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A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 18917

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Prof. Dr. Sy Duong-Quy

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1. Division of Pulmonary, Allergy and Critical Care Medicine, Penn State Health, Milton S. Hershey Medical Center and Pennsylvania State University College of Medicine, Hershey, PA, USA
2. Respiratory and Lung Functional Exploration Department, Cochin Hospital, Paris Descartes University, Paris, France
3. Bio-Medical Research Center, Lam Dong Medical College, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
Interests: allergic rhinitis; anosmia; asthma; snoring; obstructive sleep apnea; exhaled nitric oxide; COVID-19; long COVID-19
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Prof. Dr. Timothy J Craig

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Section of Allergy and Immunology, Department of Medicine and Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA
Interests: alpha-1-antitrypsin deficiency; asthma; COPD; hereditary angioedema

Prof. Dr. Isabella Annesi-Maesano

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Guest Editor

1. Epidemiology of Allergic and Respiratory Diseases Department, IPLESP, INSERM and Sorbonne University, 75000 Paris, France
2. Institut Desbrest d’Épidémiologie et de Santé Publique, INSERM et Université de Montpellier, 34000 Montpellier, France
Interests: the etiopathogenesis of allergic and respiratory diseases and their comorbidities through an exposomic approach

Special Issue Information

Dear Colleagues,

We are organizing a Special Issue on the Advance in Asthma in the International Journal of Environmental Research and Public Health. The venue is a peer-reviewed, scientific journal that publishes articles and communications in the interdisciplinary area of environmental health sciences and public health. For detailed information about the journal, we refer you to https://www.mdpi.com/journal/ijerph.

Asthma, one of the most common chronic res- piratory disease in adult and children, giving a substantial burden for public health. In the next ten years, there are more than 350 millions people with asthma worldwide. Although the great success of asthma management that has been obtained in the last decades, asthma is still a serious respiratory disease. Currently, asthma is one of diseases that imposes a burden on patients, their families and the community, especially severe asthma. Patients with severe asthma experience a heavy burden of symptoms and exacerbations that requires emergency care and may lead to death in some situations. In addition, patients with severe asthma face to a very high healthcare cost due to biologic treatment, physician visits, and hospitalizations.

Therefore, many objectives in asthma management should be achieved in the near future for well control this disease. More awareness in asthma adherence and asthma treatment in children and adult must be emphasized in the patients' education programs. Advanced biomarkers of Th2- and non-Th2 asthma should be developed by scientists for driving the indication and follow-up of target treatment with biologic therapies in these patients. Finally, more researchs on asthma endotype and phenotype and its modifiable cofactors should be reconsidered by physicians in the next decade.

Hence, this Special Issue of Advance in Asthma opens a new horizon in publication of relevant data and ideas on asthma research in 2020. The listed keywords suggest just a few of the many possibilities.

Prof. Sy Duong-Quy
Prof. Dr. Timothy J Craig
Prof. Dr. Isabella Annesi-Maesano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

asthma prevalence
asthma endotype and phenotype
genetic factors in asthma
control of asthma
asthma treatment
biomarkers of asthma
severe asthma
biologic therapy in asthma
asthma-COPD overlap
allergic asthma
cost- effectiveness in asthma
asthma and air pollution
in door pollution and asthma
prevention of asthma
education of patients with asthma
asthma and obstructive sleep apnea.

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Published Papers (5 papers)

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Research

13 pages, 354 KiB

Open AccessArticle

Exposures in the Indoor Environment and Prevalence of Allergic Conditions in the United States of America

by Janvier Gasana, Boubakari Ibrahimou, Ahmed N. Albatineh, Mustafa Al-Zoughool and Dina Zein

Int. J. Environ. Res. Public Health 2021, 18(9), 4945; https://doi.org/10.3390/ijerph18094945 - 6 May 2021

