Microbiome Connections in Age-Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 62
Special Issue Editor
2. Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
Interests: microbiome; gut microbiome; aging-related diseases; Alzheimer’s disease; obesity; diabetes
Special Issue Information
Dear Colleagues,
The microbiome, which consists of a diverse group of bacteria, viruses, archaea, and other microbes present in different regions of the body—primarily in the gut, oral cavity, and skin—forms a symbiotic relationship with its host, playing a significant role in overall health. The composition and interactions of the microbiome are shaped by an individual’s lifestyle and environmental, genetic, and sociodemographic factors throughout life, highlighting its dynamic nature. While aging is a universal process, its impact on physical and intellectual functions varies widely and is influenced by these factors. The microbiome emerges as a crucial element in the progression of age-related health decline and the development of various non-communicable diseases during aging. Chronic low-grade inflammation, often associated with aging and age-related diseases, is frequently triggered by dysregulation of the microflora. This microbiome dysregulation, especially within the gut microbiome, exposes the host to metabolites that influence the inflammatory system, leading to harmful crosstalk between the gut barrier, oral mucosal barrier, and the immune system. This interaction contributes to chronic low-grade inflammation and overall health deterioration. The intricate connection between microbiome dysbiosis and age-related diseases lies in the communication between the microbiome, mucosal barriers, and the systemic immune system, which are closely interconnected.
In this Special Issue, we invite studies that explore the microbiome’s connections with various age-related diseases, including cardiovascular disease, inflammatory bowel disease, obesity, diabetes, musculoskeletal disorders, Alzheimer’s, and dementia. Additionally, we seek to address the potential of restoring microorganisms through lifestyle and dietary interventions to enhance life expectancy and promote healthy aging. This collection of studies aims to uncover the mechanisms by which the microbiome influences aging and to identify strategies to improve health outcomes in older populations.
Dr. Shalini Jain
Guest Editor
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Keywords
- microbiome
- aging
- age-related diseases
- Alzheimer’s
- dementia
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