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Uncommon Lesions of the Oral Mucosa and Rehabilitation of the...
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Uncommon Lesions of the Oral Mucosa and Rehabilitation of the Masticatory Function

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 76977

Special Issue Editors

Prof. Dr. Matteo Trimarchi

E-Mail Website
Leading Guest Editor
Unità Operativa di Otorinolaringoiatrica, Fondazione San Raffaele, via Olgettina 60 , 20132, Milano, Italy
Interests: oral pathology; oral surgery; rhinology; functional sinus surgery; odontogenic sinus disease; lacrimal disorders; maxillo-facial disorders and midline destructive lesions
Dr. Stefano Bondi

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Assistant Guest Editor
Unità Operativa di Otorinolaringoiatrica, Fondazione San Raffaele, via Olgettina 60 , 20132, Milano, Italy
Interests: oral cancer;oral pathology;head-neck cancer;oral and neck surgery;sleep disorders and salivary gland surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Giacomo Bertazzoni

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Assistant Guest Editor
Unità Operativa di Otorinolaringoiatrica, ASST Cremona, Italy
Interests: Oral cancer; oral surgery; rhinology; head-neck cancer; salivary gland surgery
Dr. Alessandro Vinciguerra

E-Mail Website
Assistant Guest Editor
Unità Operativa di Otorinolaringoiatrica, Fondazione San Raffaele, via Olgettina 60 , 20132, Milano, Italy
Interests: oral cancer; oral pathology; rhinology; sinus surgery; lacrimal disorder; orbit pathology; orbit surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral health and masticatory function are important factors of general health with a great influence on the quality of life. Even if the lesions of these anatomical structures are common, several uncommon pathologies occur with divergent general consensus on the best management available. We would like to invite you to submit a contribution to a Special Issue on uncommon lesions of the oral mouth and rehabilitation of the masticatory function in the International Journal of Environmental Research and Public Health.

Considering uncommon lesions of the oral cavity, both tumoral and infective/granulomatous, the therapeutic approach of these lesions is based on both the control of risk factors, design of new preventive strategies and the early detection of these pathologies. In fact, if properly and promptly treated, it may have positive consequences on individuals and the community in term of economic influence and community health.

Masticatory function is essential in this particular cohort of patients. In particular, rehabilitation of post-traumatic, post-oncological and atrophic jaws with oral prostheses and implants are essential to improve the quality of life.

This Special Issue seeks research papers on the proper diagnosis and treatment of rare oral diseases, as well as original studies on the rehabilitation of masticatory function.

Prof. Matteo Trimarchi
Dr. Stefano Bondi
Dr. Giacomo Bertazzoni
Dr. Alessandro Vinciguerra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oral health
  • Oral pathology
  • Oral surgery
  • Oral manifestations of vasculitis
  • Oral manifestations of granulomatous diseases
  • Oral Infection
  • Primary prevention
  • Oral healthcare
  • Risk factors
  • Oral cancer
  • Oral implants
  • Oral prostheses

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Published Papers (5 papers)