Cited by 8 | Viewed by 3332

Abstract

Our study examines the association of the presence of mildew, cockroaches, and pets in homes as well as household dust allergens with the prevalence and/or severity of allergic diseases. No study has concurrently assessed home environment exposures in relation to allergic conditions in the general US population. Data from 5409 participants from the 2005–2006 National Health and Nutrition Examination Survey (NHANES) living in their current homes for ≥one year were analyzed. Multivariate logistic regression analyses between home exposures and allergic diseases prevalence and severity were performed. In adjusted analyses, mildew was associated with higher current asthma, allergies, and allergic rhinitis prevalence; endotoxin, with higher current asthma prevalence; and dust Canis familiaris (Can f) 1, with higher allergic rhinitis prevalence. However, presence of cockroaches and dust Dermatophagoides farinae (Der f) 1 were associated, respectively, with lower current asthma and allergies prevalence. Presence of mildew, dust Der f1, Dermatophagoides pteronyssinus (Der p) 1, Felis domesticus (Fel d) 1, and endotoxin were all associated with asthma and/or wheeze severity. Non-atopic asthma was more frequent with mildew and/or musty smell dust and higher dust Fel d1 concentration, while atopic asthma was more prevalent with higher Can f1 and endotoxin concentrations in dust. This study confirms previous relationships and reports novel associations, generating hypotheses for future research. Full article

(This article belongs to the Special Issue Advances in Asthma)

25 pages, 1196 KiB

Open AccessArticle

Reported Neighborhood Traffic and the Odds of Asthma/Asthma-Like Symptoms: A Cross-Sectional Analysis of a Multi-Racial Cohort of Children

by Sarah Commodore, Pamela L. Ferguson, Brian Neelon, Roger Newman, William Grobman, Alan Tita, John Pearce, Michael S. Bloom, Erik Svendsen, James Roberts, Daniel Skupski, Anthony Sciscione, Kristy Palomares, Rachel Miller, Ronald Wapner, John E. Vena and Kelly J. Hunt

Int. J. Environ. Res. Public Health 2021, 18(1), 243; https://doi.org/10.3390/ijerph18010243 - 31 Dec 2020

Cited by 16 | Viewed by 4277

Abstract

Asthma in children poses a significant clinical and public health burden. We examined the association between reported neighborhood traffic (a proxy for traffic-related air pollution) and asthma among 855 multi-racial children aged 4–8 years old who participated in the Environmental Influences on Child Health Outcomes (ECHO) cohort. We hypothesized that high neighborhood traffic density would be associated with the prevalence of asthma. Asthma/asthma-like symptoms (defined as current and/or past physician diagnosed asthma, past wheezing, or nighttime cough or wheezing in the past 12 months) was assessed by parental report. The relationship between neighborhood traffic and asthma/asthma-like symptoms was assessed using logistic regression. The prevalence of asthma/asthma-like symptoms among study participants was 23%, and 15% had high neighborhood traffic. Children with significant neighborhood traffic had a higher odds of having asthma/asthma-like symptoms than children without neighborhood traffic [adjusted OR = 2.01 (95% CI: 1.12, 3.62)] after controlling for child’s race-ethnicity, age, sex, maternal education, family history of asthma, play equipment in the home environment, public parks, obesity and prescribed asthma medication. Further characterization of neighborhood traffic is needed since many children live near high traffic zones and significant racial/ethnic disparities exist. Full article

(This article belongs to the Special Issue Advances in Asthma)

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12 pages, 1243 KiB

Open AccessArticle

How Frequently Is Asthma Objectively Demonstrated before Starting a Biologic? Quality Assessment of a Group Practice of Allergists and Immunologists

by Iwona Dziewa, Timothy Craig and Taha Al-Shaikhly

Int. J. Environ. Res. Public Health 2020, 17(24), 9482; https://doi.org/10.3390/ijerph17249482 - 18 Dec 2020

