Sepsis and Septic Shock: From Molecular Mechanisms to Novel Therapies—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 198
Special Issue Editors
Interests: sepsis; septic shock; severe infection; hemodynamic management; inflammation; immunology
Special Issues, Collections and Topics in MDPI journals
Interests: sepsis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous successful Special Issue, entitled “Sepsis and Septic Shock: From Molecular Mechanisms to Novel Therapies” (https://www.mdpi.com/journal/ijms/special_issues/HLL3WUGHWD).
Today, knowledge about the prevention and early detection of sepsis and septic shock is still lacking.
In sepsis and septic shock research, there is ongoing controversy regarding the number and importance of activated or repressed pathways and which are relevant in the progression from health to death.
In addition to the classic inflammatory mechanisms, the focus is now also increasingly placed on, e.g., metabolic changes (such as the formation of reactive metabolites), new biomarkers, and epigenetics (including DNA methylation, histone modifications, and non-coding RNAs).
However, of the more than one hundred proposed therapy concepts for sepsis and septic shock, only a few have been adequately investigated and have found their way into everyday clinical practice.
Due to the heterogeneity of septic patients, it could be very helpful to move from the classic therapeutic approaches such as antibiotics, volume therapy, or catecholamine administration to individual therapies tailored to the patient. A deeper understanding of the molecular mechanisms will be the basis for these new treatment options.
Therefore, for this Special Issue, we invite researchers and clinicians to present their original research manuscripts and review articles providing insights into new therapy concepts to prevent or treat the progression of sepsis and septic shock based on new molecular findings.
Prof. Dr. Markus A. Weigand
Prof. Dr. Michael Adamzik
Guest Editors
Manuscript Submission Information
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Keywords
- sepsis
- septic shock
- mechanistic insight
- epigenetics
- immunometabolism
- biomarkers
- therapy approach
- stratification
- precision diagnostics
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