Mutant p53 in Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 377
Special Issue Editor
Special Issue Information
Dear Colleagues,
The importance of cancer-cell-autonomous functions of the tumor suppressor p53 (encoded by TP53) has been established in many studies. Loss or mutation of p53 in cancers can affect fundamental cellular pathways and cancer progression. Understanding the genetic and epigenetic mechanisms that control the p53 protein, as well as its complex post-translational regulation will help to design more effective therapies to target mutated p53 in cancer.
This special issue will focus on original studies describing the unraveled roles of mutant p53 in cancers. Research topics may include (but are not limited to) the following:
- Restoring p53 activity in cancer;
- p53-dependent and p53-independent strategies for targeting p53 pathway functional restoration in p53-mutated cancer
- Targeting p53 mutations and/or p53 pathway;
- Combination therapies targeting p53, immune checkpoints for cancer therapy
- Role of TP53 mutations in cancer;
- Correlation of TP53 mutations with other gene mutations in cancer.
Dr. Musaffe Tuna
Guest Editor
Manuscript Submission Information
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Keywords
- mutant p53
- cancer
- tumor heterogeneity
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