Non-Coding RNA in Physiology and Pathophysiology: Second Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 102
Special Issue Editor
Special Issue Information
Dear Colleagues,
Non-coding RNAs (ncRNAs) are a class of non-protein-coding transcripts widely expressed in mammalian cells with a tissue- and cell-specific distribution pattern. High-throughput RNA-sequencing technology has revealed the key role played by ncRNAs as developmental and evolutionary determinants of organismal complexity. NcRNA mainly includes microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). Among small ncRNAs, miRNAs are capable of post-transcriptionally regulating many targets, thus fine-tuning a wide range of cellular pathways. Long ncRNAs can, in turn, regulate miRNAs’ expression and control gene transcription, pre-mRNA processing, the transport of mature mRNAs to specific cellular compartments, the regulation of mRNA stability, and protein translation and turnover. CircRNAs are single-stranded, covalently closed RNA molecules that exert biological functions by acting as transcriptional regulators, miRNA sponges, and protein templates.In recent decades, the dysregulation of ncRNAs has been implicated in a wide variety of pathological conditions, including pain, senescence and degenerative disease such as cardiometabolic disease, cancer, and neurodegenerative disorders. The functions of ncRNAs in pathogenesis are unique for each disorder, as are the pertinent networks of ncRNA/miRNA/mRNA that mediate these functions. Thus, further understanding ncRNA biogenesis, release, and effects may aid the discovery of diagnostic biomarkers or the development of effective therapeutics for degenerative and age-related diseases affecting modern society.
The aim of this Special Issue is to collect novel findings on molecular mechanisms related to ncRNA function in physiological and pathological conditions. Bioinformatics studies that explore how data analysis and computational technologies can reveal new targets for the implementation of innovative therapeutic strategies are also encouraged. Original research articles, up-to-date reviews, and commentaries are all welcome.
Dr. Maria Rosaria Tumolo
Guest Editor
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Keywords
- microRNA
- long non-coding RNA
- circular RNA
- epigenetics
- musculoskeletal pain
- cardiovascular disease
- metabolic disease
- nervous system disorders
- cancer
- aging
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