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Prevention and Healthcare of Chronic Kidney Disease
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Prevention and Healthcare of Chronic Kidney Disease

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Infectious Diseases, Chronic Diseases, and Disease Prevention".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 8375

Special Issue Editor

Dr. Gijs Van Pottelbergh

E-Mail Website
Guest Editor
Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium
Interests: chronic kidney disease; environmental health; multimorbidity; integrated care

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is a frequent chronic disease with major impact on the health of patients and major interaction with other diseases and therapies. Additionally, the cost of renal replacement therapy is high for health insurance. Although there has been recent progress in the treatment of CKD, prevention is essential to decrease kidney damage.

Some risk factors for developing CKD, such as hypertension, primary kidney diseases, systemic diseases, and diabetes, are well studied and documented. However, there are some factors, such as lifestyle, air pollution, green spaces, nearby traffic, etc., and especially the combined effects of all these factors on the evolution of the kidney function and the development of CKD, which are less studied. In this Special Issue, we would like to focus on this research domain of environmental and lifestyle factors and their influence on the evolution of kidney function and/or the development of CKD. We welcome epidemiological studies and all types of intervention studies.

Dr. Gijs Van Pottelbergh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • air pollutions
  • lifestyle
  • indoor pollutants
  • environmental factors
  • multi-morbidity

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Published Papers (4 papers)

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Research

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9 pages, 302 KiB  
Article
Knowledge and Competence Regarding the Management of Chronic Kidney Disease among Family Medicine Professionals in the Eastern Province of Saudi Arabia: A Cross-Sectional Study
by Abdullah Almaqhawi
Int. J. Environ. Res. Public Health 2024, 21(7), 880; https://doi.org/10.3390/ijerph21070880 - 6 Jul 2024
Viewed by 1089
Abstract
Diabetes is a significant risk factor for chronic kidney disease (CKD) and a primary cause of global morbidity and mortality, resulting in significant costs to healthcare systems. The management of diabetic CKD in the primary care setting remains an ongoing challenge despite the [...] Read more.
Diabetes is a significant risk factor for chronic kidney disease (CKD) and a primary cause of global morbidity and mortality, resulting in significant costs to healthcare systems. The management of diabetic CKD in the primary care setting remains an ongoing challenge despite the current best practices in the quality of care. This study evaluated family medicine physicians’ knowledge and confidence regarding managing CKD in the Eastern Province of Saudi Arabia. A self-administered online questionnaire was distributed to physicians through various social media sites and email lists. The largest number of participants reported a full confidence in knowing kidney disease stages, blood pressure targets and the importance of urine albumin–creatinine ratio testing. Overall, 71.8% of physicians reported a high confidence level, followed by 23.9% reporting average and 4.2% reporting low confidence. Being younger and working at PHC were identified as significant predictors of increased confidence. Although most of the physicians reported a high confidence in managing CKD patients, the need for improvement was evident. Age and workplace institutions were the greater contributors to physicians’ confidence. Continuous education among healthcare practitioners is crucial to updating knowledge and providing optimum quality of care among this group of patients. Full article
(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)
10 pages, 1617 KiB  
Article
Combination of Risks of BMI and Health-Related Lifestyles on Kidney Function in the Prediabetic Japanese Population: A Prospective Cohort Study
by Jou-Yin Chen, Shiqi Deng and Yukiko Wagatsuma
Int. J. Environ. Res. Public Health 2023, 20(7), 5338; https://doi.org/10.3390/ijerph20075338 - 30 Mar 2023
Cited by 1 | Viewed by 1640
Abstract
Diabetic overweight patients are more likely to show the progression of kidney damage than the general population. The majority of people in the early stages of kidney damage do not recognize the importance of risk modification, mainly due to the asymptomatic nature of [...] Read more.
Diabetic overweight patients are more likely to show the progression of kidney damage than the general population. The majority of people in the early stages of kidney damage do not recognize the importance of risk modification, mainly due to the asymptomatic nature of the disease. This study aimed to examine specific risk combinations of lifestyle and BMI regarding the deterioration of kidney function and to explore whether there are gender-based differences among the prediabetic population. Prediabetic participants with normal kidney function were identified via annual health examination from April 2016 to March 2019. The information on health status and lifestyle was collected at enrollment. The study subjects were followed until March 2021 to observe the progression of kidney damage. There were 2241 participants enrolled in this study. Smoking (HR = 3.5, p < 0.001), eating snacks (HR = 3.2, p < 0.001), not engaging in regular exercise (HR = 2.9, p < 0.001), and not having adequate sleep (HR = 3.0, p < 0.001) showed accelerated risks for kidney damage progression among the prediabetic population in males. These lifestyle effects were not observed in females. In conclusion, risk-based modification of lifestyle behavior is important to prevent kidney function damage among the overweight prediabetic population in males. Full article
(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)
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12 pages, 1840 KiB  
Article
Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
by Mami Ishida, Keiichi Matsuzaki, Hitoshi Suzuki, Yusuke Suzuki, Takashi Kawamura, Yoshinori Marunaka and Taku Iwami
Int. J. Environ. Res. Public Health 2022, 19(18), 11466; https://doi.org/10.3390/ijerph191811466 - 12 Sep 2022
Cited by 1 | Viewed by 1885
Abstract
Microscopic hematuria is being increasingly recognized as a major indicator of kidney deterioration. Persistent hematuria may better detect estimated glomerular filtration rate (eGFR) deterioration and potential glomerulonephritis. We conducted a retrospective cohort study to investigate the associations between persistent hematuria: the frequency or [...] Read more.
Microscopic hematuria is being increasingly recognized as a major indicator of kidney deterioration. Persistent hematuria may better detect estimated glomerular filtration rate (eGFR) deterioration and potential glomerulonephritis. We conducted a retrospective cohort study to investigate the associations between persistent hematuria: the frequency or consistency of positive dipstick hematuria defined by the preceding 3 years urinalyses, and eGFR deterioration over 5 years and abnormal urinalyses suggesting potential glomerulonephritis (hematuria 1+ or higher, 2+ or higher, proteinuria, and hematuria and proteinuria) 5 years later, among adult participants with positive dipstick hematuria at baseline in a large-scale Japanese health checkup setting (n = 2104). There was no significant association between persistent hematuria and eGFR deterioration over 5 years. The higher the frequency of preceding hematuria, the greater the RR of hematuria 5 years later; RRs of hematuria with preceding thrice, twice, or once hematuria were 3.64 [95% CI, 3.11–4.25], 2.97 [95% CI, 2.52–3.51], or 1.91 [95% CI, 1.58–2.30] for “hematuria 1+ or higher,” and 7.13 [95% CI, 5.17–9.83], 4.26 [95% CI, 3.02–6.02], or 2.23 [95% CI, 1.52–3.27] for “hematuria 2+ or higher”. The presence of both hematuria and proteinuria 5 years later was only associated with preceding thrice hematuria (RR: 2.35 [95% CI, 1.37–4.03]). In conclusion, persistent hematuria for 3 years was associated with hematuria and proteinuria that were suggesting glomerulonephritis, but not associated with eGFR deterioration over 5 years. Multiple dipstick urinalyses over years can add some values to detect potential glomerulonephritis as an early sign of chronic kidney diseases. Full article
(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)
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Review

