Glioblastoma: From Molecular Mechanisms to Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 152
Special Issue Editor
Special Issue Information
Dear Colleagues,
Glioblastoma multiforme (GBM) is a lethal malignant adult brain cancer, known to recur following conventional therapy (surgical resection, chemotherapy, radiotherapy). While GBM is classified based on the transcriptional status of cells, recent studies using single cell and spatial omics have identified inter- and intra-tumoral heterogeneity in GBM, suggesting a need for novel and personalized treatment options. The “cold” immunosuppressive microenvironment, coupled with the tight surveillance of the blood–brain barrier in GBM results in dismal outcomes of immunotherapy clinically. Cellular communication between glioma cells and its microenvironment (including immune cells, endothelial cells, pericytes, astrocytes, neurons, and others) occur via the exchange of signals in a contact-dependent or -independent fashion, triggering therapeutic resistance and other alterations in the recipient cell. The former uses contact-dependent signaling pathways or the formation of nanotubes, while the latter employs the uptake of soluble factors or molecules encased in nanosized particles called extracellular vesicles (EVs) from donor cells. EVs are also being investigated to identify unique biomarkers in a liquid biopsy platform in order to determine the GBM subtype and evolution post treatment. Therefore, intercellular communication in conjunction with recent implications due to microenvironmental reorganization stimulates explorations of novel therapeutic strategies beyond conventional treatments.
This Special Issue, entitled “Glioblastoma: From Molecular Mechanisms to Therapies”, invites contributions, including original research articles, reviews, multi-omic analysis, or short perspective articles, on all aspects relating to the complex molecular pathophysiology of GBM, including diagnostic and prognostic biomarkers and novel therapeutic approaches to treat GBM.
Dr. Lata Adnani
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glioblastoma
- heterogeneity
- tumor microenvironment
- therapy resistance
- immunotherapy
- extracellular vesicles
- biomarkers
- vascular endothelial cells
- pericytes
- blood–brain barrier
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