Cited by 2 | Viewed by 2459

Abstract

Worldwide, asthma-related healthcare cost remains a major burden. Individuals with severe asthma account for 50% of that cost. Although they are expensive, biologics such as anti-IL5 and anti-IgE agents promise cost-effectiveness when judiciously used to decrease asthma-related hospitalization and the debilitating side effects of systemic corticosteroids. Before considering biologics to treat patients with asthma, current guidelines recommend confirmation of asthma and control of comorbid diseases. Diagnostic confirmation of asthma can be challenging among individuals with severe asthma. In this quality assessment study, we determined the frequency of objective asthma confirmation and addressing of comorbidities prior to starting biologics at a group practice of allergists and immunologists. We surveyed our specialty providers to understand habit(s) leading to the observed results. We identified 40 adult patients who started on biologic modifiers for asthma over the past 5 years. Only 58% of these patients had a proper diagnosis of asthma. Providers underutilized several diagnostic methods that may prove useful in confirming asthma diagnosis in this patient population. The factors contributing to poor asthma control were rarely addressed. A sense of urgency to initiate biologics was the primary reason for the observed results. Further interventions are needed to improve asthma diagnosis and management prior to the initiation of biologic therapeutics. Full article

(This article belongs to the Special Issue Advances in Asthma)

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9 pages, 790 KiB

Open AccessArticle

Effects of Inhaled Corticosteroids and Particle Size on Risk of Obstructive Sleep Apnea: A Large Retrospective Cohort Study

by Maria Paula Henao, Jennifer L. Kraschnewski, Matthew D. Bolton, Faoud Ishmael and Timothy Craig

Int. J. Environ. Res. Public Health 2020, 17(19), 7287; https://doi.org/10.3390/ijerph17197287 - 6 Oct 2020

Cited by 10 | Viewed by 4920

Abstract

Background: Inhaled corticosteroids (ICS) produce local effects on upper airway dilators that could increase the risk of developing obstructive sleep apnea (OSA). Given that the particle size of ICS changes their distribution, the particle size of ICS may impact the risk of developing OSA. Objectives: In this large retrospective study, we explore the relationship of ICS use and OSA in patients with asthma. In addition, we seek to determine if this relationship is affected by the particle size of ICS. Methods: Using electronic health records, we established a cohort of 29,816 asthmatics aged 12 and older with a diagnosis of asthma documented by ICD-9 or ICD-10 codes between January 2011 and August 2016. We performed analyses of variance and multivariate logistic regression analysis to determine the effects ICS on the diagnosis of OSA with sub-analysis by particle size of ICS. Results: Uncontrolled asthmatics showed increased odds of receiving a diagnosis of OSA whether when looking at ACT scores (adjusted odds ratio (aOR) 1.60, 95% CI 1.32–1.94) or PFT results (aOR 1.45, 95% CI 1.19–1.77). Users of ICS also had increased odds of OSA independent of asthma control (aOR 1.58, 95% CI 1.47–1.70). Notably, users of extra-fine particle ICS did not have significantly increased odds of having OSA compared to non-users of ICS (aOR 1.11, 95% CI 0.78–1.58). Conclusions: Use of ICS appears to be an independent risk factor for OSA. Notably, extra-fine particle size ICS do not appear to be associated with an increased risk of OSA. Full article

(This article belongs to the Special Issue Advances in Asthma)

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11 pages, 720 KiB

Open AccessArticle

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

by Teodora-Irina Adam-Bonci, Paraschiva Cherecheș-Panța, Eduard-Alexandru Bonci, Sorin Claudiu Man, Ancuța Cutaș-Benedec, Tudor Drugan, Raluca Maria Pop and Alexandru Irimie

Int. J. Environ. Res. Public Health 2020, 17(18), 6545; https://doi.org/10.3390/ijerph17186545 - 9 Sep 2020

Cited by 6 | Viewed by 2741

Abstract

Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D₃ intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month (p = 0.02). Even under seasonal oral vitamin D₃ supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D₃ status in regard to asthma, especially in symptomatic patients. Full article

(This article belongs to the Special Issue Advances in Asthma)

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