New Insights into Molecular Mechanisms of Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 68
Special Issue Editor
Interests: medical genetics; congenital anomalies; chronic kidney disease; nephrogenetics and kidney genomics; cardiogenetics; neurogenetics; vascular congenital anomalies; reproduction genetic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is increasing in prevalence worldwide and represents a major cause of morbidity and mortality. The pathogenesis of CKD is multifactorial, including complex mechanisms involving numerous genetic factors and molecules involved in inflammation, fibrosis, oxidative stress, endothelial dysfunction, hypoxia, or tubular and podocyte injury. Recent advances in proteomic and molecular technology have identified numerous signaling pathways involved in CKD, including the hyperactivity of the renin-angiotensin (RAS)-aldosterone system, osmotic sodium retention, endothelial dysfunction, dyslipidemia, the RAS/RAF/extracellular-signal-regulated kinase pathway, alterations in the purinergic system, phosphatidylinositol 3-kinase (PI 3-kinase)-dependent signaling pathways, and inflammation, all leading to morphological changes at the vascular and renal levels. Deciphering the molecular mechanisms will allow the development of targeted therapies.
In this Special Issue, we welcome original contributions and scientific reviews on the cellular and molecular aspects of CKD and its complications. We hope the papers published in our journal will significantly contribute to CKD patients.
Dr. Lǎcrǎmioara Ionela Butnariu
Guest Editor
Manuscript Submission Information
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Keywords
- chronic kidney disease
- molecular mechanism
- signaling pathways
- endothelial dysfunction
- inflammation
- genetic variants
- epigenetics
- oxidative stress
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