Inflammatory Bowel Disease: From Genetics to Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 236
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammatory Bowel Disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease and ulcerative colitis. These diseases are characterized by a complex interplay of genetic, environmental, microbial, and immune factors, leading to chronic inflammation of the gut. The relationship between genetic predisposition and the development of Inflammatory Bowel Disease (IBD), including its two main forms, Crohn's disease and ulcerative colitis. IBD is characterized by chronic inflammation of the gastrointestinal tract, and its etiology involves a complex interplay between genetic and environmental factors. Recent advancements in genome-wide association studies (GWAS) have identified numerous genetic loci associated with IBD, shedding light on the genetic predisposition to the disease. These studies have enhanced our understanding of the genetic architecture of IBD, revealing insights into the underlying biological pathways that contribute to disease susceptibility and progression. Identifying these genetic factors is crucial for developing targeted therapies and personalized medicine approaches for IBD patients. The latest research on genetic predisposition in IBD emphasizes the role of specific genetic variants and their impact on disease phenotypes. It also explores the potential of integrating genetic data with clinical and environmental information to improve disease prediction, diagnosis, and treatment strategies. By examining the genetic basis of IBD, researchers aim to uncover novel therapeutic targets and biomarkers that can lead to more effective and individualized treatment options for patients. Moreover, the issue addresses the therapeutic implications of these genetic findings, discussing current and emerging treatments for IBD. It highlights the role of biologics, small-molecule inhibitors, and other novel therapeutic strategies in managing the disease. The integration of genetic information with therapeutic approaches holds great promise.
Dr. Dalin Li
Guest Editor
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Keywords
- genetic predisposition
- inflammatory bowel disease
- genome-wide association study Crohn's disease
- ulcerative colitis
- bowel disease
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