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Diagnosing and Treating Psychotic Disorders in Old Age
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Diagnosing and Treating Psychotic Disorders in Old Age

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Aging".

Deadline for manuscript submissions: closed (5 December 2022) | Viewed by 8833

Special Issue Editors

Dr. Alexandre González-Rodríguez

E-Mail Website
Guest Editor
Department of Mental Health, Mutua Terrassa University Hospital, University of Barcelona (UAB), Terrassa, Barcelona, Spain
Interests: psychopathology; clinical psychiatry; psychoeducation; cognitive disorders; neuroscience
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Manuel A. Franco-Martin

E-Mail Website
Guest Editor
1. Faculty of Psychology, Campus Ciudad Jardín, University of Salamanca, Avenida de la Merced, 109, 37005 Salamanca, Spain
2. Department of Psychiatry and Mental Health, Río Hortega University Hospital, Calle Dulzaina, 2, 47012 Valladolid, Spain
3. Department of Psychiatry, Zamora Provincial Hospital, Calle Hernán Cortés, 40, 49071 Zamora, Spain
Interests: psychogeriatrics; clinical psychiatry; dementia; psychoeducation; neuroscience
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Current research shows that elderly patients are at high risk for the development of psychotic symptoms. Several diagnostic categories can be associated with the presence of psychotic symptoms. This is the case for schizophrenia, delusional disorder, mood disorders, dementia, delirium, substance-use disorders, and other medical or neurologic conditions.

The recent literature shows that the efficacy of antipsychotic medications has been confined to the reduction in delusions and hallucinations, and to the diminishing of behavioral disturbances. Age alters the kinetics and dynamics of psychotropic medications, and drugs other than antipsychotics are being tested to treat cognitive, affective, and negative psychotic symptoms.

Knowledge of drug–drug interactions and comorbidities is of special interest for clinicians, as they contribute to higher mortality rates in older psychotic populations. The unmet needs of older patients must be assessed by a comprehensive history and accurate physical and mental health examinations. Adverse events should be checked and worked up, and polypharmacy should be avoided if possible. The role of psychological interventions in treating psychotic disorders in elderly patients is crucial.

This Special Issue aims to cover aspects of the pharmacological and non-pharmacological therapy of psychosis in older populations, including the treatment of schizophrenia, delusional disorder and other major disorders, dementia, delirium, and other medical conditions presenting psychotic symptoms. We invite authors to submit original articles and review articles.

Dr. Alexandre González-Rodríguez
Prof. Dr. Manuel Franco-Martin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psychogeriatrics
  • psychosis
  • old age, pharmacological treatment
  • antipsychotics

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Published Papers (2 papers)

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Review

8 pages, 307 KiB  
Review
Subjective Overview of Accelerated Aging in Schizophrenia
by Mary V. Seeman
Int. J. Environ. Res. Public Health 2023, 20(1), 737; https://doi.org/10.3390/ijerph20010737 - 31 Dec 2022
Cited by 8 | Viewed by 2360
Abstract
Schizophrenia, like many other human diseases, particularly neuropsychiatric diseases, shows evidence of accelerated brain aging. The molecular nature of the process of aging is unknown but several potential indicators have been used in research. The concept of accelerated aging in schizophrenia took hold [...] Read more.
Schizophrenia, like many other human diseases, particularly neuropsychiatric diseases, shows evidence of accelerated brain aging. The molecular nature of the process of aging is unknown but several potential indicators have been used in research. The concept of accelerated aging in schizophrenia took hold in 2008 and its timing, pace, determinants and deterrents have been increasingly examined since. The present overview of the field is brief and selective, based on diverse studies, expert opinions and successive reviews. Current thinking is that the timing of age acceleration in schizophrenia can occur at different time periods of the lifespan in different individuals, and that antipsychotics may be preventive. The majority opinion is that the cognitive decline and premature death often seen in schizophrenia are, in principle, preventable. Full article
(This article belongs to the Special Issue Diagnosing and Treating Psychotic Disorders in Old Age)
14 pages, 868 KiB  
Review
Delusional Disorder in Old Age: A Hypothesis-Driven Review of Recent Work Focusing on Epidemiology, Clinical Aspects, and Outcomes
by Alexandre González-Rodríguez, Mary V. Seeman, Eduard Izquierdo, Mentxu Natividad, Armand Guàrdia, Eloïsa Román and José A. Monreal
Int. J. Environ. Res. Public Health 2022, 19(13), 7911; https://doi.org/10.3390/ijerph19137911 - 28 Jun 2022
Cited by 10 | Viewed by 5212
Abstract
The theme, strength, and duration of a delusion are considered important in distinguishing one psychosis of old age from another. Research results, however, are mostly based on studies conducted on one form of psychosis, namely schizophrenia. The aim of this hypothesis-driven narrative review [...] Read more.
The theme, strength, and duration of a delusion are considered important in distinguishing one psychosis of old age from another. Research results, however, are mostly based on studies conducted on one form of psychosis, namely schizophrenia. The aim of this hypothesis-driven narrative review is to gather clinically important information about the psychosis identified as delusional disorder (DD), as it affects persons of senior age. We hypothesized that DD becomes relatively prevalent in old age, especially in women; and that it is associated with demonstrable brain changes, which, in turn, are associated with cognitive defects and poor pharmacological response, thus increasing the risk of aggression and suicide. Computerized searches in PubMed and ClinicalTrials.gov were conducted using the following search terms: (delusional disorder) AND (elderly OR old OR aged OR psychogeriatrics). A total of 16 recent studies (including case reports) were reviewed. Our hypotheses could not be definitively confirmed because research evidence is lacking. In order to improve eventual outcomes, our literature search demonstrates the need for more targeted, well-designed studies. Full article
(This article belongs to the Special Issue Diagnosing and Treating Psychotic Disorders in Old Age)
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