Dietary Bioactive Compounds and Their Impact in Epigenetic Chemoprevention
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 336
Special Issue Editors
Interests: cancer cell biology; cancer biomarkers; anti-cancer therapy; cancer epigenetics; DNA methylation; nutritional epigenomics
Special Issues, Collections and Topics in MDPI journals
Interests: cancer cell biology; cancer biomarkers; anti-cancer therapy; cancer epigenetics; DNA methylation; nutritional epigenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancerous diseases are a leading cause of death worldwide. Therefore, it is pivotal to search for dietary bioactive compounds that can avert tumor development. A diet rich in vegetables and fruits provides chemopreventive substances, which have the potential to prevent many diseases, including cancer. Numerous phytochemicals, including polyphenols, phytoestrogens, and plant-derived peptides possess anti-cancer activity and have been studied for several decades. The results of the latest research have shown that many natural compounds are potent epigenetic modulators and thus seem to be promising bioactive chemopreventive agents. They can reverse cancer-specific dysregulated epigenetic code, i.e., aberrant DNA methylation patterns, and lead to the activation of methylation-silenced tumor suppressor genes and concomitant suppression of demethylation-activated oncogenes and prometastatic genes. As the epigenetic mechanisms regulated by natural compounds, including DNA methylation, histone modifications, non-coding RNA mechanisms, and RNA methylation, are concerted in the epigenetic network that determines the transcriptional activity of certain genes, the bioactive phytochemicals may be involved in sensitizing cancer cells to conventional anti-cancer therapeutics.
This Special Issue plans to give an overview of the most recent advances in epigenetic chemoprevention and therapy with the application of natural bioactive compounds as a potential source of epigenetic biomarkers for dietary exposures and anti-cancer therapies based on plant bioactive components.
Potential topics include, but are not limited to:
- Dietary bioactive compounds targeting epigenetic pathways in cancer;
- Epigenetic chemoprevention;
- Epigenetic anti-cancer therapy;
- Epigenetic biomarkers for dietary exposures.
Dr. Katarzyna Lubecka-Gajewska
Dr. Agnieszka Kaufman-Szymczyk
Guest Editors
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