Mechanistic Studies of Mitosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 403
Special Issue Editor
Special Issue Information
Dear Colleagues,
During mitotic cell division, replicated chromosomes are segregated faithfully into two daughter cells. There are monitoring mechanisms called checkpoints which act during mitosis to ensure proper chromosome attachment and correct chromosome segregation. One checkpoint that functions during early mitosis is called the spindle checkpoint and delays anaphase onset until all chromosomes are properly attached to spindle microtubules emanating from opposite spindle poles. The recruitment of spindle checkpoint proteins to unattached kinetochores is very important for the activation of the spindle checkpoint. Malfunction of the spindle checkpoint can lead to aneuploidy and cancer.
After chromosomes are segregated normally during anaphase, cytokinesis follows. The final step of cytokinesis, in which the narrow cytoplasmic canal that connects the daughter cells is cut, is called abscission. The abscission checkpoint monitors the faithful segregation of DNA and makes sure that there is no trapped chromatin inside the cytoplasmic canal. The abscission checkpoint delays abscission in the presence of chromatin bridges to prevent chromatin breakage or furrow regression and tetraploidization. In mammalian cells, the abscission checkpoint is dependent on the Aurora B kinase and is a matter of active investigation.
In this Special Issue called “Mechanistic Studies of Mitosis”, we focus on the latest research developments in mitosis and mitotic checkpoints.
Dr. Eleni Petsalaki
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitosis
- cancer
- cell biology
- spindle checkpoint
- abscission
- abscission checkpoint
- cytokinesis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
