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Genetic Biomarkers as a Tool to Improve the Quality of Life

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Department of Biochemistry, Molecular Biology and Physiology, Universidad de Valladolid, Campus Duques de Soria, 42004 Soria, Spain
Interests: epidemiology; nutrition; gerontology; healthy aging; diet pharmacogenetics; cancer genetics; genetic polymorphisms and pharmacoepidemiology; biomarkers; sarcopenia
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Special Issue Information

Dear Colleagues,

Several decades of intensive research have originated multiple factors or biomarkers that are likely to be helpful in the diagnosis, characterization, and therapy selection. A deep understanding of the relative relevance of each biomarker will be key to efficiently diagnose diseases, adverse drug responses and direct our patients towards the drugs more likely to be of benefit based on their particular profile. There is an enormous effort to identify, characterize, and validate meaningful biomarkers because its successful development will represent a step forward in the individualization of diagnosis, therapy or monitoring and improving quality of life.

Prof. Dr. Zoraida Verde Rello
Guest Editor

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Keywords

  • biomarkers
  • genetic variants
  • pharmacogenetics
  • toxicity
  • adverse events
  • quality of life
  • well-being
  • strength
  • drugs.

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Published Papers (1 paper)

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Review

15 pages, 561 KiB  
Review
Contribution of Genetic Polymorphisms in Human Health
by Pieranna Chiarella, Pasquale Capone and Renata Sisto
Int. J. Environ. Res. Public Health 2023, 20(2), 912; https://doi.org/10.3390/ijerph20020912 - 4 Jan 2023
Cited by 21 | Viewed by 3647
Abstract
Human health is influenced by various factors; these include genetic inheritance, behavioral lifestyle, socioeconomic and environmental conditions, and public access to care and therapies in case of illness, with the support of the national health system. All these factors represent the starting point [...] Read more.
Human health is influenced by various factors; these include genetic inheritance, behavioral lifestyle, socioeconomic and environmental conditions, and public access to care and therapies in case of illness, with the support of the national health system. All these factors represent the starting point for the prevention and promotion of a healthy lifestyle. However, it is not yet clear to what extent these factors may actually affect the health of an entire population. The exposures to environmental and occupational factors are several, most of which might be poorly known, contributing to influencing individual health. Personal habits, including diet, smoking, alcohol, and drug consumption, together with unhealthy behaviors, may inevitably lead people to the development of chronic diseases, contributing to increasing aging and decreasing life expectancy. In this article, we highlight the role of susceptibility biomarkers, i.e., the genetic polymorphisms of individuals of different ethnicities, with particular attention to the risk factors in the response to specific exposures of Europeans. Moreover, we discuss the role of precision medicine which is representing a new way of treating and preventing diseases, taking into account the genetic variability of the individual with each own clinical history and lifestyle. Full article
(This article belongs to the Special Issue Genetic Biomarkers as a Tool to Improve the Quality of Life)
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