The Immunometabolic Cross-Talk in Complications of Metabolic Syndrome and Diabetes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 82
Special Issue Editor
Interests: metabolic syndrome; diabetes, diabetic complications; inflammation; innate immunity; fatty acid receptors; toll-like receptors; periodontitis; nonalcoholic fatty liver disease; sphingolipids
Special Issue Information
Dear Colleagues,
The cross-talk or bidirectional interaction between immunological and metabolic factors occurs at molecular, cellular, and tissue levels, playing a key role in the pathogenesis of the complications of obesity, metabolic syndrome, and diabetes. It is well known that the comorbidity of metabolic disorders such as obesity, metabolic syndrome, or type 2 diabetes increases the prevalence and severity of many diseases such as cardiovascular disease, nonalcoholic fatty liver disease, periodontitis, and Alzheimer’s disease. These diseases are thus considered as complications of obesity, metabolic syndrome, and type 2 diabetes. It is also known that, on the one hand, the dysregulated glucose and lipids are capable of activating immune cells, in particular macrophages and T cells, by amplifying proinflammatory signaling, upregulating gene expression, and increasing the production of proinflammatory molecules. On the other hand, the increased proinflammatory molecules such as cytokines are capable of further altering glucose and lipid metabolism. Therefore, the cross-talk between immunological and metabolic factors play a crucial role in tissue destruction, cell proliferation or apoptosis, and functional disruption, promoting the progression of different complications of obesity, metabolic syndrome, and diabetes. The purpose of this Special Issue is to report the recent research progress in the studies of the interaction between immunology and metabolism in the complications of obesity, metabolic syndrome, and diabetes. This Special Issue welcomes original research and review articles in the field with a focus on, but not limited to, the cross-talk between metabolic and immunological factors at the molecular, cellular, or tissue levels which contribute to the initiation and progression of the complications of obesity, metabolic syndrome, and diabetes.
Prof. Dr. Yan Huang
Guest Editor
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Keywords
- metabolism
- immunology
- diabetes
- metabolic syndrome
- obesity
- complications
- inflammatory response
- immune cells
- lipids
- glucose
- sphingolipids
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