Advances in Bioactive Peptides: Mechanisms of Action and Biosynthesis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 96
Special Issue Editors
Interests: bioactive compounds; biological activity; functional foods; antimicrobials; cosmeceuticals; nutraceuticals; cellular models; proteomics
Special Issues, Collections and Topics in MDPI journals
Interests: byproducts valorization; bioactive ingredients; antimicrobials; nutraceuticals; microbiota modulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bioactive Peptides (BAPs) represent a diverse class of natural/synthetic molecules that are fundamental to the innate immune response across diverse organisms. Renowned for their swift and versatile activity targeting bacteria, fungi, and viruses, and even influencing cancer cell behavior, BAPs are increasingly recognized as promising alternatives to traditional therapeutic approaches. Their capacity to selectively engage with disease-causing agents without fostering widespread resistance renders them an appealing tool in the ongoing fight against antibiotic-resistant infections, which have ascended to become a prominent global health issue.This Special Issue is dedicated to exploring the complex and multifaceted roles of BAPs, focusing on both their mechanisms of action and the biosynthetic pathways involved in their production. AMPs often act by disrupting microbial cell membranes, but recent research has revealed that they can also modulate immune responses, interfere with biofilm formation, and even target intracellular components of pathogens. Antioxidant peptides have the function of scavenging free radicals in the body and protecting against UV-induced mitochondrial damage and free radical-induced lipid peroxidation. Understanding these diverse modes of action not only provides insights into their therapeutic potential but also opens up new avenues for designing synthetic peptides with enhanced efficacy and specificity.Of equal importance is the study of BAPs biosynthesis, which encompasses a wide range of natural and engineered processes. Advances in genetic engineering and synthetic biology have enabled the development of novel BAPs with optimized properties, paving the way for innovative applications in medicine, agriculture, and biotechnology. This Special Issue will feature research articles and reviews that delve into the latest discoveries in BAPs biosynthesis, including the role of gene regulation, post-translational modification, and microbial production systems.
Dr. Eduardo Costa
Dr. Sara Silva
Guest Editors
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Keywords
- mechanisms of action
- biosynthesis
- bioactive peptides (BAPs)
- innate immunity
- synthetic peptides
- therapeutic applications
- antimicrobial peptides (AMPs)
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