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24 pages, 947 KiB  
Review
Lupus, DNA Methylation, and Air Pollution: A Malicious Triad
by Leen Rasking, Céline Roelens, Ben Sprangers, Bernard Thienpont, Tim S. Nawrot and Katrien De Vusser
Int. J. Environ. Res. Public Health 2022, 19(22), 15050; https://doi.org/10.3390/ijerph192215050 - 15 Nov 2022
Cited by 5 | Viewed by 2812
Abstract
The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day; however, genetic, epigenetic, and environmental factors have been implicated to be involved in disease pathogenesis. Recently, it was demonstrated that in systemic lupus erythematosus (SLE) patients, interferon-regulated genes are hypomethylated in [...] Read more.
The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day; however, genetic, epigenetic, and environmental factors have been implicated to be involved in disease pathogenesis. Recently, it was demonstrated that in systemic lupus erythematosus (SLE) patients, interferon-regulated genes are hypomethylated in naïve CD4+ T cells, CD19+ B lymphocytes, and CD14+ monocytes. This suggests that interferon-regulated genes may have been epigenetically poised in SLE patients for rapid expression upon stimulation by different environmental factors. Additionally, environmental studies have identified DNA (hypo)methylation changes as a potential mechanism of environmentally induced health effects in utero, during childhood and in adults. Finally, epidemiologic studies have firmly established air pollution as a crucial SLE risk factor, as studies showed an association between fine particulate matter (PM2.5) and traditional SLE biomarkers related to disease flare, hospital admissions, and an increased SLEDAI score. In this review, the relationship between aberrant epigenetic regulation, the environment, and the development of SLE will be discussed. Full article
(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)
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