Oxidative Stress and Mitochondria in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 398
Special Issue Editor
2. Escuela de Medicina, Campus San Felipe, Universidad de Valparaíso, La Troya Esquina El Convento s/n, San Felipe, Chile
Interests: insulin resistance; obesity; n3-PUFA; lipoperoxidation; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondrial dysfunction, associated with a higher production of reactive oxygen species, is implicated in various human conditions, such as cardiovascular diseases, metabolic syndromes, neurodegenerative diseases, and skeletal muscle diseases. The imbalance between fusion and fission processes helps maintain mitochondrial function by mixing the contents of partially damaged mitochondria, whereas fission is essential for removing damaged mitochondria through mitophagy. On the other hand, alterations in the interaction between mitochondrial and lipid droplets have metabolic implications, considering that the disruption of this interaction can lead to lipid accumulation inside the cell and lipotoxicity, triggering ferroptosis, an iron-dependent cellular death. Dysregulated autophagy with the worsening of mitochondria dysfunction has also been implicated in many diseases. Inadequate autophagy leads to the accumulation of damaged mitochondria, increasing ROS production and cellular stress. In neurodegenerative diseases, impaired autophagy contributes to the build up of toxic protein aggregates and dysfunctional organelles, accelerating neuronal death. Novel molecular mechanisms involved in mitochondrial dysfunction associated with the overproduction of oxidant species from this disequilibrium and their implication in the pathophysiology of chronic diseases must be analyzed.
This Special Issue aims to gather cutting-edge research and comprehensive reviews addressing related topics, such as mitochondrial dysfunction and oxidative stress biomarkers, interventions to recover mitochondrial dynamics, and molecular mechanisms associated with mitochondrial biogenesis.
We look forward to your valuable contributions to this exciting Special Issue.
Dr. Alejandra Espinosa
Guest Editor
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Keywords
- mitochondrial dynamics
- ROS
- antioxidants
- mitophagy
- oxidative damage
- lipid peroxidation
- neurodegenerative diseases
- cancer
- obesity
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