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14 pages, 2818 KiB  
Review
Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis
by Silvio Abati, Chiara Bramati, Stefano Bondi, Alessandra Lissoni and Matteo Trimarchi
Int. J. Environ. Res. Public Health 2020, 17(24), 9160; https://doi.org/10.3390/ijerph17249160 - 8 Dec 2020
Cited by 173 | Viewed by 41012
Abstract
Oral cancer (OC) is an uncommon malignancy in Western countries, being one of the most common cancers in some high-risk areas of the world. It is a largely preventable cancer, since most of the different risk factors identified, such as tobacco use, alcohol [...] Read more.
Oral cancer (OC) is an uncommon malignancy in Western countries, being one of the most common cancers in some high-risk areas of the world. It is a largely preventable cancer, since most of the different risk factors identified, such as tobacco use, alcohol consumption, and betel nut chewing, are behaviors that increase the likelihood of the disease. Given its high mortality, early diagnosis is of utmost importance. Prevention and the anticipation of diagnosis begin with identification of potentially malignant lesions of the oral mucosa and with local conditions promoting chronic inflammation. Therefore, every lesion must be recognized promptly and treated adequately. The clinical recognition and evaluation of oral mucosal lesions can detect up to 99% of oral cancers/premalignancies. As stated by the World Health Organization, any suspicious lesion that does not subside within two weeks from detection and removal of local causes of irritation must be biopsied. Surgical biopsy remains the gold standard for diagnosis of oral cancer. Adjunctive tools have been developed and studied to help clinicians in the diagnostic pathway, such as toluidine blue vital staining and autofluorescence imaging. In the near future other methods, i.e., identification of salivary markers of progression may help in reducing mortality due to oral cancer. Full article
(This article belongs to the Special Issue Uncommon Lesions of the Oral Mucosa and Rehabilitation of the Masticatory Function)
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7 pages, 3191 KiB  
Case Report
Solitary Extramedullary Plasmacytoma Presenting as Asymptomatic Palatal Erythroplakia: Report of a Case
by Francesca Lalla, Alessandro Vinciguerra, Alessandra Lissoni, Gianluigi Arrigoni, Francesca Lira Luce and Silvio Abati
Int. J. Environ. Res. Public Health 2021, 18(7), 3762; https://doi.org/10.3390/ijerph18073762 - 4 Apr 2021
Cited by 3 | Viewed by 15708
Abstract
Solitary plasmacytoma (SP) is a rare malignant tumor of plasma cells with no systemic spread; however, when it disseminates and affects multiple skeletal sites, it is called multiple myeloma (MM). The etiology of solitary plasmacytoma is unknown, with two possible subtypes: solitary extramedullary [...] Read more.
Solitary plasmacytoma (SP) is a rare malignant tumor of plasma cells with no systemic spread; however, when it disseminates and affects multiple skeletal sites, it is called multiple myeloma (MM). The etiology of solitary plasmacytoma is unknown, with two possible subtypes: solitary extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP). We present a case of EMP arising as asymptomatic erythroplakia of the palate, which is rarely described in the literature. The definitive diagnosis was obtained with immunohistochemical studies, after which the lesion was subjected to excisional biopsy. At present, after two years of close follow-up, the patient has shown no signs of relapse or conversion to MM. The uniqueness of the case highlights the possibility of an atypical EMP lesion in the head and neck, thus posing a diagnostic and therapeutic challenge for physicians. Full article
(This article belongs to the Special Issue Uncommon Lesions of the Oral Mucosa and Rehabilitation of the Masticatory Function)
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11 pages, 4977 KiB  
Case Report
Mucosal Melanoma of the Hard Palate: Surgical Treatment and Reconstruction
by Stefano Bondi, Alessandro Vinciguerra, Alessandra Lissoni, Nathalie Rizzo, Diego Barbieri, Pietro Indelicato and Silvio Abati
Int. J. Environ. Res. Public Health 2021, 18(7), 3341; https://doi.org/10.3390/ijerph18073341 - 24 Mar 2021
Cited by 3 | Viewed by 7517
Abstract
Mucosal melanomas of the head and neck region are uncommon pathologies that can affect the oral cavity, and are characterized by a high rate of mortality. Considering the lack of knowledge regarding risk and prognostic factors, current best clinical practice is represented by [...] Read more.
Mucosal melanomas of the head and neck region are uncommon pathologies that can affect the oral cavity, and are characterized by a high rate of mortality. Considering the lack of knowledge regarding risk and prognostic factors, current best clinical practice is represented by a large surgical excision with disease-free margins, eventually associated with a reconstructive flap. Indeed, given the frequent necessity of postoperative radiotherapy and fast healing process, a reconstruction of the surgical gap is advisable. Even if several flaps have been most commonly used, the submental island flap represents a valid alternative thanks to local advantages and similar oncologic outcomes compared to free flaps. Full article
