Lipid Droplet–Mitochondria Interactions in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 29 November 2024 | Viewed by 290
Special Issue Editor
Interests: mitochondria; lipid droplets; mitophagy; lysosomes; metabolism; obesity; diabetes; neurodegeneration; lysosomal storage disorders; super resolution microscopy; drug discovery
Special Issue Information
Dear Colleagues,
Interorganelle interactions profoundly impact organelle function and signaling. Mitochondria, as key regulators of cellular metabolism, interact and communicate with various intracellular organelles such as the endoplasmic reticulum, nucleus, peroxisomes, and lipid droplets. Our recent discovery that mitochondria bound to lipid droplets, known as peridroplet mitochondria (PDM), in brown adipose tissue exhibit distinct proteomic, metabolic, and dynamic profiles have spurred further research into these interactions across diverse metabolically active tissues, including white adipose tissue, the liver, and skeletal muscle. Additionally, PDM has been found to play significant roles in the development of various pathologies, such as viral infections, fatty liver disease, and cancer. This Special Issue aims to elucidate the unique biology of lipid droplet–mitochondria interactions in various tissues and under different pathological conditions, further exploring their contributions to disease progression and potential therapeutic applications of targeting PDM for treatment and prevention.
Dr. Anton Petcherski
Guest Editor
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Keywords
- mitochondria
- lipid droplets
- metabolism
- lipotoxicity
- metabolically active tissue
- triacylglycerides
- fatty acid oxidation
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