Pathophysiology of the Serotonin System in the Nervous System and Beyond—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 388
Special Issue Editor
2. Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK
Interests: serotonin; GABA; dopamine; epilepsy; addiction; mood disorders; electrophysiology; habenula; basal ganglia; serotonin2 receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the 1940s, Vittorio Erspamer discovered that an extract, which he prepared from enterochromaffin cells and named enteramine, caused contraction of the intestinal tissue. Ten years later, serotonin (5-hydroxytryptamine, 5-HT) was discovered in the mammalian central and peripheral nervous systems, and successively, its role as an essential neurotransmitter was revealed. Contextually, it was shown that enteramine was the same substance as serotonin. Strikingly, 5-HT is mostly found outside the nervous system, and virtually all 14 serotonin receptors are expressed outside as well as inside the brain.
Serotonin is a neuromodulator present in most organs of numerous species, and plays a role in multiple biological functions. It is also involved in numerous diseases related to peripheral organ dysfunction (e.g., gastrointestinal disorders, cardiac arrhythmia, and hypertension) and central nervous system dysfunction (e.g., obsessive compulsive disorders, addiction, depression, anxiety, schizophrenia, and neurodegenerative diseases). Serotonergic defects are often difficult to uncover in a given disease because they could originate from synthesis/catabolism dysfunction, alteration of the activity of serotonergic cells, changes in reuptake capabilities, and/or transmission. It is acknowledged that serotonin can exert its effects through a plethora of serotonin receptors, and that these receptors can be altered in most diseases. Additionally, an imbalance of serotonin transmission is associated with the dysfunction of other systems, including hormones, neurotrophins, inflammatory systems, and other neurotransmitter systems. The successful identification of the pathomechanisms associated with serotonin system dysfunctions at molecular/cellular levels is expected to enhance the existing serotonin-based medications for numerous diseases.
Continuing the success of our first edition (https://www.mdpi.com/journal/ijms/special_issues/Serotonin), we invite authors to contribute to this Special Issue of IJMS, “Pathophysiology of the Serotonin System in the Nervous System and Beyond 2.0” which aims to collate original articles and reviews, particularly research at the molecular level, from different fields of study pertaining to the advancements in the exploration of the serotonin system’s role in the nervous and other systems. Please note that clinical research and survey studies are not suitable for this Special Issue.
Prof. Dr. Giuseppe Di Giovanni
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pathophysiology
- serotonin receptor
- serotonin metabolism
- pharmacology
- molecular pathway
- system interaction
- omics
- treatments
- neurodegeneration
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
