentrations were observed in the DEX group 24 and 72 h postoperatively. No significant differences in ACE-III scores were observed between the groups at discharge; however, the values were increased when compared with initial values after 3 months (p = 0.000). The current results indicate that the administration of dexmedetomidine as an adjuvant to anaesthesia can increase MMP-12 and MBP levels without effects on neurocognitive outcomes at discharge and 3 months postoperatively. Full article
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