The Role of RNAs in Cancers: Recent Advances
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 25 November 2024 | Viewed by 213
Special Issue Editor
Special Issue Information
Dear Colleagues,
RNAs play a fundamental and indispensable role in normal cellular physiology and represent an important evolutionary tool for a wide range of adaptive strategies at the genetic and epigenetic levels, with a huge impact on the pathogenesis of diseases, including carcinogenesis. The recent application of next-generation sequencing has allowed for a more precise insight into cancer transcriptomes and proteomes, revealing classical and novel forms of alterations in protein-coding RNAs (such as mRNAs and tRNAs residues) and thousands of aberrantly expressed non-coding RNAs (ncRNAs) associated with various diseases, including cancer. Since the seminal study of Calin and Croce that linked miRNAs to leukaemia, numerous ncRNA subtypes have been identified, such as miRNAs, circRNAs, siRNAs, piRNAs, ncRNAs, snoRNAs, and lncRNAs, and they have been implicated in virtually all aspects of genetic and epigenetic genome regulation. They are also suggested to be involved in various stages of carcinogenesis by acting as either tumour promoters or tumour suppressors in post-transcriptional gene regulation, cell proliferation, metastasis, angiogenesis, cell stemness and drug response.
This Special Issue of IJMS was conceived by the journal’s Editorial Board as a broad overview designed to provide a year-long review of the roles of coding and non-coding RNAs in tumour pathogenesis with emphasis on practical aspects of RNAs as markers in cancer diagnostics and their emerging role in cancer therapy. In particular, but not exclusively, the expected reviews should shed light on the current state of scientific knowledge in the following areas:
- Alterations in mRNAs transcription and processing in tumours—the roles of tRNAs, rRNAs, etc.
- Cross-talk between coding and non-coding RNAs in cancers;
- From cancer-related transcriptomes to proteomes and their correlations;
- Established roles of ncRNAs in cancer pathogenesis;
- Oncogenic and tumour-suppressing potential of lncRNAs;
- MicroRNAs as tumour promotors and suppressors in various cancers;
- Modifying role of circRNAs, piRNAs, snRNAs, snoRNAs, and siRNAs in human cancers;
- RNAs in diagnostics and cancer therapy.
Prof. Dr. Roman Beňačka
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer cells
- carcinogenesis
- mRNAs
- ncRNAs
- lncRNAs
- miRNAs
- circRNAs
- piRNAs
- RNA-based diagnostics
- RNA-based therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