(This article belongs to the Special Issue Uncommon Lesions of the Oral Mucosa and Rehabilitation of the Masticatory Function)
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10 pages, 1193 KiB  
Case Report
Cocaine-Induced Midline Destructive Lesions: A Real Challenge in Oral Rehabilitation
by Andrea Rampi, Alessandro Vinciguerra, Stefano Bondi, Nicoletta Stella Policaro and Giorgio Gastaldi
Int. J. Environ. Res. Public Health 2021, 18(6), 3219; https://doi.org/10.3390/ijerph18063219 - 20 Mar 2021
Cited by 10 | Viewed by 7521
Abstract
Cocaine abuse is associated with severe local effects on mucosal and osteocartilaginous structures, with a centrifugal spreading pattern from the nose, a condition known as cocaine-induced midline destructive lesions (CIMDL). When the soft or hard palate is affected, a perforation may occur, with [...] Read more.
Cocaine abuse is associated with severe local effects on mucosal and osteocartilaginous structures, with a centrifugal spreading pattern from the nose, a condition known as cocaine-induced midline destructive lesions (CIMDL). When the soft or hard palate is affected, a perforation may occur, with subsequent oro-nasal reflux and hypernasal speech. Both diagnosis and therapy (surgical or prosthetic) constitute a serious challenge for the physician. The cases of three patients affected by cocaine-induced palatal perforation and treated with a palatal obturator at San Raffaele Dentistry department between 2016 and 2019 are presented. In addition, the literature was reviewed in search of papers reporting the therapeutic management in patients affected by cocaine-induced palatal perforation. All the patients in our sample suffered from oro-nasal reflux and hypernasal speech, and reported a significant impact on interpersonal relationships. The results at the delivery of the obturator were satisfactory, but the duration of such results was limited in two cases, as the progression of the disease necessitated continuous modifications of the product, with a consequent increase in costs and a reduction in patient satisfaction. In conclusion, the therapy for palatal defects in CIMDL includes both reconstructive surgery and prosthetic obturators, the latter being the only possibility in the event of active disease. It successfully relieves symptoms, but the long-term efficacy is strongly related to the level of disease activity. Full article
(This article belongs to the Special Issue Uncommon Lesions of the Oral Mucosa and Rehabilitation of the Masticatory Function)
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11 pages, 2099 KiB  
Case Report
IgG4-Related Disease of the Oral Cavity. Case Series from a Large Single-Center Cohort of Italian Patients
by Andrea Rampi, Marco Lanzillotta, Gaia Mancuso, Alessandro Vinciguerra and Lorenzo Dagna
Int. J. Environ. Res. Public Health 2020, 17(21), 8179; https://doi.org/10.3390/ijerph17218179 - 5 Nov 2020
Cited by 10 | Viewed by 4064
Abstract
A series of destructive and tumefactive lesions of the oral cavity are increasingly recognized as part of the IgG4-related disease (IgG4-RD) spectrum. We herein examined the clinical, serological, radiological, and histological features of a series of patients referred to our clinic because of [...] Read more.
A series of destructive and tumefactive lesions of the oral cavity are increasingly recognized as part of the IgG4-related disease (IgG4-RD) spectrum. We herein examined the clinical, serological, radiological, and histological features of a series of patients referred to our clinic because of oral cavity lesions ultimately attributed to IgG4-RD. In particular, we studied 6 consecutive patients out of 200 patients referred to the immunology outpatient unit who presented with erosive and/or tumefactive lesions of the oral cavity. All patients underwent serum IgG4 measurement, nasal endoscopy, radiological studies, and histological evaluation of tissue specimens. The histological studies included immunostaining studies to assess the number of IgG4+ plasma cells/High-Power Field (HPF) for calculation of the IgG4+/IgG+ plasma cell ratio. Six patients (3% of the entire cohort) were diagnosed with IgG4-RD of the oral cavity based on histological evaluation. A major complaint at presentation was oral discomfort due to bulging mass. A mild to no increase in serum IgG4 was observed. Different patterns of organ involvement were associated with oral lesions. Five patients were treated with immunosuppressive therapy and two patients promptly responded to B-cell depletion with rituximab. Watchful waiting was decided in one patient with no major clinical symptoms. Involvement of the oral cavity is an infrequent manifestation of IgG4-RD but should be taken into consideration as a possible differential diagnosis of tumefactive or erosive lesions once neoplastic conditions are excluded. A histological examination of biopsy samples from the oral cavity represents the mainstay for diagnosis of IgG4-RD. Full article
(This article belongs to the Special Issue Uncommon Lesions of the Oral Mucosa and Rehabilitation of the Masticatory Function)
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