Generation and Expansion of Human Hematopoietic Stem Cells Ex Vivo
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (26 May 2024)
Special Issue Editor
Interests: stem cell biology;regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Hematopoietic cells play a crucial role in cell therapy due to their versatility and importance in various therapeutic applications, such as hematopoietic stem cell transplantation to restore healthy cell production in leukemia and lymphoma patients, and immunotherapy, where they help target and destroy cancer cells. They also play a role in platelet-rich plasma therapy to accelerate wound healing and tissue repair in several medical fields. The development of synthetic red hematopoietic cell substitutes is being explored to address transfusion shortages and infection risks. Ergo, ex vivo cultivation for obtaining a substantial quantity of HSCs emerges as a significant objective in hematological research, marking one of the challenging junctures in this field. However, the sources of hematopoietic cells used in therapy have several limitations, including challenges in finding compatible donors, the risk of immunogenic reactions, limited applicability to hematopoietic-related diseases, concerns about infection and contamination, short shelf-life, and ethical and regulatory issues. In the quest for safer and more effective therapies, it is necessary to explore alternatives, such as pluripotent stem cells, to overcome some of these limitations and provide patient-specific hematopoietic cells for therapeutic use. In addition, the enrichment and expansion of hematopoietic cell generation with advanced technologies such as gene visualization tracking, gene editing and bioreactors is required to realize the broad applications in regenerative medicine and disease treatment. This Special Issue aims to collect original research and review articles focusing on novel technologies or strategies in ex vivo hematopoietic stem/progenitor cell generation, expansion, visualization, dynamic tracking and capturing, gene editing or correction, and scale-up culture for industry and medical translation. We hope that this Special Issue will facilitate the development of hematopoietic cell therapy for more practical and widespread applications. Potential topics include, but are not limited to:
- Advanced technologies and strategies for hematopoietic cell generation and expansion;
- Fate tracking and developmental transition of pluripotent stem cells into hematopoietic stem cells;
- Dissection of molecular maps of hematopoietic cells at the single-cell level;
- Advances in gene editing to modify hematopoietic cells for gene therapy and precision medicine;
- Innovative immunotherapies to enhance the ability of the immune system to target and destroy cancer cells;
- Hematopoietic cell substitutes to address transfusion shortages, reduce the risk of infection and improve the storage and availability of hematopoietic products;
- Techniques for storing and preserving hematopoietic cells to enable their availability for future treatments;
- Niche, circadian rhythm and metabolism for hematopoietic cell reprogramming and differentiation;
- Function and application of hematopoietic derived immune cells in tissue injury and disease repairing.
Dr. Yunwen Zheng
Guest Editor
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Keywords
- generation
- expansion
- human hematopoietic stem cells
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