Red Blood Cells in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 25 June 2025 | Viewed by 95
Special Issue Editors
Interests: chloroquine; red blood cells; antioxidant systems; band-3 protein; sulphate transport; hemoglobin; oxygenation-deoxygenation cycle
Interests: antioxidant activity; antioxidants; oxidative stress; red blood cells; oxygen; resveratrol; flavonoids; lipid peroxidation; hemoglobin; erythrocyte membranes; blood; free radicals; free radical scavengers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Red blood cells (RBCs) are the functional components of blood, which play a key role in oxygen and nutrient supply to the human body and the concomitant excretion of carbonic dioxide (CO2). They are also the principal determinant of viscosity and dynamics of the bloodstream. The multiple functionalities of RBCs allow them to be very sensitive to their surroundings reflecting the organism’s pathophysiological status; RBCs respond to environmental changes with several adaptations including changing shape, altered in size, rigidity, and distribution width, regulating systemic metabolism and vasodilation, activating the immune system. In this context, peculiar disease-related alterations of RBCs have been observed, such as in diabetes, cancer, and neurodegenerative disorders, and these cells could be used as potential biomarkers of disease. Their peculiar properties mean that they could also be used as potential drug targets or even offer an alternative chance for drug delivery. It has been demonstrated that even the viral infections that have characterized in recent years cause significant damage to the blood cells and patients with severe COVID-19 showed an increase in hematological changes, indicating a progressive worsening as COVID-19 severity progressed. Therefore, monitoring hematological alterations in patients may play an important role in the management of the diseases and prevent the risk of a severe course of the disease.
Dr. Annamaria Russo
Prof. Dr. Ester Tellone
Guest Editors
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Keywords
- oxidative stress
- metabolism
- hemoglobin
- erythrocytes
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